公开(公告)号：US20150139963A1

公开(公告)日：2015-05-21

申请号：US14479385

申请日：2014-09-08

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Benjamin DEKEL ,  Orit HARARI-STEINBERG

IPC: A61K35/22 ,  C12N5/071

CPC classification number: A61K35/22 ,  C12N5/0686 ,  C12N5/0687 ,  C12N5/0696 ,  C12N15/85 ,  C12N2500/90 ,  C12N2501/06 ,  C12N2501/065 ,  C12N2501/415 ,  C12N2506/25

Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.

Abstract translation: 提供了分离的胎儿肾干细胞和祖细胞。 还提供了产生和使用这些分离的细胞群体的方法。

公开(公告)号：US20150119698A1

公开(公告)日：2015-04-30

申请号：US14584460

申请日：2014-12-29

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd. ,  Tel Hashomer Medical Research, Infrastructure And Service Ltd. ,  Drexel University

Inventor： Sara Eyal ,  Shlomo Magdassi ,  Emma Portnoy ,  Jacob Zauberman ,  Boris Polyak ,  Jacob Golenser ,  Yael Mardor ,  Dana Ekstein

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/055

CPC classification number: A61K49/0093 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4058 ,  A61K49/0017 ,  A61K49/0034

Abstract: Pharmaceutical composition including nanoparticles configured for enhanced phagocytosis by phagocytic cells and labeled with a near-infrared (NIR) fluorescent probe bound to the outer surface thereof, and uses thereof in the detection of activated immune cells in the central nervous system (CNS) of a subject.

Abstract translation: 药物组合物包括配置用于吞噬细胞增强的吞噬作用并用与其外表面结合的近红外（NIR）荧光探针）标记的纳米颗粒，以及其用于检测中枢神经系统（CNS）中活化的免疫细胞的用途 学科。

公开(公告)号：US20140270451A1

公开(公告)日：2014-09-18

申请号：US14352099

申请日：2012-10-18

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Leor Zach ,  David Guez ,  David Last ,  Dianne Daniels ,  Yael Mardor

IPC: G06K9/62 ,  G06T7/00

CPC classification number: G06K9/6202 ,  A61B5/0037 ,  A61B5/0042 ,  A61B5/055 ,  A61B2576/026 ,  G06T7/0012 ,  G16H50/50

Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.

Abstract translation: 公开了用于分析脑MRI的装置。 该装置包括用于在对比度施加后的预定时间间隔的开始和结束处接收第一和第二次MRI扫描的输入; 一种减法映射表，用于通过分析所述扫描来分析所述扫描以区分两个主要群体，其中来自组织的对比度清除比对比度积累慢的群体，以及快速群体，从而形成来自所述第一和所述第二次MRI扫描的减法映射 这个清除速度比积累快; 以及输出以提供所述两个主要群体的分布的指示，其中所述预定时间段至少为二十分钟。

公开(公告)号：US20140243230A1

公开(公告)日：2014-08-28

申请号：US14168981

申请日：2014-01-30

Applicant: Tel Hashomer Medical Research Infrastructure and Services Ltd. ,  Rosetta Genomics Ltd.

Inventor： Nitzan ROSENFELD ,  Yael Spector ,  Eddie Friedman ,  Zohar Dotan

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.

Abstract translation: 本发明提供了通过分析与其有关的特异性微小RNA和核酸分子的表达模式来分类肾肿瘤的方法。 根据microRNA表达框架进行分类可以优化治疗，并确定特异性治疗。

公开(公告)号：US20140023702A1

公开(公告)日：2014-01-23

申请号：US13945366

申请日：2013-07-18

Applicant: NIKKEN SOHONSHA CORPORATION ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Michael BELKIN ,  Aviv SHAISH ,  Dror HARATS ,  Ygal ROTENSTREICH

IPC: A61K36/05

CPC classification number: A61K36/05

Abstract: Provided is a method for improving day photopic vision and/or cone-derived visual field and visual function in a subject suffering from a retinal disease or trauma including administering to the subject a pharmaceutically effective amount of crude Dunaliella powder. Also provided is a method for improving night vision and/or rod derived visual field in a subject suffering from a retinal disease including administering to the subject a pharmaceutically effective amount of crude Dunaliella powder. A pharmaceutical composition for improving day vision and/or visual field in a subject suffering from a retinal disease including crude Dunaliella powder is also provided.

