公开(公告)号：US06982535B2

公开(公告)日：2006-01-03

申请号：US10502626

申请日：2002-06-28

申请人： Kouji Kosaka

发明人： Kouji Kosaka

IPC分类号： B23Q5/28

CPC分类号： H02N2/028 ,  H02N2/021 ,  H02N2/06

摘要： In a feed drive apparatus wherein a moving element 27 is driven by drive legs 21, 22 having extension/contraction deforming parts 23 and shear deforming parts 24, sine wave drive voltages are respectively applied to the extension/contraction deforming parts 23 and shear deforming parts 24 of the drive legs 21, 22 in order to permit high speed operation, and make the average voltage effectively zero.

摘要翻译： 在具有伸缩变形部23和剪切变形部24的驱动支脚21,22驱动移动元件27的进给驱动装置中，将正弦波驱动电压分别施加到延伸/收缩变形部23和剪切变形部 24，以允许高速操作，并使平均电压有效地为零。

公开(公告)号：US07979765B2

公开(公告)日：2011-07-12

申请号：US12442996

申请日：2007-09-25

申请人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G01R31/28 ,  G06F11/00

CPC分类号： G11C29/10 ,  G01R31/31721 ,  G01R31/31813 ,  G01R31/31917 ,  G11C29/56004

摘要： Provided are a generation device and the like for generating a test vector which can reduce capture power efficiently. The generation device 100 generates a test vector for a logic circuit by assigning logic values to each of a plurality of unspecified bits (X-bits) included in a test cube. The generation device 100 includes a selection unit 101 for selecting, among the plurality of X-bits, a target X-bit, which is a target of assigning a logic value, a capture transition metric calculation unit 103 for calculating capture transition metric caused by a test cube including an X-bit, and a logic value assignment unit 105 for assigning, to the selected target X-bit, a logic value which causes the smaller capture transition metric, by applying the capture transition metric calculation means to a first test cube obtained by assigning a logic value 0 to the selected target X-bit and to a second test cube obtained by assigning a logic value 1 to the selected target X-bit, and by comparing a capture transition metric caused by a first test cube and a capture transition metric caused by a second test cube.

摘要翻译： 提供了用于生成能够有效地降低捕获功率的测试向量的生成装置等。 生成装置100通过向包括在测试立方体中的多个未指定位（X位）中的每一个分配逻辑值来生成用于逻辑电路的测试向量。 生成装置100包括：选择单元101，用于在多个X位中选择作为分配逻辑值的目标的目标X位;捕获转移度量计算单元103，用于计算由 包括X位的测试立方体和用于通过将捕获转移度量计算装置应用于第一测试来向所选择的目标X位分配导致较小捕获转换度量的逻辑值的逻辑值分配单元105 通过将逻辑值0分配给所选择的目标X位获得的立方体以及通过将逻辑值1分配给所选择的目标X位获得的第二测试立方体，并且通过将由第一测试立方体引起的捕获转变度量与 由第二个测试立方体引起的捕获转换度量。

公开(公告)号：US07962822B2

公开(公告)日：2011-06-14

申请号：US12235628

申请日：2008-09-23

申请人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G01R31/28

CPC分类号： G01R31/318544 ,  G01R31/318502

摘要： A generation apparatus and the like for generating a test vector set capable of reducing differences in a logic value generated before and after a scan capture for outputs from scan cells included in a full-scan sequential circuit are provided. A generation apparatus 200 generating an initial test vector set 216 for a logic circuit includes a target vector identification unit 204 identifying a test vector satisfying a predetermined criterion and to be selected for the number of bits (the number of bit transitions) whose logic values differ before and after scan capture with respect to outputs from scan cells included in the sequential circuit, from among test vectors in the initial test vector set 216, and a test vector set conversion unit 206 converting the test vector identified by the test vector identification unit 204 and to be selected so as to reduce the number of bit transitions with respect to outputs from the scan cells included in the sequential circuit.

