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公开(公告)号：US10788450B2
公开(公告)日：2020-09-29
申请号：US15546671
申请日：2016-01-08
Inventor： Yitao Long , Chan Cao , Yongxu Hu
IPC: C12Q1/6869 , G01N33/487 , G01N27/447
Abstract: A preparation method for an aerolysin nanopore in this disclosure comprises the following steps: (1) pretreatment of an aerolysin; (2) preparation of a lipid bilayer membrane by pulling process; (3) forming of the aerolysin nanopore: the aerolysin nanopore is obtained at a current of 50±5 pA. The aerolysin nanopore prepared in the invention is structurally stable and has a high resolution with the whole internal cavity carried with a positive charge, can be used for detection without modification and is easily operated. Further, the aerolysin nanopore can be applied in DNA sequencing, DNA damage and Micro-RNA detection.
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公开(公告)号：US10787651B2
公开(公告)日：2020-09-29
申请号：US16620525
申请日：2018-04-13
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A Bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene and a recombinant transformant, a method of preparing the monooxygenase by the recombinant expression transformant, and a method of preparing an optically pure chiral sulfoxide by the monooxygenase, in particular to a method of preparing prazole drugs by means of catalyzing the asymmetric oxidation of thioether, a prazole precursor. As compared with other methods of preparing an optically pure sulfoxide, the product produced by the monooxygenase of the present invention as a catalyst has high optical purity, avoids the generation of the byproduct sulfone, and has advantages of mild reaction conditions, simple and convenient operations, easy amplification, etc.
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113.发明授权公开(公告)号：US10774355B2
公开(公告)日：2020-09-15
申请号：US16310741
申请日：2016-06-16
Inventor： Fengqing Wang , Liqin Xu , Yongjun Liu , Haohao Liu , Liangbin Xiong , Dongzhi Wei
Abstract: The present invention relates to a genetically-engineered Mycobacterium strain and a use thereof in the preparation of steroidal compounds. The genetically-engineered Mycobacterium strain is a Mycobacteria which lacks of acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33, wherein acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33 respectively encode proteins as follows: having amino acid sequences according to SEQ ID NOs 4, 6 and 8; derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by preceding protein and having the same function as that of the preceding protein. The present invention constructs a genetically-engineered Mycobacterium strain and applies it in preparing steroidal compounds, thereby enriching the types of valuable intermediates, improving the production efficiency and product quality of steroid drugs, reducing energy consumption in the steroid drugs production, simplifying production steps, and reducing production costs.
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公开(公告)号：US20200248069A1
公开(公告)日：2020-08-06
申请号：US16652208
申请日：2018-09-29
Inventor： Linyong Zhu , Yi Yang , Bingkun Bao , Chenxia Zhang , Dasheng Zhang , Chunyan Bao , Qiuning Lin , Ningfeng Li , Xin Hua , Yongliang Zhao , Renmei Liu , Zhengda Chen , Yuying Sun
IPC: C09K11/07 , G01N33/68 , G01N33/58 , C07C255/23 , C07D263/54 , C07D277/64 , C07D233/96 , C07D307/68 , C07D495/04 , C07D333/60 , C07D413/06 , C07D409/06 , C07D417/06 , C07D215/38 , C07D401/06 , C07D495/14
Abstract: Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence labeling of proteins and can also be used in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.
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公开(公告)号：US10703938B2
公开(公告)日：2020-07-07
申请号：US16064235
申请日：2016-12-16
Applicant: KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD. , SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Zuoxiang Zeng , Xingquan Ma , Zhelong Li
Abstract: A novel hot-melt adhesive and a preparation method thereof are disclosed, and in particular a hot-melt adhesive for bonding aluminum, stainless steel or other metal materials and PVC plastics is disclosed. The specific nylon-type copolyamide is firstly prepared by designing specific raw materials and percentage thereof, and in combination with favorable bonding properties of the nylon-type copolyamide for metals and favorable bonding characteristics of the perchloroethylene resin for PVC, a double screw extruder is utilized to perform sufficient melt blending on the nylon-type copolyamide and the perchloroethylene resin under the synergistic actions of related aids, so that the obtained novel hot-melt adhesive has favorable bonding properties for both metals and PVC.
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Patent Agency Ranking
公开(公告)号：US10689469B2
公开(公告)日：2020-06-23
申请号：US16157974
申请日：2018-10-11
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI FUYUAN RUBBER AND PLASTIC TECHNOLOGY LTD.
