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145 条记录 (耗时 0.024 秒)

    Process for producing trans-1233zd
    112.
    发明授权
    Process for producing trans-1233zd 有权
    生产反式1233zd的方法

    公开(公告)号：US08653309B2

    公开(公告)日：2014-02-18

    申请号：US13090477

    申请日：2011-04-20

    申请人： Haiyou Wang ,  Hsueh Sung Tung

    发明人： Haiyou Wang ,  Hsueh Sung Tung

    IPC分类号： C07C17/00 ,  C07C21/18 ,  C07C23/00 ,  C07C25/00 ,  C07C21/00 ,  C07C17/25 ,  C07C19/08

    CPC分类号： C07C17/25 ,  C07B2200/09 ,  C07C17/358 ,  C07C17/383 ,  Y02P20/125 ,  C07C21/18

    摘要： Trans-1233zd, the trans-isomer of 1-chloro-3,3,3-trifluoropropene (HCFO-1233zd) can be used as blowing agents, solvents, cleaning agents, as well as monomers of macromolecule compounds, and can be prepared through the dehydrochlorination of 1,1,1-trifluoro-3,3-dichloropropane (HCFC-243fa) with the help of a catalyst. The present invention is directed to an integrated process is proposed to produce trans-1233zd from 243fa, which is consisted of the following four major unit operations: (1) Catalytic dehydrochlorination of 243fa into trans/cis-1233zd, (2) HCl recovery, (3) Catalytic isomerization of cis-1233zd into trans-1233zzd, and (4) Isolation of trans-1233zd.

    摘要翻译： 反式1233zd，1-氯-3,3,3-三氟丙烯（HCFO-1233zd）的反式异构体可用作发泡剂，溶剂，清洗剂以及大分子化合物的单体，并可通过 借助催化剂对1,1,1-三氟-3,3-二氯丙烷（HCFC-243fa）进行脱氯化氢。 本发明涉及从243fa生产反式1233zd的综合方法，其由以下四个主要单元操作组成：（1）将243fa催化脱氯化氢转化成反式/顺式1233zd，（2）HCl回收， （3）顺式1233zd催化异构化为反式-1233zzd，（4）反式-1233zd的分离。

    Preparation and provision of high assay decabromodiphenylethane
    115.
    发明授权
    Preparation and provision of high assay decabromodiphenylethane 有权
    高分析十溴二苯乙烷的制备和提供

    公开(公告)号：US08217207B2

    公开(公告)日：2012-07-10

    申请号：US13204146

    申请日：2011-08-05

    申请人： Saadat Hussain ,  Arthur G. Mack

    发明人： Saadat Hussain ,  Arthur G. Mack

    IPC分类号： C07C25/00

    CPC分类号： C07C1/26 ,  C07C17/10 ,  C07C2529/40 ,  C08K5/03 ,  C07C9/00 ,  C07C19/075

    摘要： High assay, reaction-derived decabromodiphenylethane product is prepared by feeding (i) diphenylethane or (ii) partially brominated diphenylethane having an average bromine number less than about two, or (iii) both of (i) and (ii), into the liquid confines of a reaction mixture. Such reaction mixture is (a) formed from components comprised of excess liquid bromine and aluminum-based Lewis acid bromination catalyst, and (b) maintained at one or more elevated reaction temperatures of from about 45°-90° C., and at least when elevated pressure is needed to keep a liquid state in the reaction mixture at the temperature(s) used, the reaction mixture is at such an elevated pressure, whereby ar-bromination occurs. The feeding is conducted at a rate slow enough to form high assay reaction-derived decabromodiphenylethane product, which is an effective flame retardant.

    摘要翻译： 通过将（i）平均溴数小于约2的（ii）二苯基乙烷或（ii）部分溴化的二苯基乙烷，或（iii）（i）和（ii）两者加入到液体中来制备高分离反应衍生的十溴二苯乙烷产物 反应混合物的限制。 这种反应混合物是（a）由过量的液态溴和铝基路易斯酸溴化催化剂组成的组分形成的，和（b）保持在一个或多个升高的​​反应温度为约45-90℃，至少 当需要提高压力以在反应混合物中使用的温度保持液体状态时，反应混合物处于这样一个升高的压力下，从而发生溴化。 饲料以足够慢的速度进行，以形成高分析反应衍生的十溴二苯乙烷产物，其是有效的阻燃剂。

    Processing of solid brominated aromatic organic compounds containing occluded bromine
    116.
    发明授权
    Processing of solid brominated aromatic organic compounds containing occluded bromine 失效
    含有阻塞溴的固体溴化芳族有机化合物的加工

