公开(公告)号：US20180215701A1

公开(公告)日：2018-08-02

申请号：US15388770

申请日：2016-12-22

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Bruce Edward Blough ,  Philip Abraham

IPC: C07C225/16 ,  C07C211/27 ,  C07C225/18 ,  C07C211/35 ,  C07C211/29

CPC classification number: C07C225/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C225/18 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

Abstract: The invention provides bupropion analogue compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.

公开(公告)号：US09988664B2

公开(公告)日：2018-06-05

申请号：US14950813

申请日：2015-11-24

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： David Samuel Ensor ,  Howard Jerome Walls ,  Karin K Foarde

IPC: C12Q1/00 ,  C12Q1/24 ,  B82Y15/00 ,  G01N1/22

CPC classification number: C12Q1/24 ,  B01D2239/025 ,  B01D2239/0604 ,  B82Y15/00 ,  G01N1/2205 ,  G01N1/2208 ,  G01N1/2214 ,  G01N33/497 ,  G01N2001/2223

Abstract: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and configured to provide a viability enhancing material to the collected bioparticles to maintain viability of the bioparticles collected by the fiber mat. The aerosol collection system includes an aerosol pumping device configured to entrain particles in an gas stream, an aerosol saturation device configured to saturate the particles in the gas stream with a biocompatible liquid, and an aerosol collection medium downstream from the aerosol saturation device and including a plurality of fibers formed into a fiber mat for collection of the saturated aerosol particles.

公开(公告)号：US20180043328A1

公开(公告)日：2018-02-15

申请号：US15788573

申请日：2017-10-19

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Jian-Ping Shen ,  Luke James Ivor Coleman ,  Marty Alan Lail ,  Raghubir Prasad Gupta ,  Brian Scott Turk

IPC: B01J20/04 ,  B01D53/62 ,  B01J20/34 ,  B01D53/96 ,  B01J20/28 ,  B01J20/30 ,  B01D53/02 ,  B01D53/82

CPC classification number: B01J20/043 ,  B01D53/02 ,  B01D53/0462 ,  B01D53/0476 ,  B01D53/62 ,  B01D53/82 ,  B01D53/96 ,  B01D2251/304 ,  B01D2251/402 ,  B01D2251/602 ,  B01D2251/606 ,  B01D2253/1124 ,  B01D2257/504 ,  B01D2258/01 ,  B01D2258/0241 ,  B01D2258/025 ,  B01D2258/0283 ,  B01J20/04 ,  B01J20/041 ,  B01J20/28011 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/3433 ,  B01J20/3483 ,  B01J20/3491 ,  B01J2220/42 ,  C10K1/005 ,  C10K1/26 ,  Y02C10/04 ,  Y02C10/08 ,  Y02C20/20 ,  Y02P20/152

Abstract: A mixed salt composition adapted for use as a sorbent for carbon dioxide removal from a gaseous stream is provided, the composition being in solid form and including magnesium oxide, an alkali metal carbonate, and an alkali metal nitrate, wherein the composition has a molar excess of magnesium characterized by a Mg:X atomic ratio of at least about 3:1, wherein X is the alkali metal. A process for preparing the mixed salt is also provided, the process including mixing a magnesium salt with a solution comprising alkali metal ions, carbonate ions, and nitrate ions to form a slurry or colloid including a solid mixed salt including magnesium carbonate; separating the solid mixed salt from the slurry or colloid to form a wet cake; drying the wet cake to form a dry cake including the solid mixed salt; and calcining the dry cake to form a mixed salt sorbent.

公开(公告)号：US20170241893A1

公开(公告)日：2017-08-24

申请号：US15048199

申请日：2016-02-19

Applicant: Research Triangle Institute

Inventor： Howard Jerome Walls ,  Anthony Clint Clayton ,  Randall J. Newsome ,  Paul G. Hoertz

IPC: G01N15/14 ,  G01N21/53 ,  G01N21/64

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G01N21/6486 ,  G01N2015/0046 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2021/4721 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A particle detector includes a housing, a light source, and a photo-responsive material. The housing includes a sample inlet and a sample outlet, and encloses a detection cavity. The light source directs irradiating light to particles of a sample fluid flowing in the detection cavity. The photo-responsive material faces the detection cavity, and receives measurement light propagating from the particles in a plurality of measurement light paths angled relative to a longitudinal axis. The particle detector may be utilized to measure scattered light and/or light emitted due to autofluorescence. Fluids sampled may include aerosols, bio-aerosols, and liquids.

公开(公告)号：US09709541B2

公开(公告)日：2017-07-18

申请号：US15060573

申请日：2016-03-03

Applicant: Research Triangle Institute

Inventor： Charles E. Rodes ,  J. Randall Newsome

IPC: G01N33/00 ,  G01N1/22 ,  G01N15/02 ,  G01N21/51 ,  G01N21/53

CPC classification number: G01N33/0027 ,  G01N1/2273 ,  G01N15/0255 ,  G01N21/51 ,  G01N21/53 ,  G01N33/0016

Abstract: A gas processing device includes a sample inlet defining a gas flow path into a housing, and a pump and a noise dampening device disposed in the housing. The noise dampening device includes an inlet chamber, an outlet chamber, and an elastomeric membrane interposed between and fluidly isolating the inlet chamber and the outlet chamber. The inlet chamber is interposed between the sample inlet and the pump inlet, and the outlet chamber communicates with the pump outlet.

