摘要:
A computer system has clients and servers of different object models, such as SOAP, CORBA and EJB for providing distributed application services. To connect a SOAP client to a CORBA or EJB server, a bridge 10 is used containing corresponding server and client components as well as a mapping component to map object and method requests of one type into another.
摘要:
The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C1-5 branched or unbranched alkyl group or a C2-5 alkenyl group; n is 0 or 1; R1 is H, a C1-8 branched or unbranched alkyl group, a C2-8 alkenyl group, or an aryl or aralkyl group; Ar1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.
摘要翻译:本发明涉及式I的双芳基磺酰胺化合物的用途,其中W是C 1-5 - 支链或非支链烷基或C 2-5烯基; n为0或1; R 1是H,支链或非支链烷基,C 2-8链烯基或芳基或芳烷基的C 1-8-18支链或非支链烷基 组; Ar 1是取代的噻吩基,呋喃基,吡咯基,咪唑并噻唑基,噻唑基,吡啶基或苯基; 并且Ar 2是取代的苯基,吲哚基或苯并咪唑基; 在制备用于治疗增殖性疾病的药物中。 本发明的其它方面涉及式I化合物,其药物组合物和用于测定与HDM2结合的测定法。
摘要:
The present invention provides a method and system for session sharing that allows multiple authorized users (e.g., assistants) to access the same session and synchronize the browser views, when the current state changes. Through the use of use of session sharing, it is ensured that all users work on the same data and have the same Web side state. The Client side is kept in synchronization through the use of a publisher-subscriber model that initiates an update of all connected Clients when a state change occurs. These functionalities of the present invention ensure that all participating users can work together and can share the same state both on server and Client side.
摘要:
The invention relates to a scanning device for a position measuring system for scanning a scale graduation with a probe, which can be brought into operative connection with the scale graduation and is supplied with electric power over electrical connections; an electronic module, which is coupled over electric connections to the probe; a housing for the electronic module for thermally shielding the electronic module from the surroundings; and means for limiting the supply of current to the probe. Pursuant to the invention, the electrical connections, leading to the probe, within the housing of the electronic module, have at least one fuse, which interrupts the flow of current to the probe when the temperature produced as a result of the current flow exceeds a specifiable value. The housing the electronic module forms the housing of the fuse.
摘要:
An intake device has a flange, at which it can be attached to a flange of a cylinder head. Intake pipes are furthermore provided, which are configured as at least two inlet ducts per cylinder. At least in the region of the flange of the intake device, the free cross section of at least one of the intake ducts in each case is capable of being closed by a flap. The flange and the flap with a shaft and a bearing are formed in such a way that the flap can be introduced with the shaft and the bearing in front of that side of the flange that faces the cylinder head.
摘要:
The present invention relates to novel pyrazine compounds and their use in the regulation of haematopoiesis, in particular in the stimulation of haematopoiesis, and in the treatment of bacterial, viral and fungal diseases.
摘要:
The present invention relates to peptide of the amino acid sequence of formula (I): 82 85 90 Glu Thr His Lys Asp Asp Gln Leu Ile 95 100 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 105 110 Tyr Cys Ser Asp His Thr Gly Thr Lys Arg 115 120 Ser Cys Arg Cys His Glu Gly Tyr Ser Leu 125 128 Leu Ala Asp Gly Val Ser Cys Thr (SEQ ID NO. 1) and functional equivalents thereof in which amino acids in the above stated sequence are modified or absent and wherein at least one of the cysteine residues may be blocked or replaced and wherein any cysteine residues which remain unblocked or unreplaced may be present in a disulphide bonded state. The invention also includes slats and derivatives of said peptides. The peptides and their salts and derivatives are useful in the treatment of blood clotting disorders.
摘要翻译:PCT No.PCT / GB95 / 02946 Sec。 371日期1997年8月27日第 102(e)日期1997年8月27日PCT提交1995年12月15日PCT公布。 公开号WO96 / 18654 日期:1996年6月20日本发明涉及式(I)的氨基酸序列的肽: - 82 85 90 - Glu Thr His Lys Asp Asp Gln Leu Ile - - 95 100 - Cys Val Asn Glu Asn Gly Gly Cys Glu Gln - - 105 110 - Tyr Cys Ser Asp His Thr Gly Thr Lys Arg - - 115 120 - Ser Cys Arg Cys His Glu Gly Tyr Ser Leu - - 125 128 - Leu Ala Asp Gly Val Ser Cys Thr(SEQ ID NO.1 )和其功能等同物,其中上述序列中的氨基酸被修饰或不存在,并且其中至少一个半胱氨酸残基可被阻断或替换,并且其中保持未阻断或未置换的任何半胱氨酸残基可以存在于二硫键中 州。 本发明还包括所述肽的板条和衍生物。 肽及其盐和衍生物可用于治疗凝血障碍。
摘要:
In accordance with a novel process, (R)-amines of the formula ##STR1## in which R.sup.1, R.sup.2 and n have the meanings given in the description, can be prepared by reacting reating N-acyl-amines of the formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3 and n have the meanings given in the description,with lipases which are suitable for cleaving the (R)-enantiomers of N-acyl-amines of the formula (II), in the presence of water and optionally in the presence of an organic diluent, at a pH of between 3.0 and 10.0 and at temperatures of between 0.degree. C. and 80.degree. C.
摘要:
This invention relates to a process for the preparation of an iron catalyst used for the hydrogenation of organic compounds comprising partially oxidizing iron or an iron alloy in particulate form at an elevated temperature in the presence of gaseous oxygen until a weight gain of from 5% to 32% is obtained; and then reducing the partially oxidized iron or iron alloy at an elevated temperature in a stream of hydrogen.The invention also relates to a process for the preparation of primary amines comprising catalytically hydrogenating nitriles corresponding to said primary amines in the presence of an iron catalyst of the invention.
摘要:
The present invention is an improvement upon a known apparatus for polymerization of a body from dental plastic material by irradiation of the body with radiation of a selected wave length in the range between about 350 nm and about 550 nm. To achieve a desired degree of polymerziation of the dental plastic, a specific amount of radiation must be applied to the body. In order to achieve reproducible irradiation results in spite of fluctuations in supply voltage, alterations in lamp characteristics, burn out of one or more lamps, shifting of spectral outputs, replacement of defective or superannuated lamps, soiling of lamps and reflector surfaces and/or changes of operating temperatures in the irradiation area, a supplemental detection system in provided. Upon beginning of irradiation, a photocell measures a percentage component of the radiation within the selected wave length range from each irradiation source, generates an electrical signal therefrom and the electrical signal is integrated and compared to a predetermined value corresponding to the desired degree of polymerization. When the predetermined value is reached, the irradiation is interrupted.