    公开(公告)号：US08034986B2

    公开(公告)日：2011-10-11

    申请号：US11840302

    申请日：2007-08-17

    申请人： Saadat Hussain ,  Arthur G. Mack

    发明人： Saadat Hussain ,  Arthur G. Mack

    IPC分类号： C07C17/38 ,  C07C25/00 ,  C07C17/00

    CPC分类号： C07C17/38 ,  C07C25/18 ,  C07C41/34 ,  C07C43/29 ,  C09K21/08

    摘要： Solid-state highly brominated compounds such as solid brominated flame retardants with bromine contents of at least about 60 wt % often contain occluded bromine. Because of their high bromine contents, such compounds have relatively low solubility in common organic solvents. Despite this low solubility, the content of occluded bromine in such solid brominated compounds is effectively reduced by agitating a concentrated agitated slurry of the compound in an inert solvent at a suitable temperature for at least about 1 hour. Thereafter, solids with reduced content of occluded bromine are isolated or recovered from the slurry. Novel products having substantially reduced or eliminated occluded bromine contents and other very desirable characteristics are also provided.

    摘要翻译： 固态高度溴化的化合物，例如溴含量至少约60wt％的固体溴化阻燃剂通常含有阻塞的溴。 由于溴含量高，所以这些化合物在常见的有机溶剂中的溶解度相对较低。 尽管这种低溶解度，但是通过在惰性溶剂中在合适的温度下搅拌化合物的浓缩的搅拌浆料至少约1小时，可以有效地降低这些固体溴化化合物中封闭的溴的含量。 此后，从浆液中分离或回收含有减少的阻塞溴含量的固体。 还提供了具有显着降低或消除了阻塞的溴含量和其它非常理想特性的新产品。

    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
    118.
    发明授权
    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates 失效
    用于制备蛋白酪氨酸激酶抑制剂中间体的对映选择性生物转化

    公开(公告)号：US07465842B2

    公开(公告)日：2008-12-16

    申请号：US11213025

    申请日：2005-08-26

    申请人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    发明人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    IPC分类号： C07C21/18 ,  C07C25/08 ,  C07C25/00 ,  C12P41/00

    CPC分类号： C12P41/004 ,  C07B2200/07 ,  C07C33/46 ,  C12P7/22

    摘要： The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

    摘要翻译： 本发明涉及制备1-（2,6-二氯-3-氟苯基）乙醇的对映体纯纯立体异构体的生物催化方法。 公开了制备所需（S） - 对映体的方法，该方法基于酶拆分，化学酯化和化学水解与1-（2,6-二氯-3-氟苯基）乙酯的倒置或立体选择性反应 用生物催化剂如酶或微生物生物还原2,6-二氯-3-氟 - 苯乙酮。 手性（S） - 对映体可用于合成某些对映异构体富集的醚连接的2-氨基吡啶化合物，其有效抑制人类肝细胞生长因子受体的自身磷酸化。

    Method and device for purifying 1,4-bis (bromodifluoromethyl) benzene
    119.
    发明授权
    Method and device for purifying 1,4-bis (bromodifluoromethyl) benzene 有权
    纯化1,4-双（溴二氟甲基）苯的方法和装置

    公开(公告)号：US07465841B2

    公开(公告)日：2008-12-16

    申请号：US10898925

    申请日：2004-07-27

    申请人： Shean-Jeng Jong ,  Chun-Hsu Lin ,  Chao-Chou Tu ,  Chung-Chien Chang

    发明人： Shean-Jeng Jong ,  Chun-Hsu Lin ,  Chao-Chou Tu ,  Chung-Chien Chang

    IPC分类号： C07C17/00 ,  C07C19/00 ,  C07C21/00 ,  C07C23/00 ,  C07C25/00

    CPC分类号： B01D5/0063 ,  B01D3/085 ,  B01D3/10 ,  B01D5/009 ,  C07C17/14 ,  C07C17/386 ,  C07C22/08

    摘要： A method and a device for purifying 1,4-bis(bromodifluoromethyl)benzene are disclosed. In order to solve the problem of hard to purify and separate 1,4-bis(bromodifluoromethyl)benzene crude products, diphenylmethane that has a higher boiling point and does not interact with 1,4-bis(bromodifluoromethyl)benzene is mixed with the 1,4-bis(bromodifluoromethyl)benzene crude products for evaporation. Afterwards, the purity of the vaporized product is detected and only that reaching an expected purity is collected to obtain high-purity 1,4-bis(bromodifluoromethyl)benzene.

    摘要翻译： 公开了用于纯化1,4-双（溴二氟甲基）苯的方法和装置。 为了解决难以纯化和分离1,4-双（溴二氟甲基）苯粗产物的问题，具有较高沸点并且不与1,4-双（溴二氟甲基）苯相互作用的二苯基甲烷与1 ，4-双（溴二氟甲基）苯粗产物蒸发。 之后，检测蒸发产物的纯度，仅收集达到预期纯度的纯度，得到高纯度的1,4-双（溴二氟甲基）苯。