公开(公告)号：US10060907B2

公开(公告)日：2018-08-28

申请号：US15438859

申请日：2015-08-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Peter Gebauer ,  Dieter Heindl ,  Carina Horn ,  Maksim Fomin

IPC: G01N33/52 ,  G01N33/50 ,  C07D241/42 ,  C07D403/06

CPC classification number: G01N33/52 ,  C07D241/40 ,  C07D241/42 ,  C07D401/06 ,  C07D403/06 ,  G01N33/5005

Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine-isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.

公开(公告)号：US20180224476A1

公开(公告)日：2018-08-09

申请号：US15875215

申请日：2018-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Armin Birrer ,  Andreas Drechsler ,  Rik Harbers

IPC: G01N35/10 ,  G01N21/51 ,  G06T7/60

CPC classification number: G01N35/10 ,  B65G54/02 ,  G01N21/51 ,  G01N35/00732 ,  G01N35/04 ,  G01N2035/00801 ,  G01N2035/00821 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0493 ,  G06T7/0012 ,  G06T7/60

Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.

公开(公告)号：US20180217174A1

公开(公告)日：2018-08-02

申请号：US15863028

申请日：2018-01-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michal Malinowski

IPC: G01N35/04 ,  G01N35/00 ,  G01R19/25

CPC classification number: G01N35/04 ,  B65G54/02 ,  G01N35/00584 ,  G01N2035/00445 ,  G01N2035/0475 ,  G01N2035/0477 ,  G01R19/2513

Abstract: A laboratory sample distribution system is presented. The system comprises carriers to carry sample containers. Each carrier comprises a magnetically active device. The system comprises a transport plane to support the carriers and electro-magnetic actuators stationary arranged below the transport plane. The actuators move the carriers on top of the transport plane by applying a magnetic force to the carriers. The system comprises a control device to control the movement of the carriers on top of the transport plane by driving the actuators such that the carriers move along corresponding transport paths simultaneously and independently from one another and a sensor to measure supply currents and/or supply voltages. The actuators are supplied with electrical energy based on the supply currents and/or the supply voltages. The system comprises a monitoring device coupled to the sensor. The monitoring device monitors the actuators temperature based on the measured supply currents and/or supply voltages.

公开(公告)号：US20180188280A1

公开(公告)日：2018-07-05

申请号：US15840805

申请日：2017-12-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michal Malinowski

IPC: G01N35/10 ,  G01N35/04 ,  G01B7/00 ,  H01F7/02

CPC classification number: G01N35/1081 ,  G01B7/003 ,  G01N35/04 ,  G01N2035/00425 ,  G01N2035/0406 ,  G01N2035/0422 ,  G01N2035/0477 ,  G01N2035/0491 ,  G01N2035/0493 ,  H01F7/0205

Abstract: A laboratory sample distribution system is presented. The system comprises a number of sample container carriers, a transport plane, a number of electro-magnetic actuators, a number of position sensors and a position determination unit. The position sensors and the position determination unit enable improved sample container carrier position detection on the transport plane. A laboratory automation system comprising such a laboratory sample distribution system is also presented.

公开(公告)号：US10012666B2

公开(公告)日：2018-07-03

申请号：US14665397

申请日：2015-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christian Riether

IPC: G01N35/10 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC classification number: G01N35/1081 ,  G01N35/0092 ,  G01N35/02 ,  G01N2035/00445 ,  G01N2035/0406 ,  G01N2035/0462 ,  G01N2035/0477

Abstract: A sample distribution system having a transport surface on which sample container carriers can be moved is presented. The sample distribution system has ambient-condition influencing device in order to influence ambient conditions over a sub-region of the transport surface in such a way that samples can be kept there for a certain time without impairment.

