公开(公告)号：US20190022255A1

公开(公告)日：2019-01-24

申请号：US15798612

申请日：2017-10-31

Applicant: Yosef Koronyo ,  Maya Koronyo ,  Keith Black ,  Michal Schwartz ,  Daniel L. Farkas

Inventor： Yosef Koronyo ,  Maya Koronyo ,  Keith Black ,  Michal Schwartz ,  Daniel L. Farkas

IPC: A61K49/00

Abstract: The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

公开(公告)号：US20190018041A1

公开(公告)日：2019-01-17

申请号：US16120375

申请日：2018-09-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shahal ILANI ,  Sharon Pecker ,  Avishai Benyamini ,  Jonah Waissman ,  Assaf Hamo ,  Maayan Honig ,  Joseph Sulpizio ,  Lior Ella

IPC: G01Q60/16 ,  H01L29/06 ,  H01L29/10 ,  H01L29/76

Abstract: A method for use in construction of an electronic device and a transistor structure are presented. The method comprising: providing one or more nanotubes grown on a surface of a first substrate; providing a desired electrode arrangement fabricated on a surface of a second substrate. The electrode arrangement comprises at least two elevated source and drain electrodes and one or more gate electrodes located in between said elevated source and drain electrodes. The method also comprises bringing the electrode arrangement on the second substrate to close proximity with the first substrate such that surfaces of the first and second substrates face each other; scanning said first substrate with said electrode arrangement and determining contact of electrodes of the electrode arrangement with a nanotube located on the first substrate; and detaching said nanotube from the first substrate to provide a transistor structure comprising an isolated nanotube between the source and drain electrodes. The invention further provides systems comprising electronic devices and transistor structures of the invention. The invention further provides methods of use, the methods utilize electronic devices and transistor structures of the invention.

公开(公告)号：US10174343B2

公开(公告)日：2019-01-08

申请号：US15108389

申请日：2013-12-26

Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) ,  Yeda Research and Development Co. Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Itzhak Mizrahi ,  Naama Shterzer ,  Raphael Lamed ,  Inna Rozman Grinberg ,  Edward A. Bayer ,  Sarah Morais ,  Etai Landou

IPC: C12P19/14 ,  C12P7/14 ,  C12N1/22 ,  C12P39/00 ,  C12N9/42 ,  C12N9/24 ,  C12P7/06 ,  C12N9/04 ,  C12N9/88 ,  C12P7/10 ,  C12Q1/6888

Abstract: Lactic acid bacterial cultures, cell populations and articles of manufacture comprising same are disclosed for generating ethanol from lignocellulose.

公开(公告)号：US10125365B2

公开(公告)日：2018-11-13

申请号：US15111539

申请日：2015-02-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon Chen ,  Orna Issler

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N15/113 ,  C12N15/11 ,  C12Q1/6883 ,  C12N5/00

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US10072344B2

公开(公告)日：2018-09-11

申请号：US14409144

申请日：2013-06-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Scheiner ,  Jacob Karni ,  Raymond A George ,  Gabriel Seiden

IPC: C25B9/00 ,  C25B15/00 ,  B01J8/06 ,  B01J19/24 ,  C25B9/18 ,  F28F21/04 ,  F28D7/06 ,  F28D7/10 ,  F28D7/12

CPC classification number: C25B15/00 ,  B01J8/067 ,  B01J19/248 ,  B01J2219/00078 ,  B01J2219/00081 ,  B01J2219/00085 ,  B01J2219/00135 ,  B01J2219/00155 ,  B01J2219/00186 ,  C25B9/00 ,  C25B9/18 ,  F28D7/06 ,  F28D7/106 ,  F28D7/12 ,  F28F21/04

Abstract: A reactor is provided which comprises: a plurality of reaction units located within a reaction zone, each of the reaction units being adapted to enable carrying out a chemical reaction of one or more raw gases (e.g. at least one of CO2 and H20); ingress means to allow introduction of the one or more raw gases into the reaction zone and to allow distributing the incoming gas to the plurality of reaction units; egress means to allow exit of reaction products from the reaction zone; and a heating system. The reaction units extend essentially along a longitudinal axis of the reaction zone and are arranged in a spaced-apart relationship along a lateral axis of the reaction zone. The heating system comprises a plurality of heating sources extending along the reaction zone, thereby providing at least a part of the energy to carry out the reaction process within the reaction units.

