公开(公告)号：US20240149236A1

公开(公告)日：2024-05-09

申请号：US18547388

申请日：2021-11-19

Applicant: NOURYON CHEMICALS INTERNATIONAL B.V.

Inventor： Bo ANDREASSON ,  Roel WIJTMANS ,  Elwin SCHOMAKER ,  Helena BERGENUDD

IPC: B01J13/04

CPC classification number: B01J13/043

Abstract: Thermally expandable microspheres include a polymeric shell surrounding a hollow core, wherein the hollow core comprises a blowing agent, and the polymeric shell comprises an acetate-functionalised cellulose having a glass transition temperature of from about 150 to about 250° C. and a hydrogen bond donor chosen from alcohols, urea, and carboxylic acids. The microspheres are formed using a process including the step of mixing an acetate-functionalised cellulose, an organic solvent, a blowing agent and a hydrogen bond donor to form a mixture and then spraying the mixture into drying equipment to produce the thermally expandable microspheres.

公开(公告)号：US11896716B2

公开(公告)日：2024-02-13

申请号：US16759925

申请日：2018-10-30

Applicant: ROQUETTE AMERICA, INC.

Inventor： Carmen Popescu

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/17 ,  A61K31/21 ,  A61K31/355 ,  A61K45/00 ,  A61K45/06 ,  A61K47/36 ,  A61K47/44 ,  B01J13/04 ,  B05B5/00 ,  A61J3/02 ,  A61J3/06 ,  A61J3/07 ,  A61J3/10 ,  A23D9/05 ,  A23D7/005 ,  A23D9/007

CPC classification number: A61K9/1682 ,  A23D7/0053 ,  A23D9/007 ,  A23D9/05 ,  A61J3/02 ,  A61J3/06 ,  A61J3/07 ,  A61J3/074 ,  A61J3/10 ,  A61K9/16 ,  A61K9/167 ,  A61K9/20 ,  A61K9/2095 ,  A61K31/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K31/07 ,  A61K31/122 ,  A61K31/17 ,  A61K31/21 ,  A61K31/355 ,  A61K45/00 ,  A61K45/06 ,  A61K47/36 ,  A61K47/44 ,  B01J13/043 ,  B05B5/001

Abstract: The invention relates to a new method for the formulation of oily substances, and to powders and solid dosage forms obtainable thereof. The process comprises a step of spray-drying of an oil-in-water emulsion comprising an octenyl succinate starch and a maltodextrin.

公开(公告)号：US20240003058A1

公开(公告)日：2024-01-04

申请号：US18039322

申请日：2022-01-20

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Matthew Green ,  Mani Modayil Korah

IPC: D01D5/00 ,  B01J13/04 ,  B01J13/12 ,  D01D1/02 ,  D01D5/24

CPC classification number: D01D5/0038 ,  B01J13/043 ,  B01J13/125 ,  D01D1/02 ,  D01D5/24

Abstract: Systems and methods for preparing encapsulant-containing polymer capsules and fibers, as well as the encapsulant-containing polymer capsules and fibers and composites including the same are described. In one example, forming a plurality of encapsulant-containing polymer capsules includes preparing a mixture comprising a polymer, a solvent, an encapsulant, and a polymer that is soluble in the solvent, and removing some of the solvent from the mixture to yield the plurality of polymer capsules. Each polymer capsule include a shell formed of the polymer and contains the encapsulant. In another example, forming a plurality of polymer fibers containing an encapsulant includes providing the mixture to an electrospin apparatus and electrospinning the mixture to yield the plurality polymer fibers, where each polymer fiber defines a hollow core that contains the encapsulant.

公开(公告)号：US20230287224A1

公开(公告)日：2023-09-14

申请号：US18018392

申请日：2021-07-29

Applicant: Chao LI ,  Xiaolei GUO ,  Gerald FRANKEL ,  Ohio State Innovation Foundation

Inventor： Chao LI ,  Xiaolei GUO ,  Gerald FRANKEL

IPC: C09D5/08 ,  C09D129/14 ,  B01J13/10 ,  B01J13/04

CPC classification number: C09D5/084 ,  C09D129/14 ,  B01J13/10 ,  B01J13/043

Abstract: A pH-sensitive release system comprising a capsule capable of releasing an agent in both low pH environments and high pH environments. The capsule encapsulates an SrCrO4 agent and comprises at least two weak polyelectrolytes (e.g., PEI and PAA). The capsule responds to both low and high pH changes in the local environment by releasing the agent. The agent may include a corrosion inhibitor and may help prevent or ameliorate the effects of corrosion.

公开(公告)号：US20230220177A1

公开(公告)日：2023-07-13

申请号：US17999236

申请日：2021-05-19

Applicant: NOURYON CHEMICALS INTERNATIONAL B.V.

Inventor： Bo ANDREASSON ,  Roel WIJTMANS ,  Elwin SCHOMAKER ,  Helena BERGENUDD

IPC: C08J9/18 ,  C08J9/00 ,  C08J9/14 ,  B01J13/04 ,  B01J13/14

CPC classification number: C08J9/18 ,  C08J9/0061 ,  C08J9/141 ,  B01J13/043 ,  B01J13/14 ,  C08J2301/14 ,  C08J2367/02 ,  C08J2203/14 ,  C08J2203/22

Abstract: The present disclosure relates to thermally expandable microspheres comprising a polymeric shell surrounding a hollow core, wherein the hollow core comprises a blowing agent, and the polymeric shell comprises a carboxylate-functionalised cellulose, wherein the thermally expandable microspheres have a temperature at which expansion starts, TStart, of from 80° C. to less than 135° C. The present disclosure further relates to a process for preparing expandable microspheres as well as to thermally expandable microspheres obtained by such process, the process comprising mixing a carboxylate-functionalised cellulose, an organic solvent, a blowing agent and, optionally, a polymer shell enhancer and then spraying the thus obtained mixture into a drying equipment to produce the thermally expandable microspheres having a polymeric shell surrounding a hollow core, in which the polymeric shell comprises the carboxylate-functionalised cellulose, and the hollow core comprises the blowing agent.

