公开(公告)号：US20210069524A1

公开(公告)日：2021-03-11

申请号：US17052906

申请日：2019-05-03

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: A61N5/06 ,  G02C7/04

Abstract: A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

公开(公告)号：US09464033B2

公开(公告)日：2016-10-11

申请号：US14807436

申请日：2015-07-23

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Jennifer Gage ,  Feng Hong

IPC: C07C321/00 ,  C07C215/68 ,  C07D309/06 ,  C07D333/16 ,  C07C211/27 ,  C07C211/30 ,  C07C215/30 ,  C07C215/42 ,  C07C217/14 ,  C07C217/48 ,  C07C217/62 ,  C07C217/72 ,  C07C235/34 ,  C07C237/20 ,  C07C251/40 ,  C07C255/58 ,  C07C323/29 ,  C07C323/36 ,  C07D209/32 ,  C07D213/14 ,  C07D309/10 ,  C07D333/06 ,  C07D335/02 ,  C07C217/64 ,  C07D213/38 ,  C07D309/12 ,  C07C215/28 ,  C07C317/28 ,  C07C323/25

CPC classification number: C07C215/68 ,  C07C211/27 ,  C07C211/30 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/14 ,  C07C217/48 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C235/34 ,  C07C237/20 ,  C07C251/40 ,  C07C255/58 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C323/36 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/32 ,  C07D213/14 ,  C07D213/38 ,  C07D309/06 ,  C07D309/10 ,  C07D309/12 ,  C07D333/06 ,  C07D333/16 ,  C07D335/02

Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

公开(公告)号：US09452153B2

公开(公告)日：2016-09-27

申请号：US14720705

申请日：2015-05-22

Applicant: Acucela, Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Thomas L. Little, Jr. ,  Ryo Kubota

IPC: C07C213/00 ,  A61K31/382 ,  A61K31/138 ,  A61K31/351 ,  A61K31/165

CPC classification number: A61K31/382 ,  A61K31/138 ,  A61K31/165 ,  A61K31/351 ,  C07C211/27 ,  C07C213/00 ,  C07C215/20 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/72 ,  C07C217/74 ,  C07C219/22 ,  C07C225/16 ,  C07C225/18 ,  C07C233/18 ,  C07C235/34 ,  C07C235/54 ,  C07C237/20 ,  C07C237/38 ,  C07C237/40 ,  C07C257/14 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/30 ,  C07D213/38 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D335/02

Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

公开(公告)号：US09421210B2

公开(公告)日：2016-08-23

申请号：US14630897

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuska ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC: C07C211/27 ,  C07C217/18 ,  A61K31/5375 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07D295/03 ,  C07C225/06 ,  C07C323/33 ,  C07D207/06 ,  C07D211/14 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20160193181A1

公开(公告)日：2016-07-07

申请号：US14720705

申请日：2015-05-22

Applicant: Acucela, Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Thomas L. Little, JR. ,  Ryo Kubota

IPC: A61K31/382 ,  A61K31/351 ,  A61K31/165 ,  A61K31/138

CPC classification number: A61K31/382 ,  A61K31/138 ,  A61K31/165 ,  A61K31/351 ,  C07C211/27 ,  C07C213/00 ,  C07C215/20 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/72 ,  C07C217/74 ,  C07C219/22 ,  C07C225/16 ,  C07C225/18 ,  C07C233/18 ,  C07C235/34 ,  C07C235/54 ,  C07C237/20 ,  C07C237/38 ,  C07C237/40 ,  C07C257/14 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D213/30 ,  C07D213/38 ,  C07D309/06 ,  C07D333/16 ,  C07D333/20 ,  C07D335/02

Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供的是胺衍生物化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和失调症的方法，例如年龄相关性黄斑变性和Stargardt氏病。

公开(公告)号：US09314467B2

公开(公告)日：2016-04-19

申请号：US14630889

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuska ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC: C07C211/27 ,  A61K31/137 ,  A61K31/5375 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07D295/03 ,  C07C217/10 ,  C07C225/06 ,  C07C323/33 ,  C07D207/06 ,  C07D211/14 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495

CPC classification number: A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20150239825A1

公开(公告)日：2015-08-27

申请号：US14631763

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas L. Little, JR. ,  Anna Gall ,  Feng Hong

IPC: C07C217/20

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20140275043A1

公开(公告)日：2014-09-18

申请号：US14205117

申请日：2014-03-11

Applicant: Acucela Inc.

Inventor： Vladimir A. Kuksa ,  Mark W. Orme ,  Feng Hong ,  Ryo Kubota

IPC: C07D309/06 ,  C07D335/02 ,  C07D211/26 ,  C07D307/81 ,  C07D307/14 ,  C07D279/02 ,  C07D311/58 ,  C07D207/09 ,  C07D211/76 ,  C07D333/20 ,  C07D209/14 ,  C07D213/38 ,  C07D239/26

CPC classification number: C07D335/02 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/505 ,  C07D207/08 ,  C07D207/09 ,  C07D207/26 ,  C07D209/08 ,  C07D209/14 ,  C07D211/22 ,  C07D211/26 ,  C07D211/60 ,  C07D211/76 ,  C07D211/96 ,  C07D213/30 ,  C07D213/38 ,  C07D233/64 ,  C07D233/96 ,  C07D239/26 ,  C07D279/02 ,  C07D307/12 ,  C07D307/14 ,  C07D307/80 ,  C07D307/81 ,  C07D309/04 ,  C07D309/06 ,  C07D311/04 ,  C07D311/58 ,  C07D333/12 ,  C07D333/16 ,  C07D333/20

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供了取代的3-苯基丙胺衍生物化合物和包含所述化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

公开(公告)号：US20250076682A1

公开(公告)日：2025-03-06

申请号：US18952067

申请日：2024-11-19

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noel FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C7/14 ,  G02C11/04

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20240385467A1

公开(公告)日：2024-11-21

申请号：US18786135

申请日：2024-07-26

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.