公开(公告)号：US10109480B2

公开(公告)日：2018-10-23

申请号：US15599376

申请日：2017-05-18

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/02 ,  C30B25/04 ,  C30B25/18 ,  C30B29/40 ,  C30B23/02 ,  C30B29/42 ,  H01L29/06 ,  H01L29/267 ,  C30B7/00

Abstract: Exemplary embodiments provide materials and methods of forming high-quality semiconductor devices using lattice-mismatched materials. In one embodiment, a composite film including one or more substantially-single-particle-thick nanoparticle layers can be deposited over a substrate as a nanoscale selective growth mask for epitaxially growing lattice-mismatched materials over the substrate.

公开(公告)号：US20180256086A1

公开(公告)日：2018-09-13

申请号：US15913629

申请日：2018-03-06

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Ronen Polsky ,  Philip R. Miller ,  Justin T. Baca

IPC: A61B5/145 ,  A61B5/15

CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150312 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150984 ,  A61B5/15142

Abstract: A microneedle device comprising a hollow microneedle protruding from the rim of an outer open holder can be used for the extraction of interstitial fluid (ISF). Dermal ISF can be extracted with the microneedle device with minimal pain and no blistering for human subjects. Extracted ISF volumes are sufficient for determining transcriptome and proteome signatures. Similar profiles in ISF, serum, and plasma samples, suggest that ISF can be a proxy for direct blood sampling. This minimally-invasive microneedle device enables real-time health monitoring applications using extracted ISF.

公开(公告)号：US20180253640A1

公开(公告)日：2018-09-06

申请号：US15909918

申请日：2018-03-01

Applicant: STC.UNM

Inventor： Alireza Goudarzi ,  Darko Stefanovic ,  Steven Wayde Graves ,  Daniel Kalb

IPC: G06N3/04 ,  G06N3/08

CPC classification number: G06N3/0454 ,  G06N3/0445 ,  G06N3/088 ,  G16H50/00

Abstract: The invention is directed to a hybrid architecture that comprises a stacked autoencoder and a deep echo state layer for temporal pattern discovery in high-dimensional sequence data. The stacked autoencoder plays a preprocessing role that exploits spatial structure in data and creates a compact representation. The compact representation is then fed to the echo state layer in order to generate a short-term memory of the inputs. The output of the network may be trained to generate any target output.

公开(公告)号：US10058099B2

公开(公告)日：2018-08-28

申请号：US15368148

申请日：2016-12-02

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Eunkyung Ji ,  Dimitri Dascier ,  Anand Parthasarathy ,  Thomas S. Corbitt ,  Kirsten Cicotte ,  Elizabeth LeBleu Dirk ,  Xuzhi Zhu

IPC: A01N43/90 ,  A61L15/46 ,  A01N33/12 ,  A01N43/10 ,  A01N25/34 ,  A01N37/10 ,  A61L15/20 ,  D01H7/00

CPC classification number: A01N43/90 ,  A01N25/34 ,  A01N33/12 ,  A01N37/10 ,  A01N43/10 ,  A61L15/20 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/404 ,  D01H7/00 ,  A01N59/00 ,  A01N2300/00

Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

公开(公告)号：US10048272B2

公开(公告)日：2018-08-14

申请号：US15013102

申请日：2016-02-02

Applicant: STC.UNM ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Bruce S. Edwards ,  Larry A. Sklar ,  Clemencia Pinilla ,  Richard A. Houghten ,  Jon R. Appel ,  Marc A. Giulianotti ,  Jose Medina-Franco

IPC: A61K31/497 ,  A61K31/517 ,  A61K31/17 ,  G01N33/68 ,  C07D403/14 ,  A61K31/496 ,  A61K45/06 ,  C07C275/28 ,  C40B30/02 ,  G01N33/74 ,  A61K38/00 ,  C07D241/08 ,  C07K1/04

Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.

公开(公告)号：US20180217086A1

公开(公告)日：2018-08-02

申请号：US15423067

申请日：2017-02-02

Applicant: Sandia Corporation ,  STC.UNM

Inventor： Fernando Henry Garzon ,  Lok-kun Tsui

IPC: G01N27/407 ,  G01N33/00 ,  G01N27/30

CPC classification number: G01N27/4074 ,  G01N33/0037 ,  G01N33/004 ,  G01N33/0047 ,  Y02A50/245

Abstract: A three-electrode mixed-potential electrochemical sensor coupled with an artificial neural network data analysis approach can extract concentrations from voltages and identify gas streams consisting of single and binary mixtures of NO2, NO, CO, and C3H8. By using the data from the sensors in biased and unbiased mode, single and binary mixtures can be identified with >98% accuracy identify all single and binary mixtures. While concentrations can be readily extracted from single test gas mixtures through a linear fit to the most sensitive electrode pair, binary mixture concentrations analyzed with an artificial neural network resulted in error distributions with a 95% peak accuracy in concentration with 80% of the data points having an accuracy at the 88% level. The sensor is suitable for control and monitoring of diesel and gasoline engines, turbines, steam power plants, and other combustion technologies.