Abstract translation: 提供了一种在患有视网膜疾病或创伤的受试者中改善日视觉和/或锥形视野和视觉功能的方法，包括向受试者施用药学有效量的粗制杜氏盐藻粉。 还提供了一种在患有视网膜疾病的受试者中改善夜视和/或杆状视野的方法，包括向受试者施用药学有效量的粗制杜氏盐藻粉。 还提供了用于改善患有视网膜疾病，包括粗制杜氏盐藻粉末的受试者的日视力和/或视野的药物组合物。

公开(公告)号：US12097114B2

公开(公告)日：2024-09-24

申请号：US17932014

申请日：2022-09-14

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Ehud Raanani ,  Boris Orlov ,  Boaz Harari ,  Oded Meiri ,  Lichen Rozitsky

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2457 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2230/005 ,  A61F2230/0078 ,  A61F2250/006

Abstract: Apparatus and methods are described including placing a valve frame within a subject's heart. The valve frame includes a valve frame body that is configured to support the prosthetic valve within the native atrio-ventricular valve, and at least one arm that is configured to extend from a ventricular portion of the valve frame. The at least one arm is deployed among chords of the native atrio-ventricular valve. Subsequently, at least a portion of the valve frame is rotated in a direction in which an interior of the arm faces, such as to modify shapes of the native valve leaflets and the ventricular structures, by recruiting and deflecting at least a portion of the chords. The frame body of the valve frame is then radially expanded, such as to hold the native valve leaflets and the ventricular structures at least partially in the modified shapes. Other applications are also described.

公开(公告)号：US20240065829A1

公开(公告)日：2024-02-29

申请号：US18270852

申请日：2022-01-04

Applicant: Technion Research & Development Foundation Limited ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Shulamit LEVENBERG ,  Shira LANDAU ,  Shay DUVDEVANI

IPC: A61F2/18 ,  A61L27/38

CPC classification number: A61F2/18 ,  A61L27/3817 ,  A61F2002/183 ,  A61L2430/06

Abstract: An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.

公开(公告)号：US11911018B2

公开(公告)日：2024-02-27

申请号：US17271189

申请日：2019-08-29

Applicant: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.

Inventor： Ari Leshno

IPC: A61B17/02 ,  A61B90/00 ,  A61B17/00

CPC classification number: A61B17/0231 ,  A61B17/00491 ,  A61B90/06 ,  A61B90/08 ,  A61B2017/00858 ,  A61B2090/061 ,  A61B2090/0807

Abstract: Apparatus for performing an ocular surgery, the apparatus comprising: a support housing having a bottom configured to be positioned on the sclera of an eye during performance of an ocular surgery; a muscle hook holder connected to the support housing and configured to hold an ocular muscle hook so that the ocular muscle hook is translatable to elevate an ocular muscle away from the eye during performance of the surgery; and a set of graduation markings on the support housing useable to determine a distance that the ocular muscle hook is translated to elevate the ocular muscle.

公开(公告)号：US11820833B2

公开(公告)日：2023-11-21

申请号：US16306920

申请日：2017-06-02

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Nicola Maggio ,  Joab Chapman ,  Efrat Shavit Stein

IPC: C07K5/103 ,  C07K5/113 ,  C07K7/06 ,  C07K14/745 ,  C12N9/64 ,  C12N9/74 ,  A61K38/00 ,  A61P37/06 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07K5/1008 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07K5/1021 ,  C07K7/06 ,  C07K14/745 ,  C12N9/644 ,  C12N9/6429 ,  C12N9/6432 ,  C12N9/6437 ,  C12N9/6464 ,  A61K38/00

Abstract: An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US20230355727A1

公开(公告)日：2023-11-09

申请号：US18144968

申请日：2023-05-09

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Joab CHAPMAN ,  Efrat SHAVIT STEIN ,  Ygal ROTENSTREICH ,  Ifat SHER ROSENTHAL

IPC: A61P27/02 ,  A61K38/55 ,  A61K9/00

CPC classification number: A61K38/55 ,  A61K9/0048 ,  A61P27/02

Abstract: Ophthalmic formulations comprising a PAR1 antagonist and/or an agent that interferes with an interaction of PAR1 and a protease (e.g., thrombin), and an ophthalmically acceptable carrier, and uses thereof in treating or preventing retinal pathologies such as retinal degeneration, are provided. The agent can be, for example, a peptide conjugate represented by Formula I, as defined in the specification.