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    Bismuth Hyaluronate, the Preparation Method and the Use Thereof
    92.
    发明申请
    Bismuth Hyaluronate, the Preparation Method and the Use Thereof 有权
    透明质酸铋，其制备方法及其用途

    公开(公告)号：US20080312429A1

    公开(公告)日：2008-12-18

    申请号：US12095797

    申请日：2006-12-01

    申请人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

    发明人： Peixue Ling ,  Yanli He ,  Jianying Chen ,  Jie Liu ,  Tianmin Zhang ,  Xueping Guo ,  Yan Jin

    IPC分类号： C08B37/08 ,  C07H23/00

    CPC分类号： A61K31/728 ,  C08B37/0072

    摘要： The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate comprising reaction of a soluble hyaluronate salt with a bismuth salt in a basic aqueous solution, followed by steps of precipitation, filtration, desalting, dehydrating and drying to obtain the product. Further disclosed is the use of the bismuth hyaluronate in the manufacture of a medicament or health foods for preventing and treating gastrointestinal disorders, in particular ulcerous disorders of the GI tract. It has been proven in animal experiments to show a better therapeutic effect than products of the same type.

    摘要翻译： 本发明公开了一种透明质酸铋，其特征在于，所述铋含量为0.5〜40％，所述葡萄糖醛酸酯含量为20〜45％。 还提供了一种制备所述透明质酸铋的方法，包括在碱性水溶液中使可溶性透明质酸盐与铋盐反应，然后进行沉淀，过滤，脱盐，脱水和干燥以获得产物。 进一步披露的是透明质酸铋在制造用于预防和治疗胃肠道疾病，特别是胃肠道溃疡性疾病的药物或保健食品中的用途。 在动物实验中已经证明比相同类型的产品显示更好的治疗效果。

    Labeling proteins with dyes that are insoluble or only sparingly soluble in water
    93.
    发明授权
    Labeling proteins with dyes that are insoluble or only sparingly soluble in water 有权
    用不溶于或微溶于水的染料标记蛋白质

    公开(公告)号：US07435603B2

    公开(公告)日：2008-10-14

    申请号：US11249683

    申请日：2005-10-12

    申请人： Mingde Zhu ,  Lee Olech

    发明人： Mingde Zhu ,  Lee Olech

    IPC分类号： G01N33/533 ,  C07D309/00 ,  C07H23/00

    CPC分类号： G01N33/54366 ,  G01N33/6839 ,  G01N2021/6439 ,  Y10S435/968 ,  Y10S436/80 ,  Y10T436/13

    摘要： The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the dye, a buffering agent, and in preferred embodiments, a denaturing agent as well. The solid and dry form of the composition prevents the dye from deteriorating or decomposing, and the combination of components in the composition allows the dye to couple to the proteins in a relatively uniform manner with no overstaining of the protein when the composition and the sample are heated together and held at an elevated temperature for a short period of time.

    摘要翻译： 通过电泳或色谱方法试图分析其蛋白质组成的生物样品中的蛋白质通过将样品与含有染料，缓冲剂和固体干燥组合物的固体干燥组合物以非常有效的方式偶联到染料上 在优选的实施方案中，还可以使用变性剂。 组合物的固体和干燥形式可防止染料劣化或分解，组合物中组分的组合允许染料以相对均匀的方式偶联蛋白质，当组合物和样品为 一起加热并在高温下保持短时间。

    APPARATUS AND METHOD FOR ISOLATING IRON COMPONENTS FROM SERUM
    94.
    发明申请
    APPARATUS AND METHOD FOR ISOLATING IRON COMPONENTS FROM SERUM 审中-公开
    从血清中分离铁组分的装置和方法

