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1122 条记录 (耗时 0.044 秒)

    Anti-clathrin heavy chain monoclonal antibody for inhibition of tumor angiogenesis and growth and application thereof
    104.
    发明授权
    Anti-clathrin heavy chain monoclonal antibody for inhibition of tumor angiogenesis and growth and application thereof 有权
    抗网格蛋白重链单克隆抗体用于抑制肿瘤血管生成及其生长及应用

    公开(公告)号：US08969530B2

    公开(公告)日：2015-03-03

    申请号：US13644311

    申请日：2012-10-04

    申请人： Academia Sinica

    发明人： Han-Chung Wu ,  Kuo-Hua Tung

    IPC分类号： C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/30

    CPC分类号： C07K16/18 ,  C07K16/303 ,  C07K2317/73

    摘要： A purified monoclonal antibody, or an. antigen-binding portion thereof, which specifically binds to human clathrin heavy chain (CHC) is disclosed. The antibody, or antigen-binding portion, thereof, exhibits at least one, two, three, four, five, six, seven, or all eight of the following properties: (a) specifically binds to pancreatic adenocarcinoma cells; (b) binding to the cell surface and cytosol of cancer cells and tumor blood vessels; (c) internalized by CHC-expressing cells; (d) inhibiting tumor growth, invasion ability, migration, and angiogenesis; (e) inducing apoptosis in cancer cells and human umbilical vein endothelial cells; (f) inhibiting tumor growth and tumor blood vessels in pancreatic cancer in vivo; (g) suppressing epidermal growth factor, transferrin, and VEGF internalizations by cancer cells; and (h) suppressing hypoxia-inducible factor-1α expression and vascular endothelial growth factor secretion. Methods for inhibiting tumor cell growth and/or angiogenesis, and detecting cancer in a subject is also disclosed.

    摘要翻译： 纯化的单克隆抗体，或 公开了与人网格蛋白重链（CHC）特异性结合的抗原结合部分。 抗体或其抗原结合部分显示出以下性质中的至少一种，二种，三种，四种，五种，六种，七种或全部八种：（a）特异性结合胰腺腺癌细胞; （b）结合癌细胞和肿瘤血管的细胞表面和细胞溶质; （c）通过表达CHC的细胞内化; （d）抑制肿瘤生长，侵袭能力，迁移和血管生成; （e）诱导癌细胞和人脐静脉内皮细胞凋亡; （f）体内抑制胰腺癌肿瘤生长和肿瘤血管; （g）抑制癌细胞的表皮生长因子，转铁蛋白和VEGF内化; 和（h）抑制低氧诱导因子-1α表达和血管内皮生长因子分泌。 还公开了抑制肿瘤细胞生长和/或血管发生以及检测受试者中的癌症的方法。

    SOCIAL ACTIVITY PLANNING SYSTEM AND METHOD
    105.
    发明申请
    SOCIAL ACTIVITY PLANNING SYSTEM AND METHOD 有权
    社会活动规划系统与方法

    公开(公告)号：US20150046473A1

    公开(公告)日：2015-02-12

    申请号：US14455384

    申请日：2014-08-08

    申请人： ACADEMIA SINICA

    发明人： De-Nian YANG ,  Chih-Ya SHEN ,  Hong-Han SHUAI ,  Ming-Syan CHEN

    IPC分类号： G06F17/30

    CPC分类号： G06Q50/01 ,  G06Q10/109

    摘要： A social activity planning method includes the following operation. A database storing multiple candidate invitees with their geographical locations and interest scores towards a topic, and a social graph including vertices representing the candidate invitees and edges connecting two vertices representing mutual acquaintance of the associated candidate invitees is accessed. A social activity request including an invitation number, information about a social activity, and a familiarity condition for the social activity request is received. At least one feasible solution including the invitation number of the candidate invitees and meeting the familiarity condition is generated. A group of selected invitees are found based on the feasible solution and the information about the social activity.

