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28 条记录 (耗时 0.029 秒)

    CONTAINER CLOSURE OPERATED BY A CONNECTING DEVICE
    12.
    发明申请
    CONTAINER CLOSURE OPERATED BY A CONNECTING DEVICE 审中-公开

    公开(公告)号：US20190329943A1

    公开(公告)日：2019-10-31

    申请号：US16474726

    申请日：2017-12-18

    申请人： BRACCO IMAGING SPA

    发明人： Pier Lucio ANELLI ,  Cristina NEIRA ,  Andrea ROMEO ,  Alberto CANDOTTI ,  Marco LEONARDI

    IPC分类号： B65D47/24 ,  A61M39/22 ,  B65D47/36

    摘要： A solution is proposed for closing a mouth (125) of a container (110) of a liquid (105). A corresponding closure (135) comprises a cap (205) having fixing means (315) for fixing the cap (205) to the container (110), a delivery port (321) for delivering the liquid (105) from the container (110), a valve member (215) in a closed position wherein the valve member (215) closes the delivery port (321), a cap suction conduit (339) for suctioning air into the container (110) during the delivering of the liquid (105) and a connector (327) for connecting to a delivery device (805) of the liquid (105), the connector (327) being in fluid communication with the delivery port (321), a slider (220) slidebly coupled with the cap (205), the slider (220) having a slider suction conduit (440) for suctioning the air into the container (110) during the delivering of the liquid (105) slidebly coupled with the cap suction conduit (339), and a frangible element (345) closing the cap suction conduit (339) or the slider suction conduit (440), wherein the closure (135) is configured to cause the delivery device (805) during the connecting thereof to move inwards the container (110), in a fixed condition wherein the closure (135) is fixed to the container (110), and thus moving the valve member (215) inwards the container to an open position, wherein the valve member (215) opens the delivery port (321), and moving the slider (220) inwards the container to break the frangible element (345), thereby putting in fluid communication the slider suction conduit (440) with the cap suction conduit (339).

    Agents for magnetic imaging method
    14.
    发明授权
    Agents for magnetic imaging method 有权
    磁成像方法代理

    公开(公告)号：US07780952B2

    公开(公告)日：2010-08-24

    申请号：US10516781

    申请日：2003-06-02

    申请人： Silvio Aime ,  Valentina Mainero ,  Simonetta Chirich Geninatti ,  Claudia Cabella

    发明人： Silvio Aime ,  Valentina Mainero ,  Simonetta Chirich Geninatti ,  Claudia Cabella

    IPC分类号： A61B5/055

    CPC分类号： C07C237/12 ,  A61K41/009 ,  A61K41/0095 ,  A61K49/085 ,  C07C237/10 ,  C07C271/22 ,  C07C279/12 ,  C07C279/14

    摘要： The invention provides MRI detectable species of formula (I): Dp-Sn-Nm, wherein D is a MRI detectable moiety; S is a spacer; N is a molecule of a nutrient or pseudo-nutrient; n is 0 or an integer, m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.

    摘要翻译： 本发明提供式（I）的MRI可检测物质：Dp-Sn-Nm，其中D是可MRI检测部分; S是间隔物; N是营养物或假营养素的分子; n为0或整数，m为整数，p为整数。 这些化合物可用于向肿瘤细胞内化一定量的可MRI检测部分，其可区分地高于正常健康细胞内含量，从而允许诊断肿瘤。 MRI可检测部分的内化包括营养物或假营养物质输送系统。 优选的式（I）化合物是其中D是顺磁性金属离子的螯合络合物。

    CONTAINER CLOSURE OPERATED BY ROTATION
    19.
    发明申请
    CONTAINER CLOSURE OPERATED BY ROTATION 审中-公开

    公开(公告)号：US20190329944A1

    公开(公告)日：2019-10-31

    申请号：US16474838

    申请日：2017-12-18

    申请人： BRACCO IMAGING SPA

    发明人： Marco LEONARDI ,  Cristina NEIRA ,  Andrea ROMEO ,  Marta PALENZONA

    IPC分类号： B65D47/24 ,  B65D47/36 ,  A61M39/22

    摘要： A solution is proposed for closing a mouth (125) of a container (110) of a liquid (105). A corresponding closure (135) comprises a cap (205) having fixing means (318) for fixing the cap (205) to the container (110), the cap (205) being rotatable around a longitudinal axis (203) of the container (110) in a fixed condition wherein the closure (135) is fixed to the container (110), a delivery port (336) for delivering the liquid (105) from the container (110), a cap suction conduit (345) for suctioning air into the container (110) during the delivering of the liquid (105) and a connector (342) for connecting a delivery device (805) of the liquid (105), the connector (342) being in fluid communication with the delivery port (336), a cursor (210) having a thread (406) for screwing the cursor (205) with respect to the container (110), a valve member (424) in a closed position wherein the valve member (215) closes the delivery port (336), and a cursor suction conduit (433) slidebly coupled with the cap suction conduit (345), a frangible element (351) closing the cap suction conduit (345) or the cursor suction conduit (433), and dragging means (327, 409) for dragging the cursor (210) into rotation by the cap (205), wherein the closure (135) is configured to cause the cursor (210) to slide with respect to the cap (205) in response to at least one rotation of the cap (205) thereby moving the cursor suction conduit (433) to break the frangible element (351), putting in fluid communication the cursor suction conduit (433) with the cap suction conduit (345), and moving the valve member (424) to an open position, wherein the valve member (215) opens the delivery port (336).

    Fibrin-binding peptides and conjugates thereof
    20.
    发明授权
    Fibrin-binding peptides and conjugates thereof 有权
    纤维蛋白结合肽及其缀合物

    公开(公告)号：US08466107B2

    公开(公告)日：2013-06-18

    申请号：US13598811

    申请日：2012-08-30

    申请人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61K38/36

    CPC分类号： A61K49/14 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/124 ,  C07K7/06 ,  G01N33/532 ,  G01N33/574 ,  G01N33/86 ,  G01N2500/04

    摘要： Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

    摘要翻译： 提供了与先前已知的纤维蛋白结合肽相比具有高结合亲和力和优异物理特性的纤维蛋白结合肽。 这些纤维蛋白结合肽可以缀合到可检测标记或治疗剂，并用于检测和促进治疗与血纤维蛋白如血栓形成和血管生成和肿瘤状况有关的病理状况。 这些肽可以用于诸如MRI，超声和核医学成像（例如PET，闪烁照相成像等）的成像过程中。 肽也可以在治疗上使用。 本发明还提供了制备和使用这些肽及其缀合物的方法和方法。