    公开(公告)号：US20080132465A1

    公开(公告)日：2008-06-05

    申请号：US11567029

    申请日：2006-12-05

    申请人： Vincent Windisch ,  Pui-Ho Yuen ,  Jing Jun Huang ,  Jingzhen Xu

    发明人： Vincent Windisch ,  Pui-Ho Yuen ,  Jing Jun Huang ,  Jingzhen Xu

    IPC分类号： A61K31/7016 ,  C07H23/00 ,  B01D11/00 ,  G01N21/01 ,  G01N33/20

    CPC分类号： B01D15/08 ,  G01N33/66 ,  G01N33/84

    摘要： A method and apparatus for isolating iron components in serum is provided. The method includes passing a serum sample through a separation column having a solid phase and retaining with the solid phase an iron component, such as an iron carbohydrate, in the column. Elution of the solid phase may retrieve an eluate containing the iron component. The amount of iron component present in the eluate may then be measured. The present method and apparatus advantageously permit the direct measurement of the iron component present in the serum.

    摘要翻译： 提供了一种用于分离血清中铁成分的方法和装置。 该方法包括使血清样品通过具有固相的分离柱，并在固相中保留柱中的铁组分如铁碳水化合物。 固相的洗脱可以检索含有铁组分的洗脱液。 然后可以测量存在于洗脱液中的铁成分的量。 本方法和装置有利地允许直接测量血清中存在的铁成分。

    Process for producing methylcobalamin
    96.
    发明授权
    Process for producing methylcobalamin 失效
    生产甲基钴胺素的方法

    公开(公告)号：US07220855B2

    公开(公告)日：2007-05-22

    申请号：US10476381

    申请日：2002-06-04

    申请人： Yoshihiko Hisatake ,  Takuo Tanaka ,  Tomio Tsurugi ,  Hiroshi Kuroda

    发明人： Yoshihiko Hisatake ,  Takuo Tanaka ,  Tomio Tsurugi ,  Hiroshi Kuroda

    IPC分类号： C07H23/00

    CPC分类号： C07H23/00

    摘要： The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cyanocobalamin or hydroxocobalamin in the presence of a reducing agent, and then methylating the reductant by adding a water-soluble methylating agent.

    摘要翻译： 本发明提供了一种生产甲基钴胺素的新型工业上优良和生态的方法，其可用作药物等。更具体地，本发明提供了在还原剂存在下还原氰钴胺素或羟钴胺素，然后使还原剂甲基化制备甲基钴胺素的方法 通过添加水溶性甲基化剂。

    Protecting groups for carbohydrate synthesis
    99.
    发明授权
    Protecting groups for carbohydrate synthesis 有权
    碳水化合物合成保护基

    公开(公告)号：US06953850B1

    公开(公告)日：2005-10-11

    申请号：US09889687

    申请日：2000-01-18

    申请人： Gyula Dekany ,  John Papagerogiou ,  Laurent Francois Bornaghi

    发明人： Gyula Dekany ,  John Papagerogiou ,  Laurent Francois Bornaghi

    IPC分类号： C07H5/06 ,  C07H1/00 ,  C07H15/14 ,  C07H15/26 ,  C07H19/02 ,  C07H19/24 ,  C07H23/00 ,  C07H15/20 ,  C07H15/22 ,  C08F212/08

    CPC分类号： C07H1/00 ,  C07H15/26 ,  Y02P20/55

    摘要： The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N3; X1 is hydrogen, —CH2O—, —CH2NH—, —CH3, —CH2N3 or —COO—; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N3, and E is absent when X1 is hydrogen, CH3 or N3.

    摘要翻译： 本发明提供正交保护的单糖的集合作为用于合成非糖分子，新糖缀合物和寡糖的糖缀合物的通用结构单元。 这种正交保护策略允许对糖环上任何取代基的特异性去保护，并且极大地促进靶向或文库重点的碳水化合物相关合成。 特别地，本发明提供通式（I）或通式（II）的通用单糖结构单元，其中A为离去基团; X是氢，O，N或N 3; X 1是氢，-CH 2 O - ， - CH 2 NH-， - CH 3 - ， - CH 2 N 3 N或-COO-; 并且B，C，D和E是可以正交裂解的保护基，当​​X是氢或N 3时，B，C，D和E不存在，当X不存在时，E不存在 1是氢，CH 3或N 3。