摘要翻译： 提供了一种用于生成能够减少在扫描捕获之前和之后产生的逻辑值中的差异的测试向量集的生成装置等，用于从全扫描时序电路中包括的扫描单元的输出。 生成用于逻辑电路的初始测试向量集合216的生成装置200包括：目标矢量识别单元204，其识别满足预定标准的测试向量，并且对于其逻辑值不同的位数（位数转换的数量）来选择 相对于包括在顺序电路中的扫描单元的输出，从初始测试向量集合216的测试向量中的扫描捕获之前和之后，以及转换由测试向量识别单元204识别的测试向量的测试向量集合转换单元206 并且被选择为减少相对于包括在顺序电路中的扫描单元的输出的位转换的数量。

公开(公告)号：US20100004327A1

公开(公告)日：2010-01-07

申请号：US12504823

申请日：2009-07-17

申请人： Masayoshi Shichiri ,  Yujiro Tanaka

发明人： Masayoshi Shichiri ,  Yujiro Tanaka

IPC分类号： A61K31/395

CPC分类号： A61K31/395 ,  A61K31/496 ,  G01N33/5011

摘要： The present invention provides novel angiogenesis inhibitors effective, safe and highly practical for inhibition of angiogenesis in various diseases, and a method for screening the same. The active ingredients of the angiogenesis inhibitors of the present invention comprise ansamycin antibiotics such as rifampicin, rifamycin SV and 3-formyl rifamycin, which have long been used extensively as antibacterial agents for treating tuberculosis or Gram-positive bacterial infections. The active ingredients of the present invention have excellent angiogenesis-inhibiting activity. The angiogenesis inhibitor of the present invention is effective for inhibition of angiogenesis in malignant tumors, diabetic retinopathy, retinal angiogenesis, inflammatory diseases, and angiogenesis accompanying cardiovascular remodeling, etc., and can be used as therapeutic agents against each disease, etc. Further, the screening method of the present invention makes it possible to perform an effective screening of angiogenesis-inhibiting substances by detecting angiogenesis-inhibiting signals based on gene expression levels.

摘要翻译： 本发明提供了用于抑制各种疾病中的血管发生的有效，安全和高度实用的新型血管生成抑制剂及其筛选方法。 本发明的血管发生抑制剂的活性成分包括长时久以来被广泛用作治疗结核病或革兰氏阳性细菌感染的抗菌剂的安莎霉素抗生素如利福平，利福霉素SV和3-甲酰基利福霉素。 本发明的活性成分具有优异的血管生成抑制活性。 本发明的血管生成抑制剂对于抑制恶性肿瘤，糖尿病性视网膜病变，视网膜血管生成，炎症性疾病以及伴随心血管重塑等的血管发生等，对于抑制血管生成有效，可用作针对各种疾病的治疗剂等。另外， 通过本发明的筛选方法，可以通过基于基因表达水平检测血管生成抑制信号来进行血管新生抑制物质的有效筛选。

公开(公告)号：US07601348B2

公开(公告)日：2009-10-13

申请号：US10568544

申请日：2004-07-09

申请人： Reiji Kannagi ,  Mineko Izawa ,  Takashi Muramatsu ,  Kenji Uchimura ,  Hideaki Hosokawa

发明人： Reiji Kannagi ,  Mineko Izawa ,  Takashi Muramatsu ,  Kenji Uchimura ,  Hideaki Hosokawa

IPC分类号： A61K39/395

CPC分类号： G01N33/57419 ,  G01N2333/91097 ,  G01N2400/02

摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.

