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公开(公告)号：US20180172687A1
公开(公告)日：2018-06-21
申请号：US15897040
申请日：2018-02-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ravi Kaul , Weiming Zheng , Roger Walker
IPC: G01N33/576 , G01N33/543
CPC classification number: G01N33/5761 , G01N33/54326
Abstract: Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.
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公开(公告)号：US20180171387A1
公开(公告)日：2018-06-21
申请号：US15717103
申请日：2017-09-27
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
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公开(公告)号：US09971138B2
公开(公告)日：2018-05-15
申请号：US14262559
申请日：2014-04-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael Griffin , Daniel Yue Man Chu , Tom McCollum
CPC classification number: G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
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公开(公告)号：US20180085735A1
公开(公告)日：2018-03-29
申请号：US15714368
申请日：2017-09-25
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Jiali Liao , Christopher Belisle
IPC: B01J20/24 , C07K1/22 , C07K1/36 , C07K14/435 , C07K16/00 , B01J20/04 , B01J20/28 , B01J20/285 , B01D15/38
Abstract: Polymer-filled ceramic apatites and their uses are provided.
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公开(公告)号：US09927439B2
公开(公告)日：2018-03-27
申请号：US14261525
申请日：2014-04-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ravi Kaul , Weiming Zheng , Roger Walker
IPC: C12Q1/68 , C12Q1/70 , A61K39/00 , A61K39/29 , C07K14/005 , G01N33/576 , G01N33/543
CPC classification number: G01N33/5761 , G01N33/54326
Abstract: Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.
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Patent Agency Ranking
公开(公告)号：US09896717B2
公开(公告)日：2018-02-20
申请号：US14272370
申请日：2014-05-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Shawn Hodges , Nick Heredia , Jonathan Petersen
CPC classification number: C12Q1/6804 , C12Q2537/159 , C12Q2561/101 , C12Q2563/143 , C12Q2563/149
Abstract: The present invention provides methods of detecting an antigen in a sample comprising contacting the sample with affinity agents to form an antigen-affinity agent-label complex, separating the antigen-affinity agent-label complex from uncomplexed components, partitioning label from the separated sample into multiple partitions, and detecting the presence of the label in one or more partitions. Compositions and kits for detecting an antigen in a sample are also provided.
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公开(公告)号：US09895693B2
公开(公告)日：2018-02-20
申请号：US14642487
申请日：2015-03-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Clayton T. McKee , William Strong
IPC: G01N33/543 , B01L3/00 , G01N27/447 , C12Q1/68
CPC classification number: B01L3/502738 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/047 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/065 , C12Q1/6806 , G01N27/44717 , G01N27/44739 , G01N33/54366
Abstract: Devices, systems, methods, and kits are provided for performing separation, immobilization, blotting, and/or detection of analytes from biological samples. In some embodiments, the devices are constructed from two solid substrates with surfaces in contact. The devices include a plurality of channels formed from indentations in these surfaces. The indentations can be aligned with each other across the interface between the substrates, and realigned by shifting or sliding one substrate relative to the other. In some embodiments, the devices are constructed from three layers of a solid substrate. A separation channel in the middle layer of the device is first used for analyte separation. The middle layer can then be slid relative the top and/or bottom layer, thereby aligning the separation channel with a blotting membrane. Analytes can then be transferred to the membrane using electrodes in the top and bottom layers.
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公开(公告)号：US09885862B2
公开(公告)日：2018-02-06
申请号：US14267762
申请日：2014-05-01
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Frank Hsiung , Kelly Kroeger , Robert Archer , Veronika Kortisova , Teresa Rubio
CPC classification number: G02B21/368 , G02B21/241 , G02B21/365
Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus.
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公开(公告)号：US20180011093A1
公开(公告)日：2018-01-11
申请号：US15710334
申请日：2017-09-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： David King , William F. Link , Renato del Rosario , Michael Leos
IPC: G01N33/569 , C12N9/10 , C12N11/14 , G01N33/543
CPC classification number: G01N33/543 , C12N9/1044 , C12N11/14 , C12Y203/02013 , G01N33/54393 , G01N33/56988
Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.
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公开(公告)号：US20180010175A1
公开(公告)日：2018-01-11
申请号：US15711215
申请日：2017-09-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Man CHENG
CPC classification number: C12Q1/6841 , C12P19/34 , C12Q1/682 , C12Q1/6844 , C12Q2545/114 , C12Q2600/158 , C12Q2521/119 , C12Q2525/307 , C12Q2531/125 , C12Q2537/1376 , C12Q2543/101
Abstract: Methods and compositions for in situ detection of circular RNA in a tissue sample are provided.
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