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1167 条记录 (耗时 0.027 秒)

    PRRS virus inducing type I interferon in susceptible cells
    111.
    发明授权
    PRRS virus inducing type I interferon in susceptible cells 有权
    PRRS病毒诱导I型干扰素在易感细胞中的表达

    公开(公告)号：US09187731B2

    公开(公告)日：2015-11-17

    申请号：US13558669

    申请日：2012-07-26

    申请人： Andreas Gallei

    发明人： Andreas Gallei

    IPC分类号： C12N7/00 ,  A61K39/12 ,  C07K14/005

    CPC分类号： C12N7/00 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/552 ,  C07K14/005 ,  C12N2770/10021 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10062

    摘要： The present invention relates to the field of attenuated live viruses useful as vaccine or medicament for preventing or treating Porcine Reproductive and Respiratory Syndrome (PRRS) in swine, and is based on the surprising finding of a PRRS virus which is able to induce the interferon type I response of a cell infected by said virus. In one embodiment, the PRRS virus according to the invention is a PRRS virus mutant comprising, in comparison with the genome of a wild type strain, a mutation in the gene encoding the non structural protein 1 (nsp1) of said virus.

    摘要翻译： 本发明涉及可用作预防或治疗猪繁殖和呼吸综合征（PRRS）的疫苗或药物的减毒活病毒领域，并且基于能够诱导干扰素型的PRRS病毒的惊人发现 我对所述病毒感染的细胞的反应。 在一个实施方案中，根据本发明的PRRS病毒是PRRS病毒突变体，其与野生型菌株的基因组相比，包含编码所述病毒的非结构蛋白1（nsp1）的基因中的突变。

    Method of treating gastrointestinal diseases associated with species of genus Clostridium
    116.
    发明授权
    Method of treating gastrointestinal diseases associated with species of genus Clostridium 有权
    治疗与梭菌属物种相关的胃肠道疾病的方法

    公开(公告)号：US09168275B2

    公开(公告)日：2015-10-27

    申请号：US11979007

    申请日：2007-10-30

    申请人： Sydney M. Finegold

    发明人： Sydney M. Finegold

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/08 ,  A61K35/745 ,  A61K31/43 ,  A61K31/545 ,  A61K31/7048 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/76 ,  A61K38/00

    CPC分类号： A61K35/745 ,  A61K31/43 ,  A61K31/545 ,  A61K31/7048 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  C12N2795/00032 ,  Y02A50/473 ,  A61K2300/00

    摘要： The invention includes a method of treating gastrointestinal diseases associated with species of genus Clostridium such as clostridium deficit in human patients with gastrointestinal disorders having an etiological component such as a microbial agent producing a toxin where treated with an antimicrobial composition an amount effective to inhibit or eliminate the microbial agent. The antimicrobial composition in a form of probiotic mixture can be administrated alone or in combination with an antimicrobial agent, such as a bacteriophage which is specific for a bacterium producing toxin or antibiotics which are then used to eliminate or inhibit the clostridial species overgrown in a patient's gastrointestinal tract. Disorders that can be treated by the method of the invention include diarrhea or inflammatory bowel diseases such as colitis or Crohn's disease.

    摘要翻译： 本发明包括治疗与梭状芽孢杆菌属物种相关的胃肠道疾病的方法，例如患有胃肠疾病的患有胃肠疾病的病人成分的胃肠疾病，例如产生毒素的微生物剂，其中用抗微生物组合物治疗有效抑制或消除的量 微生物剂。 益生菌混合物形式的抗微生物组合物可以单独施用或与抗微生物剂组合施用，例如对产生细菌的毒素或抗生素特异性的噬菌体，然后用于消除或抑制病毒体中长满的梭菌物种 胃肠道。 可以通过本发明的方法治疗的疾病包括腹泻或炎症性肠病如结肠炎或克罗恩氏病。

    COMPOSITIONS FOR THE RESTORATION OF A FECAL MICROBIOTA AND METHODS FOR MAKING AND USING THEM
    117.
    发明申请
    COMPOSITIONS FOR THE RESTORATION OF A FECAL MICROBIOTA AND METHODS FOR MAKING AND USING THEM 审中-公开
    用于恢复FECAL MICROBIOTA的组合物及其制备和使用它们的方法