摘要翻译： 本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂 其中。 本发明人发现，GlcNAc-6-磺基转移酶同工酶，糖残基的硫酸化酶在非癌结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织中的分布存在显着差异。 此外，本发明人将该发现应用于诊断，并发现通过测定来自患者或粪便样品的组织中GlcNAc-6-硫酸化糖残基的确定范围来特异性检测结肠直肠癌和腺瘤。 与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查 结肠直肠癌和结直肠腺瘤。

公开(公告)号：US07553624B2

公开(公告)日：2009-06-30

申请号：US10557906

申请日：2004-05-20

申请人： Takeharu Nagai ,  Atsushi Miyawaki

发明人： Takeharu Nagai ,  Atsushi Miyawaki

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  C07H19/04 ,  C07H21/02

CPC分类号： G01N33/533

摘要： The present invention provides a method of analyzing the physiological function of a target substance by inactivating the physiological function of the target substance, comprising the steps of: (a) binding to the target substance a photoactive compound represented by formula (I): (in the formula, Q is a group for binding this compound with the target substance) to form a composite comprising the target substance and the photoactive compound; and (b) irradiating the obtained composite with light to inactivate the function of the target substance to which the photoactive compound has been bound, or to inactivate the function of the target substance at the site where the photoactive compound has been bound.

摘要翻译： 本发明提供了通过使目标物质的生理功能失活来分析目标物质的生理功能的方法，包括以下步骤：（a）与目标物质结合由式（I）表示的光活性化合物：（在 式中，Q为与化合物与目标物质结合的基团），形成包含目标物质和光活性化合物的复合体; 和（b）用光照射得到的复合物，使光活性化合物结合的目标物质的功能失活，或者使光活性化合物结合的位置失活目标物质的功能。

公开(公告)号：US07304315B2

公开(公告)日：2007-12-04

申请号：US11404248

申请日：2006-04-13

申请人： Yoshinori Iketaki ,  Masaaki Fujii ,  Takeshi Watanabe ,  Takashige Omatsu ,  Kimihisa Yamamoto ,  Toshio Suzuki

发明人： Yoshinori Iketaki ,  Masaaki Fujii ,  Takeshi Watanabe ,  Takashige Omatsu ,  Kimihisa Yamamoto ,  Toshio Suzuki

IPC分类号： G01N21/64 ,  G01J3/00

CPC分类号： G01N21/6458 ,  G01N21/645 ,  G01N2021/6419

摘要： A three-dimensional analyzing device includes a first beam source for generating a first beam, a second beam source for generating a second beam, an optical system for spatially overlapping the first and second beams at least partly and irradiating the beams onto a specimen to three-dimensionally confine a photoactive region in a specimen, and a photo acceptance element for accepting a response light emitted from the photoactive region. Preferably, the device further includes an operation unit for calculating a correlation function of a response light in the time domain based on the output of the photo acceptance element to analyze a desired physical value of the specimen.

摘要翻译： 三维分析装置包括用于产生第一光束的第一光束源，用于产生第二光束的第二光束源，至少部分地将第一和第二光束空间重叠的光学系统，并将光束照射到样品上至三 视觉上将光活性区域限制在样本中，以及用于接受从光活性区域发射的响应光的光接收元件。 优选地，所述装置还包括操作单元，用于基于所述光接收元件的输出来计算所述时域中的响应光的相关函数，以分析所述样本的期望物理值。

公开(公告)号：US07220986B2

公开(公告)日：2007-05-22

申请号：US10490476

申请日：2002-07-31

申请人： Masahiro Hiramoto ,  Masaaki Yokoyama

发明人： Masahiro Hiramoto ,  Masaaki Yokoyama

IPC分类号： H01L29/08

CPC分类号： H01L51/4206 ,  H01L27/305 ,  H01L51/0053 ,  H01L51/0064 ,  H01L51/0077 ,  H01L51/0078 ,  H01L51/0081 ,  H01L2251/308 ,  Y02E10/549 ,  Y02P70/521

摘要： A NTCDA single crystal is used as a photoelectric current multiplier layer, and Au thin films are formed as electrodes on the opposite surfaces of the multiplier layer by a vapor deposition method to form a sandwich type cell. When a voltage is applied to the NTCDA single crystal by the electrodes from a dc power source and a monochromatic light is applied, a multiplied photoelectric current flows between the electrodes. A rise of this element at light-on is considerably faster than when a vapor-deposited layer is used as a photoelectric current multiplier layer to permit a faster response.