公开(公告)号：US20170197198A1

公开(公告)日：2017-07-13

申请号：US15326214

申请日：2015-07-14

Applicant: Research Triangle Institute

Inventor： Mustapha Soukri ,  Luke Coleman ,  Marty Lail

IPC: B01J20/26 ,  B01D53/02 ,  C08G73/02 ,  B01J20/10 ,  B01J20/30

CPC classification number: B01J20/262 ,  B01D53/02 ,  B01D2253/106 ,  B01D2253/202 ,  B01D2253/25 ,  B01D2256/22 ,  B01D2257/504 ,  B01D2258/0283 ,  B01J20/103 ,  B01J20/3085 ,  C08G73/0206 ,  C08G73/0213 ,  Y02C10/08

Abstract: Solid sorbent materials have been prepared by combining polyethyleneimine (PEI) with silica precursors. The solid sorbent materials can be used, for example, for acid gas separation, gas purification, and water purification applications. Advantageously, such materials can be water stable and the capacity of such solid sorbent materials does not diminish substantially after repeated use and regeneration.

公开(公告)号：US09622995B2

公开(公告)日：2017-04-18

申请号：US14711355

申请日：2015-05-13

Applicant: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  DUKE UNIVERSITY ,  RESEARCH TRIANGLE INSTITUTE

Inventor： Mary E. Abood ,  Pingwei Zhao ,  Lawrence S. Barak ,  Herbert H. Seltzman

IPC: A61K31/194 ,  A61K31/191

CPC classification number: A61K31/194 ,  A61K31/191

Abstract: Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

公开(公告)号：US20170042643A1

公开(公告)日：2017-02-16

申请号：US15292289

申请日：2016-10-13

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Jeffrey Robert Piascik ,  Brian R. Stoner

IPC: A61C8/00 ,  A61C5/04 ,  A61C5/10 ,  A61C7/14 ,  A61C13/00 ,  B05D3/14 ,  B05D3/10 ,  B05D3/04 ,  A61K6/02 ,  A61K6/08 ,  A61L27/50 ,  A61L27/14 ,  A61L27/10 ,  A61L27/06 ,  A61C5/02

CPC classification number: A61C8/0015 ,  A61C5/30 ,  A61C5/40 ,  A61C5/50 ,  A61C5/70 ,  A61C5/77 ,  A61C7/00 ,  A61C7/14 ,  A61C8/00 ,  A61C13/0006 ,  A61C13/225 ,  A61K6/0029 ,  A61K6/0205 ,  A61K6/0225 ,  A61K6/0235 ,  A61K6/024 ,  A61K6/04 ,  A61K6/0687 ,  A61K6/08 ,  A61L27/06 ,  A61L27/10 ,  A61L27/105 ,  A61L27/14 ,  A61L27/50 ,  A61L2400/18 ,  A61L2430/12 ,  B05D3/0433 ,  B05D3/104 ,  B05D3/141 ,  C08L83/16

Abstract: A fluoride treated medical implant, such as a dental component, is provided, the medical implant comprising fluorinated metal oxide on the substrate surface. A method for the preparation of such treated implants is also provided, the method involving exposure of the medical implant to a fluorine-containing reagent. A dental structure is also provided, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a silane coupling agent, a dental cement, and a second dental component having a surface bonded to the dental cement. An additional dental structure, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a dental cement, and a second dental component having a surface bonded to the dental cement is also provided.

Abstract translation: 提供氟化物处理的医疗植入物，例如牙科部件，医疗植入物在基底表面上包括氟化金属氧化物。 还提供了用于制备这种处理的植入物的方法，该方法涉及将医用植入物暴露于含氟试剂。 还提供了一种牙科结构，其包括其表面上包含氟化金属氧化物层的第一牙科成分，硅烷偶联剂，牙科粘合剂和具有粘合到牙科粘固剂的表面的第二牙齿部件。 还提供另外的牙科结构，其包括在其表面上包含氟化金属氧化物层的第一牙科部件，牙科牙科粘合剂和具有粘合到牙科粘固剂的表面的第二牙科部件。

公开(公告)号：US09527823B2

公开(公告)日：2016-12-27

申请号：US14537124

申请日：2014-11-10

Applicant: Research Triangle Institute ,  Dignity Health ,  Virginia Commonwealth University

Inventor： Frank Ivy Carroll ,  Bruce E. Blough ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Ana Zamfira Muresan ,  M. Imad Damaj ,  Ronald J. Lukas

IPC: C07D265/32 ,  A61K31/5375

CPC classification number: C07D265/32 ,  A61K31/5375

Abstract: The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

Abstract translation: 本发明提供了能够抑制一种或多种单胺再摄取和/或在烟碱乙酰胆碱受体上作为拮抗剂的羟基安非他丁类似物。 所述化合物可以选择性地结合一种或多种单胺转运蛋白，包括用于多巴胺，去甲肾上腺素和5-羟色胺的单胺转运蛋白和/或可以选择性地结合一种或多种烟碱型乙酰胆碱受体亚型。 这些化合物可用于治疗对单胺水平的修饰和/或烟碱乙酰胆碱受体的拮抗作用有反应的病症，包括药物依赖性，抑郁症和肥胖症。

公开(公告)号：US09518080B2

公开(公告)日：2016-12-13

申请号：US13974633

申请日：2013-08-23

Applicant: RESEARCH TRIANGLE INSTITUTE ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Scott P Runyon ,  Michael Rogawski ,  Edgar Cook ,  John Kepler ,  Hernan Navarro ,  Rafal Kaminski ,  Matthew Orr

IPC: A61K31/56 ,  C07J41/00 ,  C07J7/00 ,  C07J31/00

CPC classification number: C07J41/0005 ,  C07J7/00 ,  C07J31/003

Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.