    公开(公告)号：US20150297642A1

    公开(公告)日：2015-10-22

    申请号：US14647062

    申请日：2013-11-26

    申请人： Thomas Julius BORODY

    发明人： Thomas Julius BORODY

    IPC分类号： A61K35/38 ,  C12N1/20 ,  A61K45/06 ,  A61K9/19 ,  A61K35/76 ,  A61K35/74

    CPC分类号： A61K35/38 ,  A61K9/19 ,  A61K9/2004 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/606 ,  A61K31/635 ,  A61K31/655 ,  A61K31/706 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K35/76 ,  A61K36/28 ,  A61K36/31 ,  A61K36/48 ,  A61K36/8962 ,  A61K38/40 ,  A61K38/465 ,  A61K38/47 ,  A61K38/51 ,  A61K45/06 ,  A61K2300/00 ,  C12N1/20 ,  C12Y301/21001 ,  C12Y302/01 ,  C12Y302/01052 ,  Y02A50/473

    摘要： In alternative embodiments, the invention provides compositions and methods for treating various disorders and conditions in mammals, including chronic disorders in which there is a presence of an abnormal microbiota or an abnormal distribution of microflora in the gastrointestinal tract. In alternative embodiments, the invention provides liquid preparations or formulations derived from a human fecal material (e.g., a stool) processed, e.g., filtered and/or centrifuged, such that all bacteria, fungal spores and viruses are removed, but retaining the native biologically active molecules from the fecal material and bacteriophages. In alternative embodiments, the invention provides a “rough-”, “incomplete-” or medium-filtered microbiota which still comprises native physiological components or nutritive agents for the bacteria, e.g., retains native biologically and nutritionally active components. In alternative embodiments, the invention provides a highly filtered or substantially purified microbiota in combination with, or having added back, a liquid preparation or formulation of the invention. In alternative embodiments, the invention provides compositions or formulations where the bacteria, or microbiota, component has been cultured, or cultured under anaerobic conditions, or harvested, stored and/or cultured under anaerobic conditions. In alternative embodiments, the invention provides various additives, compositions and donor restrictions for treating these disorders and conditions.

    摘要翻译： 在替代实施方案中，本发明提供用于治疗哺乳动物中各种病症和病症的组合物和方法，包括其中在胃肠道中存在异常微生物群或微生物群落的异常分布的慢性病症。 在替代实施方案中，本发明提供来自人类粪便物质（例如，粪便）的液体制剂或制剂，例如经过过滤和/或离心处理，使得除去所有细菌，真菌孢子和病毒，但保留天然生物学 来自粪便物质和噬菌体的活性分子。 在替代实施方案中，本发明提供了一种“粗”，“不完全”或中等过滤的微生物群，其还包含细菌的天然生理成分或营养剂，例如保留天然生物和营养活性成分。 在替代实施方案中，本发明提供与本发明的液体制剂或制剂组合或加入的高度过滤或基本上纯化的微生物群。 在替代实施方案中，本发明提供其中细菌或微生物组分已经在厌氧条件下培养或培养，或在厌氧条件下收获，储存和/或培养的组合物或制剂。 在替代实施方案中，本发明提供用于治疗这些疾病和病症的各种添加剂，组合物和供体限制。

    Self-complementary parvoviral vectors, and methods for making and using the same
    118.
    发明授权
    Self-complementary parvoviral vectors, and methods for making and using the same 有权
    自身互补的细小病毒载体，以及制备和使用它们的方法

    公开(公告)号：US09150882B2

    公开(公告)日：2015-10-06

    申请号：US11701279

    申请日：2007-01-31

    申请人： Mark A. Kay ,  Dirk Grimm

    发明人： Mark A. Kay ,  Dirk Grimm

    IPC分类号： C12N15/86 ,  A61K48/00

    CPC分类号： C12N15/86 ,  A61K35/76 ,  A61K48/00 ,  A61K48/005 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14143 ,  C12N2750/14152

    摘要： The teachings herein are generally directed to a method of enhancing the genetic stability of parvovirus vectors. The stability of conventional ss or dsAAV vector constructs can be enhanced, for example, to obtain a concurrent increase in vector titer and purity, as well as an improvement in vector safety, due at least in part to the elimination of stuffer DNA from the AAV vector. The method is broadly applicable to all gene transfer/therapy applications, such as those requiring delivery of foreign DNA containing recombinant gene expression cassettes. Such foreign DNA can range, for example, from about 0.2 up to about 5.2 kb in length. The enhanced vector constructs are highly flexible, user-friendly, and can be easily modified (via routine DNA cloning) and utilized (via standard AAV vector technology) by anyone skilled in the art.

