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    MODIFIED LISTERIA BACTERIA AND USES THEREOF
    161.
    发明申请
    MODIFIED LISTERIA BACTERIA AND USES THEREOF 有权
    改良的LISTERIA细菌及其用途

    公开(公告)号：US20150368654A1

    公开(公告)日：2015-12-24

    申请号：US14706178

    申请日：2015-05-07

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Anat AFRIAT HERSKOVITS ,  Millie KAPLAN ZEEVI

    IPC: C12N15/74 ,  A61K39/00

    CPC classification number: C12N15/74 ,  A61K39/0208 ,  A61K2039/52 ,  A61K2039/522

    Abstract: A Listeria bacterium is disclosed which comprises a first mutation in the multidrug resistance transporter M (MdrM) gene which causes a decrease in interferon-β production in macrophages as compared to wild-type Listeria bacterium and a second mutation in the multidrug resistance transporter T (MdrT) gene which causes a decrease in interferon-β production in macrophages as compared to the wild-type Listeria bacterium.

    Abstract translation: 公开了一种利斯特氏菌属细菌，其包含多药耐药转运蛋白M（MdrM）基因中的第一个突变，其导致干扰素-bgr的减少; 与野生型利斯特氏菌相比，在巨噬细胞中的产生和多药耐药转运蛋白T（MdrT）基因中的第二个突变导致干扰素-bgr的减少; 与野生型利斯特氏菌相比，在巨噬细胞中的产生。

    COMBINATION TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    162.
    发明申请
    COMBINATION TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) 审中-公开
    综合性脊柱侧凸性硬化症（ALS）的组合治疗

    公开(公告)号：US20150290298A1

    公开(公告)日：2015-10-15

    申请号：US14442731

    申请日：2013-11-14

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Henn Benkler ,  Daniel Offen

    IPC: A61K38/44 ,  A61K45/06 ,  A61K38/17

    CPC classification number: A61K38/44 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K38/1709 ,  A61K38/43 ,  A61K45/06 ,  A61K48/00 ,  A61K48/005 ,  C12N2740/15043 ,  C12Y104/01003

    Abstract: A method of treating a disease selected from the group consisting of emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia, a neurodegenerative disorder, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia and a cognitive deficit in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a combination of at least two agents, wherein a first of said two agents upregulates an activity and/or expression of Nrf2 and a second of said two agents is a glutamatergic modulator, thereby treating the disease.

    Abstract translation: 一种在有需要的受试者中治疗选自肺气肿，败血症，败血症休克，缺血性损伤，脑缺血，神经变性疾病，脑膜炎，脑炎，出血，脑缺血，心脏缺血和认知缺陷的疾病的方法 被提供。 所述方法包括向受试者施用治疗有效量的至少两种试剂的组合，其中所述两种试剂中的第一种上调Nrf2的活性和/或表达，所述两种试剂中的第二种是谷氨酸能调节剂，由此处理 这种病。

    METHODS AND KITS FOR DIAGNOSING SCHIZOPHRENIA
    163.
    发明申请
    METHODS AND KITS FOR DIAGNOSING SCHIZOPHRENIA 审中-公开
    用于诊断SCHIZOPHRENIA的方法和工具

    公开(公告)号：US20150284793A1

    公开(公告)日：2015-10-08

    申请号：US14677068

    申请日：2015-04-02

    Applicant: Ramot at Tel-Aviv University Ltd. ,  Bar-IIan University

    Inventor： Daniel OFFEN ,  Ran Barzilay ,  Erez Levanon ,  Khen Khermesh-Shostak

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N2800/302

    Abstract: Methods and kits for diagnosing schizophrenia are disclosed. The diagnostic method comprises analyzing in a biological sample of a subject a level of A-to-I RNA editing of at least one CNS-expressed gene as set forth in Table 1, wherein an amount of the A-to-I RNA editing of the at least one gene below a predetermined level is indicative of schizophrenia in the subject.

