公开(公告)号：US20230241171A1

公开(公告)日：2023-08-03

申请号：US18004801

申请日：2021-07-09

Applicant: INSTITUT PASTEUR ,  MCMASTER UNIVERSITY

Inventor： Lida KATSIMPARDI ,  Pierre-Marie LLEDO ,  Bianca WOLLENHAUPT DE AGUIAR ,  Taiane DE AZEVEDO CARDOSO ,  Flavio KAPCZINSKI ,  Bianca PFAFFENSELLER

IPC: A61K38/18 ,  G01N33/68 ,  A61P25/24 ,  C07K16/22

CPC classification number: A61K38/1841 ,  G01N33/6896 ,  A61P25/24 ,  C07K16/22 ,  G01N2800/304

Abstract: Provided are methods for the detection of GDF11 in a subject having or suspected of having a mood and/or anxiety disorder, comprising providing a sample from a subject having or suspected of having a mood and/or anxiety disorder; contacting the sample with a GDF11-binding molecule; and detecting bound GDF11. Also provided are methods of diagnosing or characterizing a mood and/or anxiety disorder in a subject, comprising providing a sample from a subject; contacting the sample with a GDF11-binding molecule; detecting bound GDF11; and comparing the levels of detected bound GDF11 to healthy reference levels. Also provided are methods of treating or preventing a mood and/or anxiety disorder and/or accelerated aging in a subject in need thereof, comprising administering to the subject an agent or composition which increases the levels of GDF11 polypeptide in the subject.

公开(公告)号：US20230158507A1

公开(公告)日：2023-05-25

申请号：US18097781

申请日：2023-01-17

Applicant: McMaster University

Inventor： Sebastian Himbert ,  Maikel Rheinstadter

IPC: B01L3/00 ,  G01N27/327 ,  G01N33/53 ,  G01N33/49

CPC classification number: B01L3/5085 ,  B01L3/502715 ,  G01N27/3272 ,  G01N33/5306 ,  G01N27/3277 ,  G01N33/49 ,  G01N27/3275

Abstract: Provided herein is a biosensor suitable for use in measuring membrane fluidity or membrane permeability. The biosensor is formed of a solid substrate having a lipid bilayer compatible surface and a multi-lamellar lipid membrane structure localized on the lipid bilayer compatible surface. The multi-lamellar lipid membrane structure can be derived from a biological cell further comprising one or more synthetic lipids. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the lipid membrane structure and hemolytic activity in a test sample.

公开(公告)号：US20230113567A1

公开(公告)日：2023-04-13

申请号：US17964347

申请日：2022-10-12

Applicant: McMaster University

Inventor： Jakob Magolan ,  Nicholas Jentsch ,  Xiong Zhang ,  Mathew Piotrowski ,  Patrick Darveau ,  Meghan Fragis ,  Jarrod Johnson ,  Nicole Ritchie ,  Arnav Kaul

IPC: C07C37/14 ,  C07J7/00 ,  B01J21/04 ,  C07D209/08 ,  C07C41/26 ,  C07D307/80 ,  C07C201/12 ,  C07J1/00 ,  C07D311/30 ,  C07D311/32 ,  C07C253/30

Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

公开(公告)号：US11577248B2

公开(公告)日：2023-02-14

申请号：US16229487

申请日：2018-12-21

Applicant: McMaster University

Inventor： Maikel Rheinstadter ,  Sebastian Himbert ,  Richard Alsop ,  Jose Moran-Mirabal ,  Sokunthearath Saem ,  Dawn Bowdish

IPC: B01L3/00 ,  G01N33/53 ,  G01N27/327 ,  G01N33/49

Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.

公开(公告)号：US11549945B2

公开(公告)日：2023-01-10

申请号：US16875707

申请日：2020-05-15

Applicant: McMaster University

Inventor： John D. Brennan ,  Yingfu Li ,  Monsur Ali ,  Carlos Filipe ,  Michael Gregory Wolfe

IPC: C12Q1/6816 ,  G01N33/569 ,  G01N33/543

Abstract: Provided herein are nucleic acid-cleaving catalytic nucleic acid probes, biosensors and lateral flow biosensor devices and methods and kits of using the probes, biosensors and lateral flow biosensor devices for detecting an analyte present on or generated from a microorganism in a test sample, including Helicobacter pylori and methods for determining whether a subject has a Helicobacter pylori infection.