公开(公告)号：US10072044B2

公开(公告)日：2018-09-11

申请号：US15180031

申请日：2016-06-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Schwartz-Eisenbach ,  Matityahu Fridkin ,  Michal Cardon-Yaakov

IPC: A61K9/00 ,  A61K38/00 ,  C07K7/06 ,  C07K7/64

CPC classification number: C07K7/06 ,  A61K9/0053 ,  A61K38/00 ,  C07K7/64

Abstract: The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions comprising them, for use in the treatment a disease or disorder presenting behavioral abnormalities associated with impairment of sensory gating function, depression or cognitive impairment, particularly schizophrenia and Alzheimer's disease.

公开(公告)号：US10066024B2

公开(公告)日：2018-09-04

申请号：US13882192

申请日：2011-10-27

Applicant: Irit Sagi ,  Netta Sela-Paswell ,  Moran Grossman

Inventor： Irit Sagi ,  Netta Sela-Paswell ,  Moran Grossman

IPC: C07K16/40 ,  C07K16/44

Abstract: A method of generating an antibody which inhibits a metalloenzyme is disclosed. The method comprises immunizing a subject with: (i) a synthetic zinc mimicry compound having structural and electronic properties similar to a catalytic domain of the metalloenzyme; and (ii) the metalloenzyme, Antibodies generated by this method are also disclosed as well as uses thereof.

公开(公告)号：US10053712B2

公开(公告)日：2018-08-21

申请号：US15101097

申请日：2014-12-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Arren Bar-Even ,  Ron Milo ,  Elad Noor ,  Lior Zelcbuch

IPC: C12P7/40 ,  C12N1/20 ,  C12N9/10 ,  C12N15/52 ,  C12P5/00 ,  C12P5/02 ,  C12P7/06 ,  C12P7/16 ,  C12P7/26 ,  C12P7/64

CPC classification number: C12P7/40 ,  C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12P5/007 ,  C12P5/023 ,  C12P5/026 ,  C12P7/06 ,  C12P7/16 ,  C12P7/26 ,  C12P7/649 ,  C12Y203/01054 ,  Y02E50/17 ,  Y02E50/343

Abstract: An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.Uses of the microorganism and products comprising same are also disclosed.

公开(公告)号：US20180223302A1

公开(公告)日：2018-08-09

申请号：US15737558

申请日：2016-06-22

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Yeda Research and Development Co. Ltd., at the Weizmann Institute of Science

Inventor： Arren BAR-EVEN ,  Tobias ERB ,  Steffen LINDNER ,  Philippe MARLIERE ,  Dan S. TAWFIK

IPC: C12N15/82

CPC classification number: C12N15/8269 ,  C12N15/8261 ,  Y02A40/146

Abstract: The present invention relates to an organism, a tissue, a cell or an organelle expressing enzymes which allow the conversion of 2-phosphoglycolate (2-PG; also known as glycolate 2-phosphate) into an intermediate compound of the Calvin-Benson-Bassham Cycle (CBBC) without releasing CO2. The organism, tissue, cell or organelle of the invention may be genetically engineered, transgenic and/or transplastomic so as to express at least one enzyme which is involved in this conversion. The present invention further relates to an organism, tissue, cell or organelle which comprises/expresses at least one enzyme which is involved in this conversion. The present invention further relates to a method for producing an organism, tissue, cell or organelle of the invention. The present invention further relates to a method of enzymatically converting 2-PG into an intermediate compound of the CBBC without releasing CO2. The present invention further relates to the use of an organism, tissue, cell or organelle of the invention for enzymatically converting 2-PG into an intermediate compound of the CBBC without releasing CO2.

公开(公告)号：US10040868B2

公开(公告)日：2018-08-07

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Moran Grossman ,  Nir Ben-Chetrit

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/40 ,  A61K45/06 ,  A61K33/24

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.