公开(公告)号：US20180169009A1

公开(公告)日：2018-06-21

申请号：US15577572

申请日：2016-06-01

Applicant: Patrick JOHNSON ,  C. Jeffrey BRINKER ,  Eric CARNES ,  Graham TIMMINS ,  Pavan MUTTIL ,  STC.UNM

Inventor： Patrick Johnson ,  C. Jeffrey Brinker ,  Eric Carnes ,  Graham Timmins ,  Pavan Muttil

IPC: A61K9/00 ,  A61K9/16 ,  A61K47/54 ,  C08L23/22 ,  A61K9/12 ,  A61K9/127

CPC classification number: A61K9/0073 ,  A61K9/12 ,  A61K9/1271 ,  A61K9/1617 ,  A61K47/543 ,  C08L23/22

Abstract: This disclosure describes compositions, vaccine, and methods that involve a biocomposite material Generally, the biocomposite material includes a cell and a lipid-silica matrix at least partially encapsulating the cell. In some cases, the cell can be viable but not culturable (VBNC). In some cases, the lipid-silica matrix includes a dried sol and/or possesses ordered nanostructure.

公开(公告)号：US20180161298A1

公开(公告)日：2018-06-14

申请号：US15813438

申请日：2017-11-15

Applicant: STC.UNM

Inventor： Vojo P. Deretic ,  Michael Mandell

IPC: A61K31/201 ,  C12N9/00 ,  A61K38/53 ,  C12Q1/44 ,  C12Q1/61 ,  A61K45/06

CPC classification number: A61K31/201 ,  A61K38/53 ,  A61K45/06 ,  C12N9/93 ,  C12Q1/44 ,  C12Q1/61 ,  C12Y603/02 ,  G01N2333/92 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2500/20 ,  G01N2800/7028

Abstract: The present invention relates to the use of neutral lipids, including triglycerides, diglycerides and monoglycerides which may be used to increase neutral lipids (lipid stores and/or lipid droplets) and neutral lipid stores in order to regulate (in particular, induce) autophagy and treat and/or prevent autophagy related disease states and/or conditions. In one embodiment, the invention relates to the use of neutral lipids and/or TRIM proteins which may be used to regulate (in particular, induce) autophagy, target autophagic substrates and treat and/or prevent autophagic disease states and/or conditions.

公开(公告)号：US09989447B1

公开(公告)日：2018-06-05

申请号：US14795366

申请日：2015-07-09

Applicant: Sandia Corporation ,  STC.UNM

Inventor： Bryan J. Kaehr ,  Kristin Meyer ,  Jason L. Townson

IPC: C12N11/14 ,  G01N1/28

CPC classification number: G01N1/2806 ,  C08K3/36 ,  C12N11/14 ,  G01N1/2853

Abstract: The present invention relates to methods of transforming organic matter into organic-inorganic composites, inorganic replicas, or conductive replicas. Organic matter, such as biological cells and tissue and organs, can be converted into such composites and replicas using the methods described herein. In particular, such methods transform organic matter (into inorganic, organic-inorganic, or conductive constructs), while simultaneously preserving microscopic and/or macroscopic structural detail.

公开(公告)号：US09968698B2

公开(公告)日：2018-05-15

申请号：US14533612

申请日：2014-11-05

Applicant: STC.UNM

Inventor： David G. Whitten ,  Eric H. Hill ,  Harry C. Pappas

IPC: A61L2/18 ,  A01N41/04 ,  A01N33/12

CPC classification number: A61L2/18 ,  A01N33/12 ,  A01N41/04 ,  A01N25/30 ,  A01N41/02

Abstract: The invention relates to compositions including a charged oligo-phenylene ethynylene singlet-oxygen sensitizer and an oppositely-charged surfactant, which show an enhanced biocidal activity relative to a comparable concentration of the oligo-phenylene ethynylene without the oppositely-charged surfactant. The enhancement of biocidal activity is observed with an anionic oligo-phenylene ethynylene in the presence of a cationic surfactant such as TTAB, and with a cationic oligo-phenylene ethynylene in the presence of an anionic surfactant such as SDS.