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151.发明申请公开(公告)号：US20180256564A1
公开(公告)日：2018-09-13
申请号：US15978499
申请日：2018-05-14
Applicant: H. LEEMOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Inventor： SAID M. SEBTI , NICHOLAS J. LAWRENCE , JAMES TURKSON
IPC: A61K31/495 , A61K33/24 , G01N33/50 , C07D295/088
CPC classification number: A61K31/495 , A61K33/24 , C07D295/088 , G01N33/5091
Abstract: The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.
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152.发明授权公开(公告)号：US10070651B2
公开(公告)日：2018-09-11
申请号：US15292523
申请日：2016-10-13
Inventor： Swadeshmukul Santra , Joshua J. Bazata
IPC: C09C1/30 , B82Y30/00 , B22F9/24 , B22F1/02 , B22F1/00 , A01N25/28 , A01N59/16 , C09D5/14 , C01B33/18
CPC classification number: A01N59/16 , A01N25/28 , B22F1/0018 , B22F1/0044 , B22F1/02 , B22F9/24 , B82Y30/00 , C01B33/18 , C09C1/3054 , C09D5/14
Abstract: The present invention relates to, inter alia, a composition, a nanocomposite material, and a method for preparing the nanocomposite material. The nanocomposite material includes: a dielectric-silver nanocomposite material, the dielectric-silver nanocomposite material including a silver nanoparticle having a silver ion, and a dielectric material encapsulating the silver nanoparticle, where the silver ion chelates with a matrix of the dielectric material, and a surface plasmon band absorption of the dielectric-silver nanocomposite material lies outside a range of a visible region.
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公开(公告)号：US20180231550A1
公开(公告)日：2018-08-16
申请号：US15751638
申请日：2016-08-11
Inventor： Bradley J. WILLENBERG , Sudipta SEAL
IPC: G01N33/569 , G01N33/58 , G01N33/577 , A01M1/02
CPC classification number: G01N33/56983 , A01M1/02 , A01M1/023 , A01M1/026 , A01M1/106 , G01N33/569 , G01N33/577 , G01N33/585 , G01N2333/185 , G01N2333/43591 , Y02A50/371 , Y02A50/51 , Y02A50/53 , Y02A50/57 , Y02A50/58
Abstract: Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.
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公开(公告)号：US09968599B2
公开(公告)日：2018-05-15
申请号：US14947786
申请日：2015-11-20
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Inventor： Said M. Sebti , Nicholas J. Lawrence , James Turkson
IPC: A61K31/495 , C07D295/088 , G01N33/50 , A61K33/24
CPC classification number: A61K31/495 , A61K33/24 , C07D295/088 , G01N33/5091
Abstract: The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.
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公开(公告)号：US09963805B2
公开(公告)日：2018-05-08
申请号：US15243423
申请日：2016-08-22
Inventor： Donald T. Haynie , Lei Zhai
CPC classification number: D01F6/68 , C08G69/10 , C08L77/04 , D01D5/0007 , D01D5/003 , D01D5/0038 , D04H1/728 , D04H3/016 , Y10T428/298
Abstract: Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
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Patent Agency Ranking
公开(公告)号：US09950007B2
公开(公告)日：2018-04-24
申请号：US14733185
申请日：2015-06-08
Inventor： William T. Self , Ella Bossy-Wetzel , Sudipta Seal , Janet Dowding
IPC: A61K33/24
CPC classification number: A61K33/24
Abstract: A method of treating a subject with elevated levels of peroxynitrite includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject.
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公开(公告)号：US20180092913A1
公开(公告)日：2018-04-05
申请号：US15726533
申请日：2017-10-06
Inventor： Kiminobu SUGAYA , Angel ALVAREZ
IPC: A61K31/497
CPC classification number: A61K31/497
Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.
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公开(公告)号：US09908808B1
公开(公告)日：2018-03-06
申请号：US15240975
申请日：2016-08-18
Abstract: Ternary chalcogenide glass materials containing germanium can display enhanced properties compared to corresponding binary chalcogenide glass materials lacking germanium. For instance, ternary chalcogenide glass materials containing germanium, arsenic and selenium can exhibit improved Vickers micro-hardness values and other enhanced mechanical properties while still maintaining small changes in refractive index as function of temperature. Such ternary glass materials can have a formula of (AsySez)[(100-x)·0.01]Gex, in which x ranges between about 1 and 5, y ranges between about 30 and 40, z ranges between about 60 and 70, and y+z=100. Methods for producing the ternary glass materials can include blending arsenic, selenium, and germanium as a melt, and cooling the melt to form the ternary glass material.
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公开(公告)号：US20180019572A1
公开(公告)日：2018-01-18
申请号：US15648260
申请日：2017-07-12
Inventor： DENNIS G. DEPPE
CPC classification number: H01S5/18308 , H01S5/183 , H01S5/18322 , H01S5/18327 , H01S5/18358 , H01S5/2018 , H01S5/2054 , H01S5/2059 , H01S5/3013 , H01S5/305 , H01S5/3054 , H01S5/3201 , H01S5/323 , H01S2301/166
Abstract: A semiconductor vertical light source includes an upper mirror and a lower mirror. An active region is between the upper and lower mirror. The light source includes an inner mode confinement region and outer current blocking region. The outer current blocking region includes a common epitaxial layer that includes an epitaxially regrown interface which is between the active region and upper mirror, and a conducting channel including acceptors is in the inner mode confinement region. The current blocking region includes a first impurity doped region with donors between the epitaxially regrown interface and active region, and a second impurity doped region with acceptors is between the first doped region and lower mirror. The outer current blocking region provides a PNPN current blocking region that includes the upper mirror or a p-type layer, first doped region, second doped region, and lower mirror or an n-type layer.
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公开(公告)号：US20170334728A1
公开(公告)日：2017-11-23
申请号：US15659386
申请日：2017-07-25
Inventor： Richard Blair
IPC: C01B32/198 , C01B32/19 , C01B32/194
CPC classification number: C01B32/198 , C01B32/182 , C01B32/19 , C01B32/192 , C01B32/194 , C01B32/23
Abstract: Existing methods of producing high quality graphene/graphite oxides are generally accomplished by exfoliating graphite into flakes and oxidizing the graphite flakes with strong oxidizers under extreme conditions and require careful purification. The oxidizers are typically strong acids used in high concentrations at elevated temperatures requiring complicated purification processes to yield oxidized graphene/sheets. The existing processes can cost up to $12,000/gram. This invention uses a mild oxidant combined with mechanical processing where the sole products are oxidized graphite/graphene and water without the need for further purification.
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