公开(公告)号：US11543398B2

公开(公告)日：2023-01-03

申请号：US16667559

申请日：2019-10-29

Applicant: McMaster University

Inventor： Sang-Tae Kim ,  Nicolas Randazzo ,  Martin Knyf

IPC: G01N33/18 ,  H01J49/30

Abstract: The present application relates to a method for improving analytical efficiency and cost effectiveness of oxygen isotope analysis of an aqueous sample. In particular, the present application relates to a method of determining an oxygen isotope composition of an aqueous sample by (a) equilibrating the aqueous sample with CO2 gas wherein the aqueous sample comprises an effective amount of carbonic anhydrase (CA) enzyme; and (b) measuring the oxygen isotope composition of the CO2 at equilibrium, wherein the oxygen isotope composition of the CO2 corresponds to the oxygen isotope composition of the aqueous sample.

公开(公告)号：US20220317082A1

公开(公告)日：2022-10-06

申请号：US17441169

申请日：2020-03-20

Applicant: MCMASTER UNIVERSITY

Inventor： Leyla SOLEYMANI ,  Richa PANDEY ,  Yingfu LI ,  Todd HOARE ,  Dingran CHANG ,  Yang LU

IPC: G01N27/327 ,  G01N33/543 ,  C12Q1/6804 ,  C12Q1/6825

Abstract: The present application relates to a biosensor for detecting an analyte comprising a first and second working electrode; a detection probe functionalized on the first working electrode, the detection probe comprising a reporter moiety and a recognition moiety for an analyte; a capture probe functionalized on the second working electrode; and a counter electrode. Each working electrode is configured to provide a change in signal if the analyte is present. The biosensor can be used to detect an analyte in a sample.

公开(公告)号：US20220306122A1

公开(公告)日：2022-09-29

申请号：US17210798

申请日：2021-03-24

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  McMaster University

Inventor： Baik Hoh ,  Seyhan Ucar ,  Kentaro Oguchi ,  Hao Yang

IPC: B60W40/08 ,  G08G1/16 ,  G08G1/052 ,  B60W30/14 ,  B60W30/18 ,  B60W60/00 ,  G05D1/02

Abstract: A method for autonomous path planning triggered by freeway rubbernecking includes obtaining gaze directions of drivers of a plurality of connected vehicles in a region of a road. The method also includes determining whether an average speed of the plurality of connected vehicles in the region is less than a predetermined speed. The method further includes controlling mobility of one or more of the plurality of connected vehicles in response to determining that the gaze directions of one or more drivers of the plurality of connected vehicles deviate from the moving direction of the connected vehicles and determining that the average speed of the connected vehicles is less than the predetermined speed.

公开(公告)号：US11453723B1

公开(公告)日：2022-09-27

申请号：US17304924

申请日：2021-06-28

Applicant: McMaster University

Inventor： Jonathan Lorne Bramson ,  Joanne Alicia Hammill ,  Christopher W. Helsen

IPC: C07K16/28 ,  C07K14/73 ,  A61K35/17 ,  A61P35/00 ,  A61K39/00

Abstract: BCMA T cell antigen coupler (TAC) polypeptides having (i) an antigen-binding domain that binds BCMA, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.

公开(公告)号：US20220221418A1

公开(公告)日：2022-07-14

申请号：US17572376

申请日：2022-01-10

Applicant: McMaster University

Inventor： Leyla Soleymani ,  Sudip Saha ,  Amanda Victorious

IPC: G01N27/30 ,  G01N27/12 ,  G01N27/327 ,  G01N27/02 ,  H01G9/20

Abstract: This disclosure relates to a biosensor, and methods of use thereof, for detecting a target in a sample comprising a photoelectrode comprising a conductive substrate and a photoactive material; a population of capture probes functionalized on the photoelectrode wherein the capture probes are capable of binding to the target and a reporter moiety; and the reporter moiety comprising a detectable label and a capture probe binding portion; wherein exposure of the target to the population of the capture probes results in binding of the target to a fraction of the population which results in a decrease in detection signal intensity compared to the intensity in the absence of the target, and subsequent binding of the reporter moiety to the remaining unbound capture probes results in an increase in detection signal intensity that is less than an increase from the reporter moiety binding to capture probes not exposed to the target.