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102 条记录 (耗时 0.023 秒)

    Method and apparatus for automatic tissue staining
    91.
    发明授权
    Method and apparatus for automatic tissue staining 有权
    自动组织染色的方法和装置

    公开(公告)号：US06735531B2

    公开(公告)日：2004-05-11

    申请号：US10010830

    申请日：2001-11-13

    申请人： Norman K. Rhett ,  Ken K. Tseung ,  Mark V. Corl ,  Wai Bun Wong ,  Ngoc Van Le ,  Glenn K. Takayama

    发明人： Norman K. Rhett ,  Ken K. Tseung ,  Mark V. Corl ,  Wai Bun Wong ,  Ngoc Van Le ,  Glenn K. Takayama

    IPC分类号： G01N3353

    CPC分类号： G01N35/00584 ,  G01N1/312 ,  G01N35/00663 ,  G01N2001/317 ,  G01N2035/0091

    摘要： To simplify the process of preparing microscope slides, an automatic staining apparatus is disclosed. The disclosed automatic staining apparatus comprises an electromechanical automatic staining device that is coupled to a personal computer system using an interface card. An autostainer control program runs on the personal computer system. The autostainer control program allows a user to simply program the automatic staining apparatus using simple commands entered in the graphical user interface. The autostainer control program includes several features that simplify the programming such as safeguards that ensure compatible reagents are being used; automatic buffer solution requirement calculator; and the ability to determine optimal staining procedure. The electromechanical automatic staining device includes features such as dual waste bins for hazardous and nonhazardous waste storage, an automatic dispenser cleansing system; and a slide clip that minimizes capillary effect.

    摘要翻译： 为了简化制备显微镜载片的过程，公开了一种自动染色装置。 所公开的自动染色装置包括使用接口卡耦合到个人计算机系统的机电自动染色装置。 一个自动调色器控制程序在个人计算机系统上运行。 自动涂布器控制程序允许用户使用在图形用户界面中输入的简单命令简单地编程自动染色装置。 自动清洗器控制程序包括几个简化编程的功能，例如确保使用兼容试剂的保护措施; 自动缓冲溶液需求计算器; 以及确定最佳染色程序的能力。 机电自动染色装置包括用于危险和非危险废物储存的双垃圾箱，自动分配器清洁系统等功能; 以及使毛细管效应最小化的滑动夹。

    Apparatus comprising a reagent atomization and delivery system
    92.
    发明申请
    Apparatus comprising a reagent atomization and delivery system 审中-公开
    装置包括试剂雾化和递送系统

    公开(公告)号：US20020179848A1

    公开(公告)日：2002-12-05

    申请号：US09872415

    申请日：2001-06-02

    发明人： Ilya Feygin

    IPC分类号： G01J001/00

    CPC分类号： G01N21/6452 ,  B01J2219/00427 ,  B01L3/0268 ,  B01L2300/0829 ,  B01L2400/0415 ,  B01L2400/0439 ,  B22F2998/00 ,  B22F2999/00 ,  C40B60/14 ,  G01N21/11 ,  G01N21/253 ,  G01N25/72 ,  G01N2001/317 ,  G01N2021/6482 ,  G01N2035/1034 ,  B22F3/115 ,  B22F9/08 ,  B22F2202/01

    摘要： An apparatus comprising a reagent atomization and delivery system. In one embodiment, a reagent atomization and delivery system includes an atomizer that uniformly and simultaneously delivers a spray of atomized reagent toward a plurality of reagent receiving sites on a specimen plate. The reagent atomization and delivery system is advantageously used in conjunction with an imaging system (e.g., visible-spectrum, infrared-spectrum, etc.). Specifically, once the atomized reagent is dispensed, it triggers chemical/physiological reactions that are then advantageously subjected to imaging analysis (e.g., visible-spectrum imaging, infrared spectrum imaging, etc.).