公开(公告)号：US08110519B2

公开(公告)日：2012-02-07

申请号：US10590206

申请日：2005-03-07

申请人： Shu Kobayashi ,  Kuniaki Okamoto ,  Ryo Akiyama ,  Keiji Ohno ,  Yoshio Inagaki

发明人： Shu Kobayashi ,  Kuniaki Okamoto ,  Ryo Akiyama ,  Keiji Ohno ,  Yoshio Inagaki

IPC分类号： B01J31/06 ,  B01J31/00 ,  B01J31/16 ,  B01J31/22 ,  B01J23/40 ,  B01J23/42 ,  B01J23/44 ,  B01J23/46 ,  B01J23/52 ,  B01J23/75 ,  B01J23/755

CPC分类号： C07C67/31 ,  B01J31/069 ,  B01J31/165 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C17/14 ,  C07C45/68 ,  C07C49/796 ,  C07C67/343 ,  C08F212/08 ,  C08F212/14 ,  C07C22/04 ,  C07C69/732 ,  C07C69/618

摘要： The objective is to present compositions obtained by supporting by polymers micro clusters of transition metals and the like that are useful as catalysts in various reactions and, once used, are readily recovered and reused.A polymer-supported metal cluster composition is obtained by supporting a transition metal by a cross-linked polymer, and the polymer-supported cluster composition is characterized by the cross-linked polymer obtained by cross-linking of a cross-linkable polymer containing a hydrophilic side chain and a hydrophobic side chain group having a cross-linkable functional group. This polymer-supported metal cluster composition is, for example, preferably formed by first forming a micelle composed of the metal clusters supported by the cross-linkable polymer in a suitable solution and subsequently subjecting the cross-linkable polymer to a cross-linking reaction. The composition is useful as a catalyst and the like in hydrogenation reactions, dehydrogenation reactions, allylic substitution reactions, oxidation reactions, coupling reactions and carbonylation reactions.

摘要翻译： 目的是提供通过聚合物支撑的组合物，所述过渡金属等的微簇等可用作各种反应中的催化剂，并且一旦使用，就容易回收和重复使用。 聚合物负载的金属簇组合物通过用交联聚合物负载过渡金属而获得，聚合物负载的簇组合物的特征在于通过交联含有亲水性的交联聚合物而获得的交联聚合物 侧链和具有可交联官能团的疏水侧链基团。 该聚合物负载的金属簇组合物例如优选通过首先在合适的溶液中形成由可交联聚合物负载的金属簇构成的胶束，然后使可交联聚合物进行交联反应而形成。 该组合物可用作氢化反应，脱氢反应，烯丙基取代反应，氧化反应，偶联反应和羰基化反应中的催化剂等。

公开(公告)号：US07858346B2

公开(公告)日：2010-12-28

申请号：US10542248

申请日：2004-02-02

申请人： Takahisa Furukawa

发明人： Takahisa Furukawa

IPC分类号： C12P21/04 ,  C12N15/85 ,  C12N15/63 ,  C12N5/00 ,  C12N15/11 ,  C07K14/00

CPC分类号： G01N33/6875 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  G01N2500/00

摘要： The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an agent for preventing, treating or suppressing progression of a retinal disease including retinal degeneration. In addition, the present medicine is useful, for example, as an agent for inducing differentiation from a retinal stem cell into a retinal photoreceptor cell, in the transplantation of a cell into the retina of patients suffering from retinal diseases.

摘要翻译： 本发明提供一种药物，其包含（a）Otx2蛋白或其部分肽或其盐，或（b）编码Otx2蛋白或其部分肽的DNA或RNA。 本药可用作预防，治疗或抑制包括视网膜变性的视网膜疾病进展的药剂。 此外，本发明的药物可用于例如将细胞移植到患有视网膜疾病的患者的视网膜中作为诱导从视网膜干细胞分化为视网膜感光细胞的药剂。