公开(公告)号：US09005109B2

公开(公告)日：2015-04-14

申请号：US13088133

申请日：2011-04-15

申请人： J. Edward Shapland ,  Robert G. Walsh ,  John David Dockter ,  John C. Vanden Hoek

发明人： J. Edward Shapland ,  Robert G. Walsh ,  John David Dockter ,  John C. Vanden Hoek

IPC分类号： A61F2/00 ,  A61L31/14 ,  A61F2/24 ,  A61L31/00 ,  A61L31/02 ,  A61L31/04 ,  A61L31/06

CPC分类号： A61L31/148 ,  A61F2/2481 ,  A61F2250/0031 ,  A61L31/005 ,  A61L31/022 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  C08L27/16

摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.

公开(公告)号：US20150065977A1

公开(公告)日：2015-03-05

申请号：US14476803

申请日：2014-09-04

申请人： Cook Medical Technologies LLC

发明人： Darin G. Schaeffer

IPC分类号： A61B17/00 ,  A61L31/14 ,  A61F13/20

CPC分类号： A61B17/0057 ,  A61B2017/00654 ,  A61B2017/00898 ,  A61L27/3633 ,  A61L31/146 ,  A61L2400/04

摘要： Described are devices useful for providing hemostasis at a vascular access site, and related methods. Such devices can include first and second implant members cooperable when forced together to expand the first implant member in a tissue tract at the site. Such devices can also include an anchor member and a tether attached thereto. The anchor member can be deployed distally to the first implant member, within a vessel, and the tether can be tensioned to apply counterforce to the first implant member as the second implant member is forced into cooperative contact to expand the first implant member.

摘要翻译： 描述了用于在血管通路部位提供止血的装置及相关方法。 这种装置可以包括第一和第二植入物构件，当第一和第二植入物构件被强制在一起时，该第一和第二植入物构件在该部位的组织管道中扩张第一植入物构件。 这样的装置还可以包括锚固构件和与其连接的系绳。 锚定构件可以在容器内向远端部署到第一植入构件，并且当第二植入构件被强制进行协作接触以使第一植入构件膨胀时，系绳可被张紧以向第一植入构件施加反作用力。

公开(公告)号：US20150032202A1

公开(公告)日：2015-01-29

申请号：US14444251

申请日：2014-07-28

申请人： New York University

发明人： Omar Tanweer ,  Vittoria Flamini

IPC分类号： A61L31/16 ,  A61F2/90

CPC分类号： A61L31/16 ,  A61F2/90 ,  A61F2250/0023 ,  A61F2250/0039 ,  A61F2250/0067 ,  A61L31/146 ,  A61L2300/416 ,  A61L2300/44

摘要： A drug-eluting stent is disclosed, the stent having an outer cylindrical portion, an inner cylindrical portion disposed within and substantially coaxial with the outer cylindrical portion, a plurality of cross-links connecting the inner cylindrical portion to the outer cylindrical portion, and a first drug affixed to the inner and/or outer cylindrical portions. The stent may further comprise a second drug affixed to the inner and/or outer cylindrical portions. Methods are disclosed for use of a drug-eluting stent for treatment of a region of interest which is located away (downstream) from the location of the stent. Methods are disclosed for the use of the dual drug-eluting stent to provide therapy and adjunctive therapy protocols.

摘要翻译： 公开了一种药物洗脱支架，该支架具有外圆柱形部分，设置在外圆柱形部分内并基本上与外圆柱形部分同轴的内圆柱形部分，连接内圆柱部分与外圆柱形部分的多个交叉连接， 第一药物固定在内圆柱形部分和/或外部圆柱形部分上。 支架还可以包括固定到内圆柱形部分和/或外部圆柱形部分上的第二药物。 公开了使用药物洗脱支架来治疗远离支架位置（下游）的感兴趣区域的方法。 公开了使用双药物洗脱支架提供治疗和辅助治疗方案的方法。

公开(公告)号：US20150032159A1

公开(公告)日：2015-01-29

申请号：US14336382

申请日：2014-07-21

申请人： Aesculap AG

发明人： Jens Beger ,  Susanne Klingseis

IPC分类号： A61B17/70 ,  A61B17/86

CPC分类号： A61B17/7032 ,  A61B17/686 ,  A61B17/7059 ,  A61B17/8061 ,  A61B17/8605 ,  A61B17/863 ,  A61B17/864 ,  A61L31/06 ,  A61L31/088 ,  A61L31/146 ,  A61L2430/38 ,  C08L71/12

摘要： A system for anchoring a pedicle screw in a patient's vertebra uses a pedicle screw having a threaded portion sinkable in the vertebral arch. The space between the threaded portion and cortical edge layer of the pedicle is at least partially filled by a spacer that enables an all-round support of the threaded portion at the cortical edge layer. A kit includes a pedicle screw and a spacer which at least partially fills the space between the threaded portion and cortical edge layer of the pedicle. A spacer has an essentially oval cross-section for form-locking fit in a corresponding axial recess sunk in the pedicle and having an axial through-hole to accommodate the threaded portion of a pedicle screw, as well as a spacer in the form of an essentially cylindrical pedicle augmentation in the form of a bone screw or a bone bracket.

