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公开(公告)号:US20190324023A1
公开(公告)日:2019-10-24
申请号:US15958241
申请日:2018-04-20
Inventor: Yuki Ichikawa , Kiyotaka Shiba , Sachiko Matsumura
IPC: G01N33/543
Abstract: The present disclosure provides examples of methods and kits for easily detecting, classifying and/or purifying extracellular vesicles. The method can include subjecting, to a density gradient centrifugation, a sample solution in which the extracellular vesicles and nanoparticles coated with ligand that specifically binds to molecule present on the surface of the extracellular vesicles are mixed.
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112.
公开(公告)号:US10454238B2
公开(公告)日:2019-10-22
申请号:US15725849
申请日:2017-10-05
Applicant: IMRA America, Inc.
Inventor: Martin E. Fermann , Naoya Kuse
IPC: H01S3/13 , H01S3/067 , H01S3/00 , H03B17/00 , H01S3/107 , H01S3/11 , H01S3/136 , H01S3/23 , H03D7/14 , H03F3/08 , H03L7/24
Abstract: Low phase noise radio frequency (RF) sources generated by voltage controlled oscillators (VCOs) are described. Optical modulators driven by a VCO may be used to generate optical side-bands to cw lasers. The spectral extent of said side-bands can be increased via frequency broadening in highly nonlinear waveguides. Free running mode locked low phase noise comb oscillators can be used as reference oscillators to generate beat signals between those side-bands and individual comb modes at distal spectral regions, thereby creating an error signal used to reduce the phase noise of VCOs and the generation of low phase noise RF signals. VCO phase noise may be reduced by using free-running modelocked comb lasers phase locked to external frequency references, by omitting a reference comb and using a nonlinear interferometer for generating an error signal, or by locking a slave comb to the modulation frequency of an intra-cavity modulator driven by the VCO.
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113.
公开(公告)号:US20190190224A1
公开(公告)日:2019-06-20
申请号:US16218065
申请日:2018-12-12
Applicant: IMRA America, Inc.
Inventor: Kevin F. Lee , Martin E. Fermann
CPC classification number: H01S3/06712 , H01S3/0085 , H01S3/06737 , H01S3/08059 , H01S3/094019 , H01S3/2383
Abstract: In an example amplifier system, an input pulse train is passed through an optical stage that splits each pulse into two or more pulses. These divided pulses are then injected into at least two amplifiers for amplification. The amplified pulses are subsequently passed back through the same optical stage in order to combine the pulses back into one high energy pulse. The amplifier system can use time division multiplexing (TDM) and/or spatial division multiplexing (SDM) to produce, e.g., four pulses in conjunction with two amplifiers and propagation through two optical beam splitters, which are coherently combined into a single output pulse after amplification. The amplifiers can comprise fiber amplifiers or bulk amplifiers.
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公开(公告)号:US10184025B2
公开(公告)日:2019-01-22
申请号:US14161773
申请日:2014-01-23
Applicant: IMRA AMERICA, INC.
Inventor: Yuki Ichikawa , Andrius Marcinkevicus , Masayuki Ito , Wei Qian
IPC: B01J13/00 , C08G65/328 , B82Y30/00
Abstract: The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.
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公开(公告)号:US10036850B2
公开(公告)日:2018-07-31
申请号:US15146693
申请日:2016-05-04
Applicant: IMRA America, Inc.
Inventor: Shigeru Suzuki , Hugh A. McKay , Martin E. Fermann
CPC classification number: G02B6/024 , G02B6/02009 , G02B6/02042 , G02B6/02314 , G02B6/02319 , G02B6/02342 , G02B6/02357 , G02B6/03694
Abstract: This disclosure relates to polarizing optical fibers and polarization maintaining optical fibers, including active and/or passive implementations. An embodiment includes a polarizing (PZ) optical fiber that includes stress applying parts (SAPs) disposed in a first cladding region, the SAPs comprising a material with a thermal expansion coefficient, αSAP. A core region is at least partially surrounded by cladding features and the SAPs. The core includes glass with a thermal expansion coefficient, αcore. The arrangement of the SAPs satisfies: Rsc=dSAP/Dsc, where Dsc is the SAP center to core center distance, and dSAP is the average SAP diameter, and dα=|αSAP−αcore|, and where Rsc and dα may be sufficiently large to induce stress birefringence into the core and to provide for polarized output. Active fibers in which a portion of the fiber is doped may be implemented for application in fiber lasers, fiber amplifiers, and/or optical pulse compressors.
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公开(公告)号:US10014645B2
公开(公告)日:2018-07-03
申请号:US15356845
申请日:2016-11-21
Applicant: IMRA AMERICA, INC.
Inventor: Donald J. Harter
IPC: H01S3/30 , H01S3/00 , H01S3/067 , H01S3/08 , H01S3/094 , H01S3/10 , H01S3/16 , H04B10/508 , H01S3/11 , H01S3/0941 , G02B6/293 , H01S3/23 , H01S5/00
CPC classification number: H01S3/0057 , G02B6/2932 , G02B6/29374 , H01S3/067 , H01S3/06708 , H01S3/06716 , H01S3/06725 , H01S3/0675 , H01S3/06754 , H01S3/06758 , H01S3/08013 , H01S3/094003 , H01S3/094076 , H01S3/0941 , H01S3/10046 , H01S3/11 , H01S3/1106 , H01S3/1608 , H01S3/1618 , H01S3/2308 , H01S5/0057 , H04B10/508
Abstract: System for converting relatively long pulses from rep-rate variable ultrafast optical sources to shorter, high-energy pulses suitable for sources in high-energy ultrafast lasers. Fibers with positive group velocity dispersion (GVD) and self phase modulation are advantageously employed with the optical sources. These systems take advantage of the need for higher pulse energies at lower repetition rates so that such sources can be cost effective.