    摘要翻译： 社会活动规划方法包括以下操作。 数据库，存储有多个候选受邀者及其与主题相关的地理位置和兴趣分数，以及包括表示候选受邀者的顶点和连接表示相关候选被邀请者相互认识的两个顶点的边缘的社交图。 收到社会活动请求，包括邀请号码，有关社会活动的信息以及社交活动请求的熟悉条件。 生成至少一个可行的解决方案，包括候选人的邀请号和满足熟悉条件。 根据可行的解决方案和有关社会活动的信息，找到一组被选中的被邀请者。

    NANOPARTICLE-ASSISTED ULTRASOUND FOR CANCER THERAPY
    109.
    发明申请
    NANOPARTICLE-ASSISTED ULTRASOUND FOR CANCER THERAPY 有权
    用于癌症治疗的纳米辅助超声波治疗

    公开(公告)号：US20140335156A1

    公开(公告)日：2014-11-13

    申请号：US14253977

    申请日：2014-04-16

    申请人： Academia Sinica

    发明人： Olga K. Kosheleva ,  Peter Lai ,  Nelson G. Chen ,  Michael Hsiao ,  Chung-Hsuan Chen

    IPC分类号： A61K9/00

    CPC分类号： A61K41/0033 ,  A61K41/0028 ,  A61K47/6923 ,  A61N7/00 ,  A61N7/02 ,  Y10S977/773 ,  Y10S977/911

    摘要： Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, PEG, or liposome nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.

    摘要翻译： 通过将细胞暴露于纳米颗粒并用聚焦的低至中等功率超声照射来杀死受试者的癌细胞和治疗癌症的方法。 纳米颗粒可以是金，氧化铁，铜，银，聚苯乙烯，PEG或脂质体纳米颗粒。 纳米颗粒可以具有连接的癌症药物，例如基于抗体的癌症药物。

    Multiplex barcoded paired-end diTag (mbPED) sequencing approach and ITS application in fusion gene identification
    110.
    发明授权
    Multiplex barcoded paired-end diTag (mbPED) sequencing approach and ITS application in fusion gene identification 有权
    多重条码配对端diTag（mbPED）测序方法和ITS在融合基因鉴定中的应用

    公开(公告)号：US08829172B2

    公开(公告)日：2014-09-09

    申请号：US13416764

    申请日：2012-03-09

    申请人： Kuo Ping Chiu ,  Yi Chou ,  Sheng-Chung Chen

    发明人： Kuo Ping Chiu ,  Yi Chou ,  Sheng-Chung Chen

    IPC分类号： C07H21/00 ,  G01N33/487 ,  C12P19/34 ,  C12N15/66 ,  C12N15/65

    CPC分类号： C12N15/66 ,  C12N15/65 ,  C12P19/34

    摘要： A method of generating a barcoded Paired-End Ditag (bPED) nucleic acid fragment is disclosed. The method comprises: a) performing a first ligation by ligating a half-adaptor with one or two 3′-overhanging ends to a target nucleic acid to obtain a nucleic acid fragment with two ends each attached to one of the half-adaptor, the half adaptor comprising a half-barcode and a restriction enzyme (RE) recognition site; b) performing a second ligation by ligating two of the half-adaptor at the two ends of the nucleic acid fragment to form a circularized nucleic acid construct, wherein the circularized nucleic acid construct comprises a full-size barcoded adaptor; and c) digesting the circularized nucleic acid construct with a RE that cleaves at a defined distance from the RE recognition site, and thereby generating the bPED nucleic acid fragment.

    摘要翻译： 公开了一种产生条形码配对末端分析（bPED）核酸片段的方法。 该方法包括：a）通过将半适配子与一个或两个3'-突出末端连接至靶核酸来进行第一次连接，以获得核酸片段，其两端分别连接到半适配器之一， 半适配器，其包含半条形码和限制酶（RE）识别位点; b）通过在核酸片段的两端连接两个半连接体以形成环化的核酸构建体来进行第二次连接，其中所述环化的核酸构建体包含全尺寸条形码适配器; 和c）用在RE识别位点定义的距离处切割的RE消化环化的核酸构建体，从而产生bPED核酸片段。