    摘要翻译： 一种包括试剂雾化和递送系统的装置。 在一个实施方案中，试剂雾化和递送系统包括雾化器，其均匀地并且同时地将雾化试剂的喷雾朝向样品板上的多个试剂接收部位传送。 试剂雾化和递送系统有利地与成像系统（例如可见光谱，红外光谱等）结合使用。 具体地说，一旦分配了雾化试剂，就会触发化学/生理反应，然后有利地进行成像分析（例如可见光谱成像，红外光谱成像等）。

    Testing system for chemical substances or substance mixtures
    94.
    发明申请
    Testing system for chemical substances or substance mixtures 审中-公开
    化学物质或物质混合物的测试系统

    公开(公告)号：US20020110920A1

    公开(公告)日：2002-08-15

    申请号：US09881072

    申请日：2002-04-11

    发明人： Jorg Mentzen ,  Helmut Kessmann ,  Harald Danigel ,  Gerhard Klokow ,  Peter Obergfell

    IPC分类号： G01N035/00

    CPC分类号： G01N35/00 ,  B01J2219/00585 ,  B01J2219/00707 ,  G01N2001/317 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/163333 ,  Y10T436/25 ,  Y10T436/2575

    摘要： In a testing system for chemical substances or substance mixtures, especially for potential plant protection compositions, the chemical substance to be tested or the substance mixture to be tested is applied to a test specimen, especially to plants or parts of plants. When a predetermined period of time has elapsed, the test specimen is examined for the activity of the substance or substance mixture. For this purpose, first of all a type of test specimen is selected from a stock of test specimens, and the substances to be tested are selected from a stock of substances to be tested. The selected type of test specimen and the selected substances are identified (BC1, BC2) by means of a machine-readable code and those codes are supplied to a memory unit (12). The test specimens are placed in readiness in a carrier plate (30), for which purpose each test specimen or a section (BR) of test specimen is deposited in a well (300) that is provided in the carrier plate (30) and that is partly filled with a nutrient solution (301). Then a spraying device (150, 151) is inserted into the well (300) of the carrier plate (30) and sprays the test specimen deposited therein with the selected substance and is then removed from the well (300) again or the spraying device is positioned immediately above the well (300) of the carrier plate (30) and sprays the test specimen deposited therein with the selected substance.

    摘要翻译： 在用于化学物质或物质混合物的测试系统中，特别是对于潜在的植物保护组合物，要测试的化学物质或待测试的物质混合物应用于试样，特别是植物或植物部分。 当经过预定的时间段时，检查试样的物质或物质混合物的活性。 为此，首先从试样的库存中选出一种试样，待测试的物质选自待测物质的库存。 通过机器可读代码识别选定类型的测试样本和所选择的物质（BC1，BC2），并将这些代码提供给存储器单元（12）。 将测试样品置于载体板（30）中，为此目的，每个试样或试样的部分（BR）沉积在设置在载体板（30）中的孔（300）中，并且 部分地充满营养液（301）。 然后将喷涂装置（150,151）插入承载板（30）的井（300）中，并将沉积在其中的试样喷射到所选择的物质上，然后再次从井（300）中取出或喷射装置 位于承载板（30）的孔（300）的正上方，并且将其中沉积有所选择的物质的试样喷射。

    Fluid dispenser
    95.
    发明授权
    Fluid dispenser 有权
    流体分配器

    公开(公告)号：US06416713B1

    公开(公告)日：2002-07-09

    申请号：US09483218

    申请日：2000-01-14

    申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

    发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

    IPC分类号： C01H3510

    CPC分类号： G01N35/1016 ,  G01N1/312 ,  G01N35/00871 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00881 ,  G01N2035/1034 ,  Y10T137/7873 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

    摘要： A method of assembly of a fluid dispenser of an apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

    摘要翻译： 提供了一种组装用于自动生物反应系统的装置的流体分配器的方法。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

    Testing system for chemical substances or substance mixtures
    98.
    发明授权
    Testing system for chemical substances or substance mixtures 有权
    化学物质或物质混合物的测试系统

    公开(公告)号：US06277642B1

    公开(公告)日：2001-08-21

    申请号：US09117968

    申请日：1999-02-16

    申请人： Jörg Mentzen ,  Helmut Kessmann ,  Harald Danigel ,  Gerhard Klokow ,  Peter Obergfell

    发明人： Jörg Mentzen ,  Helmut Kessmann ,  Harald Danigel ,  Gerhard Klokow ,  Peter Obergfell

    IPC分类号： G01N3500

    CPC分类号： G01N35/00 ,  B01J2219/00585 ,  B01J2219/00707 ,  G01N2001/317 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/163333 ,  Y10T436/25 ,  Y10T436/2575