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公开(公告)号:US09999865B2
公开(公告)日:2018-06-19
申请号:US14312824
申请日:2014-06-24
Applicant: IMRA America, Inc.
Inventor: Yuki Ichikawa , Andrius Marcinkevicus
CPC classification number: B01J13/0043 , B82Y40/00
Abstract: Disclosed is a method for making a colloidal suspension of precious metal nanoparticles. The method comprises providing a target material comprising a precious metal in a liquid dispersion medium in an ablation container. The dispersion medium has an electrical conductivity within a predetermined conductivity range. Laser pulses are used to generate the nanoparticles from the target in the container. While generating the nanoparticles the electrical conductivity of the dispersion medium is monitored and maintained within the predetermined range and thereby the generated nanoparticles are produced within a predetermined size range. The generated nanoparticles are used to form a colloidal suspension.
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118.
公开(公告)号:US20180048113A1
公开(公告)日:2018-02-15
申请号:US15725849
申请日:2017-10-05
Applicant: IMRA America, Inc.
Inventor: Martin E. Fermann , Naoya Kuse
CPC classification number: H01S3/1304 , H01S3/0014 , H01S3/0057 , H01S3/0078 , H01S3/0085 , H01S3/0092 , H01S3/06712 , H01S3/06791 , H01S3/107 , H01S3/1118 , H01S3/1305 , H01S3/1306 , H01S3/1307 , H01S3/136 , H01S3/2391 , H03B17/00 , H03B2200/009 , H03D7/14 , H03F3/08 , H03L7/24
Abstract: Low phase noise radio frequency (RF) sources generated by voltage controlled oscillators (VCOs) are described. Optical modulators driven by a VCO may be used to generate optical side-bands to cw lasers. The spectral extent of said side-bands can be increased via frequency broadening in highly nonlinear waveguides. Free running mode locked low phase noise comb oscillators can be used as reference oscillators to generate beat signals between those side-bands and individual comb modes at distal spectral regions, thereby creating an error signal used to reduce the phase noise of VCOs and the generation of low phase noise RF signals. VCO phase noise may be reduced by using free-running modelocked comb lasers phase locked to external frequency references, by omitting a reference comb and using a nonlinear interferometer for generating an error signal, or by locking a slave comb to the modulation frequency of an intra-cavity modulator driven by the VCO.
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公开(公告)号:US09819141B2
公开(公告)日:2017-11-14
申请号:US15146675
申请日:2016-05-04
Applicant: IMRA America, Inc.
Inventor: Martin E. Fermann
CPC classification number: H01S3/1112 , H01S3/06712 , H01S3/06725 , H01S3/0675 , H01S3/1055 , H01S3/1067 , H01S3/107 , H01S3/1115 , H01S3/1307 , H01S3/161 , H01S3/1616 , H01S2301/085
Abstract: Examples of robust self-starting passively mode locked fiber oscillators are described. In certain implementations, the oscillators are configured as Fabry-Perot cavities containing an optical loop mirror on one cavity end and a bulk mirror or saturable absorber on the other end. The loop mirror can be further configured with an adjustable line phase delay to optimize modelocking. All intra-cavity fiber(s) can be polarization maintaining. Dispersion compensation components such as, e.g., dispersion compensation fibers, bulk diffraction gratings or fiber Bragg gratings may be included. The oscillators may include a bandpass filter to obtain high pulse energies when operating in the similariton regime. The oscillator output can be amplified and used whenever high power short pulses are required. For example the oscillators can be configured as frequency comb sources or supercontinuum sources. In conjunction with repetition rate modulation, applications include dual scanning delay lines and trace gas detection.
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公开(公告)号:US09774160B2
公开(公告)日:2017-09-26
申请号:US14837619
申请日:2015-08-27
Applicant: IMRA AMERICA, INC.
Inventor: Donald J. Harter
IPC: H01S3/10 , G01J11/00 , H01S3/00 , H01S3/102 , H01S3/108 , H01S3/067 , H01S3/109 , H01S3/13 , H01S3/16
CPC classification number: H01S3/10038 , G01J11/00 , H01S3/0014 , H01S3/005 , H01S3/0057 , H01S3/0064 , H01S3/0078 , H01S3/06754 , H01S3/10023 , H01S3/10061 , H01S3/102 , H01S3/1024 , H01S3/108 , H01S3/109 , H01S3/1305 , H01S3/1618
Abstract: A femtosecond laser based laser processing system having a femtosecond laser, frequency conversion optics, beam manipulation optics, target motion control, processing chamber, diagnostic systems and system control modules. The femtosecond laser based laser processing system allows for the utilization of the unique heat control in micromachining, and the system has greater output beam stability, continuously variable repetition rate and unique temporal beam shaping capabilities.
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