摘要翻译： 用于将椎弓根螺钉固定在患者椎骨中的系统使用具有可在椎弓下沉的螺纹部分的椎弓根螺钉。 椎弓根的螺纹部分和皮质边缘层之间的空间至少部分地由能够在皮质边缘层处的螺纹部分全面支撑的间隔件填充。 套件包括椎弓根螺钉和间隔件，其至少部分地填充椎弓根的螺纹部分和皮质边缘层之间的空间。 间隔件具有基本上椭圆形的横截面，用于在椎弓根内凹入的相应的轴向凹槽中的形状锁定配合，并且具有轴向通孔以容纳椎弓根螺钉的螺纹部分，以及间隔件 以骨螺钉或骨支架形式的基本上圆柱形的椎弓根增大。

公开(公告)号：US20150032088A1

公开(公告)日：2015-01-29

申请号：US14374094

申请日：2013-01-24

申请人： The Methodist Hospital Research Institute ,  Baylor College of Medicine

发明人： Alessandro Grattoni ,  Ganesh Subramanyam Palapattu ,  Mohit Khera

IPC分类号： A61M31/00 ,  A61K31/198 ,  A61K31/568

CPC分类号： A61M31/002 ,  A61K9/0024 ,  A61K31/198 ,  A61K31/568 ,  A61L31/022 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2400/12 ,  A61M5/14276 ,  C08L71/00

摘要： Implantable devices and methods for delivering pharmaceutical substances into a patient. The implantable device includes the following components: (a) an implant body, (b) a reservoir in the implant body, (c) a heterogeneous composition disposed in the reservoir, which includes a pharmaceutical substance in the solid state contacted by a solution of the pharmaceutical substance, and (d) a nanochannel membrane for delivering the pharmaceutical substance from the reservoir to a patient. Extended, high-quality delivery of low solubility drugs such as hormones and chemotherapeutic agents are achieved.

摘要翻译： 用于将药物物质输送到患者体内的可植入装置和方法。 可植入装置包括以下部件：（a）植入物主体，（b）植入物主体中的储存器，（c）设置在储存器中的非均质组合物，其包括固体状态的药物物质， 药物物质，和（d）用于将药物从储存器输送到患者的纳米通道膜。 实现了高质量的低溶解度药物如激素和化学治疗剂的输送。

公开(公告)号：US20150010422A1

公开(公告)日：2015-01-08

申请号：US13935261

申请日：2013-07-03

申请人： Medtronic Vascular, Inc.

发明人： Stephen Nash

IPC分类号： A61L27/54 ,  A61F2/86 ,  B22F5/10

CPC分类号： A61F2/86 ,  A61F2240/005 ,  A61L31/022 ,  A61L31/146 ,  A61L31/16 ,  B22F5/10 ,  B22F5/106 ,  B22F2003/247 ,  B22F2005/103

摘要： Methods for manufacturing an endovascular stent having channel(s) formed therein for containing a therapeutic material. A molding and sintering process forms a thin-walled tubular component having a tubular core structure encapsulated therein. Portions of the thin-walled tubular component are removed to form at least a portion of the endovascular stent in a pattern corresponding to that of the tubular core structure such that the tubular core structure or corresponding channel(s) left thereby are captured within a wall of the formed stent. The tubular core structure is removed to leave a corresponding channel(s) in its stead. A plurality of holes is formed in the stent wall for filling the stent channel(s) with the therapeutic material and for eluting the therapeutic material therefrom.

摘要翻译： 用于制造其中形成有通道以容纳治疗材料的血管内支架的方法。 模制和烧结工艺形成了一种其中封装有管状芯结构的薄壁管状部件。 除去薄壁管状部件的部分以形成对应于管状芯结构的图案的血管内支架的至少一部分，使得由此留下的管状芯结构或相应的通道被捕获在壁 的形成的支架。 去除管状核心结构以留下相应的通道。 在支架壁中形成多个孔，用于用治疗材料填充支架通道并从其中洗脱治疗材料。

公开(公告)号：US08906403B2

公开(公告)日：2014-12-09

申请号：US11719386

申请日：2005-11-15

申请人： Bernard Martel ,  Nicolas Blanchemain ,  François Boschin ,  Stephan Haulon ,  Elisabeth Delcourt Debruyne ,  Michel Morcellet ,  Hartmut Friederich Hildebrand

发明人： Bernard Martel ,  Nicolas Blanchemain ,  François Boschin ,  Stephan Haulon ,  Elisabeth Delcourt Debruyne ,  Michel Morcellet ,  Hartmut Friederich Hildebrand

IPC分类号： A61L27/54 ,  A61K47/34 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61L27/56 ,  A61L31/16 ,  A61L29/16 ,  A61L31/10 ,  A61L27/34 ,  A61L31/14 ,  A61L29/14 ,  A61L29/08 ,  A61K47/48 ,  B82Y5/00

CPC分类号： A61L29/146 ,  A61K47/6951 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/802 ,  B82Y5/00 ,  C08L5/16

摘要： A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es), at least one poly(carboxylic) acid, and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes; c) washing with water; d) drying, wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.

