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    Scaffold comprising co-precipitated Collgen and glycosaminoglycan for inhibiting adhesion of body tissue layers
    134.
    发明授权
    Scaffold comprising co-precipitated Collgen and glycosaminoglycan for inhibiting adhesion of body tissue layers 有权
    支架包括共沉淀的Collgen和糖胺聚糖，用于抑制身体组织层的粘附

    公开(公告)号：US08431146B2

    公开(公告)日：2013-04-30

    申请号：US12725656

    申请日：2010-03-17

    申请人： Brendan A. Harley ,  Eric C. Soller ,  Eric Aiazian

    发明人： Brendan A. Harley ,  Eric C. Soller ,  Eric Aiazian

    IPC分类号： A61F2/00 ,  A61K38/43 ,  C12N11/02

    CPC分类号： A61K9/0024 ,  A61L31/129 ,  A61L31/146 ,  C08L89/06

    摘要： A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo.

    摘要翻译： 用于抑制人体组织层粘附的装置包括具有指定平均孔径，相对密度和降解半衰期的支架。 支架可以可操作地定位在装配组织层之间，例如在伤口部位处的邻近的粘附生成层，以便允许组织的再附着，而不形成纤维粘连。 本发明的支架装置通过促进收缩细胞迁移远离伤口部位预定的时间来抑制粘附形成。 本发明还涉及用于促进内部组织再生以及用于在体内提供和/或分配治疗和/或诊断剂的装置和方法。

    IMPLANTABLE MEDICAL DEVICES INCLUDING A HEAT-TREATED TANTALUM-ALLOY BODY HAVING A DRUG-ELUTING COATING THEREON, AND METHODS OF MAKING AND USING SAME
    135.
    发明申请
    IMPLANTABLE MEDICAL DEVICES INCLUDING A HEAT-TREATED TANTALUM-ALLOY BODY HAVING A DRUG-ELUTING COATING THEREON, AND METHODS OF MAKING AND USING SAME 审中-公开
    包括具有药物涂覆涂层的热处理的钛合金体的可植入医疗装置及其制造方法和使用方法

    公开(公告)号：US20130096666A1

    公开(公告)日：2013-04-18

    申请号：US13271511

    申请日：2011-10-12

    申请人： Rainer Bregulla ,  Randolf Von Oepen ,  Pamela A. Kramer-Brown ,  Austin M. Leach

    发明人： Rainer Bregulla ,  Randolf Von Oepen ,  Pamela A. Kramer-Brown ,  Austin M. Leach

    IPC分类号： A61F2/82 ,  C22F1/18 ,  B05D3/02 ,  B05D7/14

    CPC分类号： A61L31/088 ,  A61L31/022 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： The present disclosure is directed to a drug-eluting implantable medical devices that includes a tantalum-alloy body having a drug-eluting coating thereon for delivering a drug to treat, for example, restenosis. In an embodiment, an implantable medical device includes a body sized and configured to be implanted in a living subject. At least a portion of the body may comprise a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % (“wt %”) to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof. The body has a drug-eluting coating thereon.

    摘要翻译： 本公开涉及药物洗脱可植入医疗装置，其包括其上具有药物洗脱涂层的钽合金体，用于递送药物以治疗例如再狭窄。 在一个实施例中，可植入医疗装置包括尺寸和构造成植入生物体内的体。 身体的至少一部分可以包括钽合金。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金具有通过其热处理而改性的至少一种机械性能。 身体上有药物洗脱涂层。

    Stent coating for eluting medication
    138.
    发明授权
    Stent coating for eluting medication 有权
    用于洗脱药物的支架涂层

    公开(公告)号：US08367151B2

    公开(公告)日：2013-02-05

    申请号：US12755777

    申请日：2010-04-07

    申请人： Robert C. O'Brien ,  Christine A. Frysz

    发明人： Robert C. O'Brien ,  Christine A. Frysz

    IPC分类号： A61L33/00

    CPC分类号： A61L31/084 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/108 ,  Y10T29/49885

    摘要： A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.

    摘要翻译： 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架，每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层，同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除，暴露所有表面，并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性，而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。

    POROUS BIOABSORBABLE IMPLANT
    140.
    发明申请
    POROUS BIOABSORBABLE IMPLANT 审中-公开
    多孔可生物植入

    公开(公告)号：US20120277859A1

    公开(公告)日：2012-11-01

    申请号：US13545448

    申请日：2012-07-10

    申请人： Amit Govil ,  Michael L. Jones ,  Paul Lubock

    发明人： Amit Govil ,  Michael L. Jones ,  Paul Lubock

    IPC分类号： A61F2/12

    CPC分类号： A61L31/146 ,  A61F2/0077 ,  A61F2/02 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/148 ,  A61L31/18 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/44

    摘要： An implant for insertion into a breast lumpectomy cavity to serve as a guide for orienting a radiation source relative to the breast lumpectomy cavity, includes a body formed of a bioabsorbable material comprised of chitosan having a porosity sufficient to ensure tissue in-growth before significant bio-absorption of the implant, the body having exterior margins. An interior orientation marker is spaced inwardly from the exterior margins of the body to facilitate relative orientation between the implant and the radiation source.

    摘要翻译： 用于插入到乳房乳房切除腔中以用作用于相对于乳房乳房切除腔的定向辐射源的引导件的植入物包括由包含壳聚糖的生物可吸收材料形成的体，所述壳聚糖具有足以确保组织在生物显着生物 - 植入物的吸收，身体具有外部边缘。 内部取向标记物与身体的外部边缘向内间隔开，以促进植入物和辐射源之间的相对取向。