    Abstract translation: 公开了用于诊断精神分裂症的方法和试剂盒。 该诊断方法包括在受试者的生物样品中分析如表1所示的至少一种CNS表达基因的A至I RNA编辑水平，其中A至I RNA编辑的量 低于预定水平的至少一种基因表明受试者中的精神分裂症。

    METHOD AND SYSTEM FOR ESTIMATING POSITION
    165.
    发明申请
    METHOD AND SYSTEM FOR ESTIMATING POSITION 有权
    估计位置的方法和系统

    公开(公告)号：US20150282112A1

    公开(公告)日：2015-10-01

    申请号：US14433686

    申请日：2013-10-03

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Oded Bialer ,  Dan Raphaeli ,  Antony J. Weiss

    IPC: H04W64/00 ,  H04L12/707

    CPC classification number: H04W64/00 ,  G01S1/02 ,  G01S5/0273 ,  G01S5/0278 ,  G01S19/39 ,  H04L45/24

    Abstract: A method of estimating a position of an object is disclosed. The method comprises receiving a plurality of signals transmitted between each of a respective plurality of reference stations of a known position and the object. The method further comprises, for each received signal: processing the signal using a matrix featuring a characteristic power delay profile and a characteristic signal waveform to provide a processed signal, and calculating a direct estimate of the position of the object based, at least in part, on the processed signals.

    Abstract translation: 公开了一种估计物体位置的方法。 该方法包括接收在已知位置的相应多个参考站和对象之间的每一个之间传输的多个信号。 该方法还包括：对于每个接收到的信号：使用特征为特征功率延迟分布和特征信号波形的矩阵来处理信号以提供经处理的信号，以及至少部分地基于物体的位置的直接估计 ，处理信号。

    METHODS AND KITS FOR PREDICTING PROGNOSIS OF CANCER USING SOLUBLE MORTALIN IN BLOOD
    166.
    发明申请
    METHODS AND KITS FOR PREDICTING PROGNOSIS OF CANCER USING SOLUBLE MORTALIN IN BLOOD 审中-公开
    用于预防血液中使用可溶性蛋白酶的癌症的方法和工具

    公开(公告)号：US20150268242A1

    公开(公告)日：2015-09-24

    申请号：US14434164

    申请日：2013-10-09

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  SEMMELWEIS UNIVERSITY

    Inventor： Zvi Fishelson ,  Zoltan Prohaszka

    IPC: G01N33/574

    CPC classification number: G01N33/57488 ,  G01N33/57407 ,  G01N33/57419 ,  G01N2333/4703

    Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.

    Abstract translation: 提供了确定受试者的体液中可溶性mortalin的存在或水平的方法，以及通过测定患有体内液体中可溶性mortalin的存在或水平来预测患有癌症的受试者（例如，实体瘤）的预后的方法 学科。 还提供了用于确定受试者体液中可溶性mortalin的存在和/或水平和/或预测被诊断患有癌症的受试者的预后的试剂盒，其包含至少两种针对所述mortal不同表位的mortal的不同抗体。

    LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR
    168.
    发明申请
    LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR 有权
    线性光学数字到模拟调制器

    公开(公告)号：US20150194982A1

    公开(公告)日：2015-07-09

    申请号：US14662343

    申请日：2015-03-19

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Yossef EHRLICHMAN ,  Ofer AMRANI ,  Shlomo RUSCHIN

    IPC: H03M1/70 ,  H04B10/54

    CPC classification number: H04B10/516 ,  G02F1/0121 ,  G02F1/015 ,  G02F1/225 ,  G02F7/00 ,  G02F2001/212 ,  G02F2203/19 ,  H03M1/002 ,  H03M1/70 ,  H04B10/2504 ,  H04B10/2575 ,  H04B10/505 ,  H04B10/5055 ,  H04B10/541 ,  H04B10/556

    Abstract: A modulator device for converting digital date into modulation of an optical signal includes an electronic input for receiving an input data word of N bits and an electrically controllable modulator for modulating the intensity of an optical signal, the modulator including M actuating electrodes where M≧N. An electrode actuating device, most preferably a digital-to-digital converter, operates actuating electrodes so that at least one electrode is actuated as a function of values of more than one bit of the input data word. According to an alternative, or supplementary, aspect of the invention, the set of electrodes includes at least one electrode having an effective area which is not interrelated to others of the set by factors of two. In one-preferred implementation, a Mach-Zehnder modulator also provides phase modulation to give QAM functionality. Another implementation employs a semiconductor laser.

    Abstract translation: 用于将数字日期转换为光信号调制的调制器装置包括用于接收N位输入数据字的电子输入端和用于调制光信号强度的电可控调制器，该调制器包括M个致动电极，其中M≥N 。 电极致动装置，最优选数字 - 数字转换器，操作致动电极，使得至少一个电极作为输入数据字的多于一位的值的函数被致动。 根据本发明的替代或补充方面，所述电极组包括至少一个电极，所述至少一个电极具有与所述组中的其它因素不相关的有效面积。 在一个优选的实现中，Mach-Zehnder调制器还提供相位调制以提供QAM功能。 另一个实施方案采用半导体激光器。

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