    摘要翻译： 本文的教导通常涉及提高细小病毒载体的遗传稳定性的方法。 可以增强常规的ss或dsAAV载体构建体的稳定性，例如，获得载体滴度和纯度的同时增加，以及载体安全性的改善，至少部分是由于从AAV消除填充DNA 向量。 该方法广泛适用于所有基因转移/治疗应用，例如需要递送含有重组基因表达盒的外来DNA的那些。 这样的外源DNA的范围可以是例如约0.2至约5.2kb的长度。 增强的载体构建体是高度灵活的，用户友好的，并且可以容易地修饰（通过常规DNA克隆）并且由本领域技术人员利用（通过标准AAV载体技术）。

    TREATMENT OF INTRACELLULAR BACTERIAL INFECTION
    119.
    发明申请
    TREATMENT OF INTRACELLULAR BACTERIAL INFECTION 有权
    细菌性细菌感染的治疗

    公开(公告)号：US20150250897A1

    公开(公告)日：2015-09-10

    申请号：US14430650

    申请日：2013-09-25

    申请人： FIXED PHAGE LIMITED

    发明人： Michael Mattey ,  James Chadwick

    IPC分类号： A61K47/48 ,  A61K35/76

    CPC分类号： A61K47/48853 ,  A01N63/00 ,  A61K35/76 ,  A61K47/48346 ,  A61K47/48723 ,  A61K47/66 ,  A61K47/6891 ,  A61K47/6921 ,  C12N7/00 ,  Y02A50/402 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  A01N25/04 ,  A01N25/06 ,  A01N25/10 ,  A01N25/24 ,  A01N2300/00

    摘要： An intracellular bacterial infection in a plant or animal is treated by administration to a plant cell or animal cell of a particle to which an infectious bacteriophage is covalently attached, wherein the particle is internalised by the cell. Particles with phage attached and compositions comprising the particles are provided. A formulation, for treatment of a bacterial infection, comprises bacteriophage, liquid carrier and adhesive, which dries so that the adhesive adheres the bacteriophage to a surface, one such formulation comprising liquid carrier: 85%-99.98% by weight; bacteriophage: 0.01%-5% by weight; and adhesive: 0.01%-10% by weight.

    摘要翻译： 植物或动物中的细胞内细菌感染通过施用于感染性噬菌体共价连接的颗粒的植物细胞或动物细胞进行处理，其中所述颗粒被细胞内化。 提供附有噬菌体的颗粒和包含颗粒的组合物。 用于治疗细菌感染的制剂包括噬菌体，液体载体和粘合剂，其干燥，使得粘合剂将噬菌体粘附到表面，一种这样的制剂包含液体载体：85重量％-99.98重量％ 噬菌体：0.01％-5％（重量）; 和粘合剂：0.01重量％-10重量％。

    Control apparatus and method, recording medium and program
    120.
    发明授权
    Control apparatus and method, recording medium and program 有权
    控制装置及方法，记录介质及程序

    公开(公告)号：US09123235B2

    公开(公告)日：2015-09-01

    申请号：US14075318

    申请日：2013-11-08

    申请人： Sony Corporation

    发明人： Hiroshi Kakuda

    IPC分类号： H04N5/765 ,  G08C17/02 ,  A61K39/145 ,  A61K38/00 ,  A61K49/00 ,  A61K35/76 ,  C07K14/005 ,  G08C19/28

    CPC分类号： G08C17/02 ,  A61K35/76 ,  A61K38/00 ,  A61K39/145 ,  A61K49/0004 ,  C07K14/005 ,  G08C19/28 ,  G08C2201/91

    摘要： The present invention relates to a control apparatus and a method, a recording medium and a program, which enable to control at least one first device more efficiently and quickly through the use of a second device. The control apparatus stores at least one first operation panel information corresponding to the at least one first device received from the second device; detects the at least one first device; determines whether the at least one first operation panel information remains stored in the control apparatus; displays at least one first operation panel based on the at least one first operation panel information if the at least one first operation panel information remains stored in the control apparatus; and controls the at least one first device.

    摘要翻译： 本发明涉及一种控制装置和方法，记录介质和程序，其能够通过使用第二装置更有效和快速地控制至少一个第一装置。 控制装置存储与从第二装置接收的至少一个第一装置相对应的至少一个第一操作面板信息; 检测所述至少一个第一装置; 确定所述至少一个第一操作面板信息是否保持在所述控制装置中; 如果所述至少一个第一操作面板信息保持存储在所述控制装置中，则基于所述至少一个第一操作面板显示至少一个第一操作面板; 并控制所述至少一个第一装置。