公开(公告)号：US20230173075A1

公开(公告)日：2023-06-08

申请号：US17997276

申请日：2021-04-29

Applicant: Kansas State University Research Foundation

Inventor： Yong-Cheng Shi ,  Zhenhua Sun

IPC: A61K47/36 ,  A61K31/216 ,  A61K31/12 ,  A61K9/16 ,  A61K9/107 ,  A61K47/44 ,  B01J13/04

CPC classification number: A61K47/36 ,  A61K31/216 ,  A61K31/12 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/1075 ,  A61K47/44 ,  B01J13/043

Abstract: Compounds encapsulated with octenylsuccinic anhydride modified starch and methods of forming the encapsulated compounds are provided. Poorly water-soluble compounds, especially pharmaceuticals, are solubilized within an oil phase, which is then formed into an emulsion with an aqueous phase comprising the OSA modified starch. The resulting emulsion can be dried, such as through spray drying, for form a powder comprising the encapsulated compound.

公开(公告)号：US20180161745A1

公开(公告)日：2018-06-14

申请号：US15574561

申请日：2016-05-25

Applicant: Givaudan, S.A.

Inventor： Robert GUISINGER ,  Mary Amanda MCKEE ,  Theodore T. PEARL ,  James R. WORKS

IPC: B01J13/04 ,  B01J2/02 ,  B01J2/00

CPC classification number: B01J13/043 ,  B01D1/18 ,  B01J2/003 ,  B01J2/006 ,  B01J2/02 ,  B01J2/04

Abstract: A method of preparing dry core-shell microcapsules from an aqueous dispersion of such capsules, comprising spraying the dispersion through a two-fluid air-liquid nozzle into a heated chamber having an upper part and a lower part, the spraying taking place in the upper part and the lower part being provided with a means of continuous capsule removal. The method allows the drying of capsules with considerably reduced losses.

公开(公告)号：US20180119088A1

公开(公告)日：2018-05-03

申请号：US15565558

申请日：2016-03-24

Applicant: HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGR

Inventor： Qi WANG ,  Huan LIU ,  Jianhua GONG ,  Hai YU ,  Qian GUO ,  Shea MILLER ,  Wuwei CUI

IPC: C12N1/04 ,  B01J13/04 ,  A23P10/35 ,  A23K40/30 ,  A61K47/42

CPC classification number: C12N1/04 ,  A23D7/0053 ,  A23D7/05 ,  A23D9/05 ,  A23K40/30 ,  A23L33/135 ,  A23P10/30 ,  A23P10/35 ,  A23V2002/00 ,  A61K9/1652 ,  A61K35/747 ,  A61K47/42 ,  B01J13/043 ,  C12N11/04 ,  A23V2200/224 ,  A23V2200/3204 ,  A23V2250/194 ,  A23V2250/5028 ,  A23V2250/54246 ,  A23Y2220/00

Abstract: Microparticles include a matrix of an encapsulating material, in which are dispersed particles of a low melting point fat and a bioactive material, such as one or more probiotic bacteria. The microparticles are formed by preparing an emulsion of melted low melting point fat in an aqueous mixture of the encapsulating material, cooling the emulsion below the melting point of the low melting point fat, dispersing the bioactive material in the emulsion and spray drying the emulsion. The particles of solid low melting point fat are believed to protect the bioactive material from heat damage during the spray drying process.

公开(公告)号：US09808424B2

公开(公告)日：2017-11-07

申请号：US13791569

申请日：2013-03-08

Applicant: Pacira Pharmaceuticals, Inc.

Inventor： Ernest George Schutt ,  Ronald Warren McGuire ,  Peter Andrew Walters ,  Kathleen D. A. Los

IPC: A61K9/48 ,  B01D1/16 ,  B01J13/02 ,  A61K9/127 ,  A61K31/4458 ,  B01F3/08 ,  B01F5/10 ,  B01F7/00 ,  A61M11/00 ,  B01J13/04 ,  B01J13/12 ,  A61K31/445 ,  B01F3/04 ,  B01F15/06

CPC classification number: A61K9/1271 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/4833 ,  A61K31/445 ,  A61K31/4458 ,  A61M11/00 ,  B01D1/16 ,  B01F3/04049 ,  B01F3/0807 ,  B01F3/088 ,  B01F5/104 ,  B01F7/0075 ,  B01F15/065 ,  B01F2015/061 ,  B01F2215/0032 ,  B01J13/043 ,  B01J13/125

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

公开(公告)号：US20170305082A1

公开(公告)日：2017-10-26

申请号：US15512694

申请日：2015-09-30

Applicant: LG CHEM, LTD.

Inventor： In Young KIM ,  Jin Yeong LEE ,  Kwon Nam SOHN ,  Eui Yong HWANG ,  Won Jong KWON

IPC: B29C71/02 ,  B01J13/04 ,  B82Y40/00 ,  B29L22/00 ,  B82Y30/00

CPC classification number: B29C71/02 ,  B01J13/043 ,  B29L2022/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/05 ,  C01B32/174 ,  C01P2004/34 ,  C01P2006/16 ,  Y10S977/742 ,  Y10S977/842

Abstract: The present invention relates to a method of producing hollow carbon capsules which can simply and effectively produce hollow carbon capsule by using polymer particles as soft templates and using a spray-drying method.