Inventor： Anna Zheng , Yong Guan , Dafu Wei , Xiang Xu , Pengfei Zhan , Weixing Liu , Han Shi
IPC: C08F220/14 , C08F2/10 , C08F212/08 , C08F265/06 , C08F287/00 , C08L25/14 , C08L35/06 , C08L77/06 , C08F2/01 , C08F2/44 , C08F212/10 , C08K5/00
Abstract: A method of reactive extrusion copolymerization of vinyl monomer consisting of (1) feeding vinyl monomer or at least one vinyl monomer together with an initiator into the first screw of twin-screw extruder, and modified resin into the subsequent screw section; (2) feeding the above monomer into the screw segment after auto-acceleration zone and feeding the initiator corresponding to the temperature of barrel and micro/nano inorganic modified fillers after the half-life period of the initiator; (3) feeding the antioxidant and anti-UV agent at the end of the polymerization, and then removing unpolymerized monomer and by-products by devolatilization of screw segment; (4) obtaining vinyl copolymer resin with a anticipated molecular weight of 5×102 to 6×105 from the reactive extrusion polymerization by controlling the temperature of different screw segments. The invention which overcomes the existing defects of the free radical polymerization by reactive extrusion technology, can not only meet the requirement of short stay time of reactive extrusion polymerization, combine the functionalization and high performance, but also make it possible to obtain high molecular weight polymers.
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公开(公告)号：US10479798B2
公开(公告)日：2019-11-19
申请号：US15523058
申请日：2015-10-30
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Inventor： Honglin Li , Hualiang Jiang , Yufang Xu , Jia Li , Zhenjiang Zhao , Jingya Li , Hongling Xu , Shiliang Li
IPC: C07D311/60 , C07D311/92 , C07D405/04 , C07D493/04 , A61K31/352 , A61K31/5377 , C07D221/10 , C07D335/04 , C07D417/04
Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.
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公开(公告)号：US10351706B2
公开(公告)日：2019-07-16
申请号：US15756734
申请日：2016-08-30
Inventor： Youjun Yang , Xinran Li , Zuhai Lei , Yi Li
IPC: C07D491/22 , C07D311/96 , C09K11/06 , C09B11/10 , C07D491/20 , C09B11/24 , C09B23/01
Abstract: The invention relates to a near-infrared fluorescent dye and use thereof, and particularly relates to compounds represented by following Formulae A, B and C, wherein each group in the Formulae is described in the specification. Further provided are a dye composition comprising the compound represented by Formula A or Formula B, and a preparation method of the compound represented by Formula A or Formula B. The compound has a maximum absorption wavelength of 880 nm, considerably exceeding maximum absorption wavelengths of the majority of small-molecule near-infrared fluorescent dyes in the prior art. Moreover, the structure thereof does not aggregate even if the concentration thereof is excessively high, thereby having considerably high chemical stability and light stability.
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119.发明申请公开(公告)号：US20180356329A1
公开(公告)日：2018-12-13
申请号：US15324552
申请日：2015-06-15
Inventor： Hualin Wang , Yuan Huang , Yang Qiu , Pengbo Fu , Yanhong Zhang , Zhishan Bai , Qiang Yang , Fengqin He
CPC classification number: G01N15/14 , G01N15/1429 , G01N15/1468 , G01N2015/1075 , G01N2015/1445 , G01P3/38 , G06T7/246 , G06T7/292 , G06T7/70 , G06T2207/10016 , G06T2207/30241 , H04N5/2354 , H04N5/247
Abstract: A method and a device for synchronous high-speed photographing of microparticle rotation in a liquid cyclone field and for determining the rotation velocity of a microparticle in a liquid cyclone field by using a combination of a synchronous high-speed photographing system and a transparent microparticle containing two centrosymmetrically arranged inner cores having the same diameter. The method comprises: using a transparent microparticle comprising two inner cores having the same diameter and arranged centrosymmetrically as a rotation test particle; acquiring synchronously two groups of two dimensional image series of microparticle motion in a liquid cyclone field using two orthogonally arranged high-speed digital cameras; and reconstructing a three dimensional motion trajectory of the microparticle from the two groups of synchronous image series, and determining a rotation velocity of the microparticle in the cyclone field at the same time.
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公开(公告)号：US10130941B2
公开(公告)日：2018-11-20
申请号：US15117426
申请日：2014-02-07
Inventor： Liang Li , Gengnan Li
IPC: B01J23/656 , B01D53/86 , B01J37/03 , B01J37/06 , B01J37/16 , B01J35/00 , B01J35/10 , B01D53/88 , B01J37/04 , B01J37/08 , H01M8/0668
Abstract: Methods and catalyst compositions for oxidizing CO to CO2 at low temperatures are disclosed. In one embodiment, a method of oxidizing CO to CO2 may involve heating a gaseous mixture comprising at least CO and O2 with a catalyst mixture comprising Pd disposed on a Mn3O4 mesoporous support at a temperature of about 0° C. to about 60° C., and wherein the CO to CO2 conversion rate is about 40% to about 100%.
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