摘要翻译： 一种从基础生物材料制备含有至少一种生物活性分子的生物材料的方法，其包括在基础生物材料上进行的以下连续操作：a）施加以下固体混合物：环糊精和/或环糊精衍生物， 和/或环糊精包合物和/或环糊精衍生物包合物，至少一种聚（羧酸）和任选的催化剂; b）在100℃至200℃的温度下加热1至60分钟; c）用水洗; d）干燥，其中通过在生物活性剂的浓缩溶液中的干燥步骤之后通过浸渍生物材料将至少一种生物活性剂并入生物材料中。

公开(公告)号：US20140309725A1

公开(公告)日：2014-10-16

申请号：US14314777

申请日：2014-06-25

申请人： INSPIREMD, LTD

发明人： Eli Bar ,  Asher Holzer ,  Ofir Paz

IPC分类号： A61F2/90 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61F2/90 ,  A61F2/0063 ,  A61F2/07 ,  A61F2/82 ,  A61F2/89 ,  A61F2002/0086 ,  A61F2002/075 ,  A61F2002/823 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2420/02 ,  C08G63/00 ,  C08G63/06 ,  C08G63/08 ,  C08G63/40 ,  C08G73/02 ,  C08G79/04 ,  Y10T29/49964

摘要： A stent assembly including a stent configured to be positioned in a body lumen, and a knitted stent jacket including an expansible mesh structure having a coverage area of less than 25%, having approximate aperture diameters greater than 20 micrometers, and surrounding an external surface of the stent and coaxially associated therewith, wherein the stent assembly elutes an amount of an active pharmaceutical agent.

摘要翻译： 一种支架组件，其包括构造成定位在体腔中的支架，以及包括具有小于25％的覆盖面积的可膨胀网状结构的针织支架护套，具有大约20微米的孔径直径，并且包围 所述支架并与其共轴相关，其中所述支架组件洗脱一定量的活性药剂。

公开(公告)号：US08852623B2

公开(公告)日：2014-10-07

申请号：US13525193

申请日：2012-06-15

申请人： Rajesh A. Patel ,  Louis R. Bucalo ,  Lauren Costantini ,  Sofie Kleppner

发明人： Rajesh A. Patel ,  Louis R. Bucalo ,  Lauren Costantini ,  Sofie Kleppner

IPC分类号： A61K9/00 ,  A61K31/48 ,  A61K9/16 ,  A61L31/16 ,  A61K31/485 ,  A61K31/381 ,  A61K31/428 ,  A61K31/4045 ,  A61K9/14 ,  A61L31/04

CPC分类号： A61L31/16 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1635 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/48 ,  A61K31/485 ,  A61L31/048 ,  A61L31/10 ,  A61L31/125 ,  A61L31/146 ,  A61L2300/20 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2420/04 ,  C08L31/04

摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.

摘要翻译： 本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。 本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。 多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。 该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

公开(公告)号：US20140296922A1

公开(公告)日：2014-10-02

申请号：US14225068

申请日：2014-03-25

申请人： Kensey Nash Corporation

发明人： Timothy A. Ringeisen

IPC分类号： A61B17/80

CPC分类号： A61B17/8061 ,  A61B17/80 ,  A61B17/8085 ,  A61B2017/00004 ,  A61L31/04 ,  A61L31/125 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/00

摘要： A bendable polymer tissue fixation device suitable to be implanted into a living body, consisting of a highly porous body, made from a polymer, the porous body having a plurality of pores, such that the device is capable of being smoothly bent, wherein the bending collapses a portion of the pores to form a radius curve, and the polymer fixation device is rigid enough to protect a tissue from shifting. Preferably, the polymer fixation device may be capable of being gradually resorbed by said living body. In one embodiment, the polymer fixation device consists of a plurality of layers distinguishable by various characteristics, such as structural or chemical properties. In another embodiment, the polymer fixation device may feature additional materials which serve to reinforce or otherwise alter the structure or physical characteristics of the device, or alternatively the additional materials serve to deliver therapies to the living being.

摘要翻译： 一种可弯曲聚合物组织固定装置，适合于植入由聚合物制成的高度多孔体的活体中，所述多孔体具有多个孔，使得该装置能够平滑弯曲，其中弯曲 塌陷一部分孔以形成半径曲线，并且聚合物固定装置足够刚性以保护组织免于移动。 优选地，聚合物固定装置可能能够被所述活体逐渐吸收。 在一个实施方案中，聚合物固定装置由可由各种特性区分的多个层组成，例如结构或化学性质。 在另一个实施方案中，聚合物固定装置可以具有附加材料，其用于加强或以其它方式改变装置的结构或物理特性，或者替代地，附加材料用于向生物提供疗法。