    摘要： In a testing system for chemical substances or substance mixtures, especially for potential plant protection compositions, the chemical substance to be tested or the substance mixture to be tested is applied to a test specimen, especially to plants or parts of plants. When a predetermined period of time has elapsed, the test specimen is examined for the activity of the substance or substance mixture. For this purpose, first of all a type of test specimen is selected from a stock of test specimens, and the substances to be tested are selected from a stock of substances to be tested. The selected type of test specimen and the selected substances are identified (BC1, BC2) with a machine-readable code and those codes are supplied to a memory unit (12). The test specimens are placed in readiness in a carrier plate (30), for which purpose each test specimen or a section (BR) of test specimen is deposited in a well (300) that is provided in the carrier plate (30) and that is partly filled with a nutrient solution (301). Then a spraying device (150, 151) is inserted into the well (300) of the carrier plate (30) and sprays the test specimen deposited therein with the selected substance and is then removed from the well (300) again or the spraying device is positioned immediately above the well (300) of the carrier plate (30) and sprays the test specimen deposited therein with the selected substance.

    摘要翻译： 在用于化学物质或物质混合物的测试系统中，特别是对于潜在的植物保护组合物，要测试的化学物质或待测试的物质混合物应用于试样，特别是植物或植物部分。 当经过预定的时间段时，检查试样的物质或物质混合物的活性。 为此，首先从试样的库存中选出一种试样，待测试的物质选自待测物质的库存。 使用机器可读代码识别所选择的测试样本和所选物质（BC1，BC2），并将这些代码提供给存储单元（12）。 将测试样品置于载体板（30）中，为此目的，每个试样或试样的部分（BR）沉积在设置在载体板（30）中的孔（300）中，并且 部分地充满营养液（301）。 然后将喷涂装置（150,151）插入承载板（30）的井（300）中，并将沉积在其中的试样喷射到所选择的物质上，然后再次从井（300）中取出或喷射装置 位于承载板（30）的孔（300）的正上方，并且将其中沉积有所选择的物质的试样喷射。

    Container for staining of cells and tissues in combination with a roller and a support
    99.
    发明授权
    Container for staining of cells and tissues in combination with a roller and a support 失效
    用于与滚筒和支架结合的细胞和组织的染色容器

    公开(公告)号：US5843793A

    公开(公告)日：1998-12-01

    申请号：US728586

    申请日：1996-10-10

    申请人： Robert Troconis Belly ,  John Robert Chemelli ,  Michele McWilliams Steinmann

    发明人： Robert Troconis Belly ,  John Robert Chemelli ,  Michele McWilliams Steinmann

    IPC分类号： G01N33/48 ,  B01L3/00 ,  B01L3/02 ,  G01N1/31 ,  G01N35/02 ,  G01N35/10 ,  H01J49/04 ,  G01N33/558 ,  G01N22/00

    CPC分类号： B01L3/505 ,  B01L3/0241 ,  G01N1/31 ,  G01N35/1002 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N2001/317 ,  Y10S435/81

    摘要： A flexible container containing pre-deposited reagents, comprising a plurality of temporarily sealed, breakable compartments dispersed in the container, each compartment containing a reagent useful for immuno-assaying, and each compartment comprising opposed confining walls at least one of which is sufficiently flexible as to allow the compartment to be compressed in the presence of an adequate external force, external outlets in the container for the contents of said compartments, passageways extending from each of the compartments to the outlets, each of the outlets terminating in a platform that supports a drop of at least 10 .mu.L as a pendant drop, the platforms of at least two of the outlets being adjacent so as to form between them an exterior angle with respect to each other sufficient to cause drops pendant therefrom to substantially uniformly intermix.

    摘要翻译： 包含预先沉积的试剂的柔性容器，包括分散在容器中的多个临时密封的可破坏的隔室，每个隔室含有可用于免疫测定的试剂，每个隔室包含相对的限制壁，其中至少一个具有足够的柔韧性 以允许隔室在足够的外力的存在下被压缩，容器中的外部出口用于所述隔室的内容物，从每个隔室延伸到出口的通道，每个出口终止于支撑 至少有两个出口的平台相邻，以便在它们之间形成彼此相互之间的外部角度，足以引起其垂下的液滴基本均匀地混合。