公开(公告)号：US09999398B2

公开(公告)日：2018-06-19

申请号：US14017776

申请日：2013-09-04

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christen A. Rees ,  Sheldon A. White

IPC: A61B5/00 ,  A61M5/172 ,  A61B5/145 ,  H04L12/815 ,  G06F19/00 ,  H04L29/08

CPC classification number: A61B5/74 ,  A61B5/14532 ,  A61M5/1723 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3468 ,  G16H20/10 ,  G16H20/17 ,  H04L47/22 ,  H04L67/12 ,  H04L67/322

Abstract: A computer implemented method for transmitting messages generated by a continuous glucose monitor (CGM), the method comprising: generating a first message at the CGM at a first time, the first message being related to blood glucose measuring; generating a second message at the CGM at a second time, the second time being after the first time, the second message being related to blood glucose measuring; determining an elapsed time since a transmitter of the CGM has transmitted data; determining whether the elapsed time is greater than a threshold; determining whether the second message is to be transmitted before the first message, in response to the elapsed time being greater than the threshold; and transmitting data corresponding with the second message before transmitting data corresponding with the first message to a diabetes management device, in response to determining that the second message is to be transmitted before the first message.

公开(公告)号：US20180156832A1

公开(公告)日：2018-06-07

申请号：US15883458

申请日：2018-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marco Bucher ,  Gottlieb Schacher

IPC: G01N35/02 ,  G01N35/04 ,  B65G47/82 ,  B65G25/08

CPC classification number: G01N35/026 ,  B65G25/08 ,  B65G47/82 ,  B65G2201/0235 ,  G01N35/04 ,  G01N2035/0415 ,  G01N2035/0475

Abstract: A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. The second rail moves along the first rail and comprising a transfer head movable along the second rail. The transfer head comprises a control pin to be coupled with one of: an input pusher, translatable in the second direction, for transferring a rack from a carrier to a sampling area of an analyzer; an output pusher for transferring a rack from the sampling area to a carrier; a rack for transferring the rack between different carriers and/or between different positions of the same carrier. An in-vitro diagnostic instrument comprises an analyzer for carrying out tests on biological samples, a sample unit for inputting/outputting racks, a sampling area for withdrawing samples from tubes, and a transfer device.

公开(公告)号：US09989547B2

公开(公告)日：2018-06-05

申请号：US15405432

申请日：2017-01-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Pedain

IPC: B65G54/02 ,  G01N35/04

CPC classification number: G01N35/04 ,  B65G54/02 ,  B65G2201/0261 ,  G01N2035/0477

Abstract: A laboratory sample distribution system is presented. The system comprises sample container carriers carrying a sample container and comprising a magnetically active device. The system also comprises a transport plane supporting the sample container carriers and comprises drive modules comprising first line shaped conductors extending in a first direction and arranged parallel to each other and second line shaped conductors extending in a second direction and arranged parallel to each other. The system comprises a driver electrically connected to each of the first and second conductors of the drive modules. The driver selectively applies a drive current and/or voltage to the first and second conductors such that a conductor current results in the conductors driven by the drive current and/or voltage. The conductor current selectively causes a drive force to the sample container carriers such that the sample container carriers move along individual transport paths on the transport plane.

公开(公告)号：US09988358B2

公开(公告)日：2018-06-05

申请号：US15290440

申请日：2016-10-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Christine Nortmeyer ,  Peter Gebauer ,  Stacy H. Duvall ,  Klaus Andreas Bauer-Espindola

IPC: C07D241/46 ,  C12Q1/26

CPC classification number: C07D241/46 ,  C12Q1/26

Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.

公开(公告)号：US09962699B2

公开(公告)日：2018-05-08

申请号：US15352672

申请日：2016-11-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Sascha Lutz ,  Juergen Spinke

IPC: B01L3/00 ,  G01N1/38 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/50273 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  B01L2400/0694 ,  G01N1/38 ,  G01N35/00069 ,  G01N35/1016 ,  G01N2035/00247 ,  G01N2035/00257 ,  G01N2035/1032 ,  G01N2035/1034

Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.