公开(公告)号：US20210260103A1

公开(公告)日：2021-08-26

申请号：US17319292

申请日：2021-05-13

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61P31/00 ,  A61P35/00 ,  A61K9/14 ,  A61K47/24

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Kits for preparing suspension compositions of the present invention are provided as well.

公开(公告)号：US20200345763A1

公开(公告)日：2020-11-05

申请号：US16929837

申请日：2020-07-15

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61P31/00 ,  A61P35/00 ,  A61K9/14 ,  A61K47/24

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.

公开(公告)号：US10328100B2

公开(公告)日：2019-06-25

申请号：US14744726

申请日：2015-06-19

Applicant: Amorphical Ltd.

Inventor： Shmuel Bentov ,  Amir Sagi ,  Amir Berman ,  Assaf Shechter

IPC: A61K9/00 ,  A61K31/66 ,  A61K33/10 ,  A61K38/17 ,  C07K14/435

Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

公开(公告)号：US20160045546A1

公开(公告)日：2016-02-18

申请号：US14744726

申请日：2015-06-19

Applicant: Amorphical Ltd.

Inventor： Shmuel BENTOV ,  Amir SAGI ,  Amir BERMAN ,  Assaf SHECHTER

IPC: A61K33/10 ,  A61K9/00 ,  A61K38/17

CPC classification number: A61K33/10 ,  A61K9/0053 ,  A61K31/66 ,  A61K38/17 ,  A61K38/1767 ,  C07K14/43509 ,  A61K2300/00

Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

Abstract translation: 提供了含有无定形碳酸钙（ACC）的组合物和稳定所述碳酸钙的无定形形式的至少一种磷酸化肽。 特别地，肽可以选自本发明也提供的甲壳素蛋白，即GAP65，GAP22，GAP21和GAP12（本文也称为GAP10）。 所述组合物可用于药物和营养制剂中。

公开(公告)号：US11033576B2

公开(公告)日：2021-06-15

申请号：US16929837

申请日：2020-07-15

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum

IPC: A61K31/00 ,  A61K33/10 ,  A61K9/00 ,  A61K9/14 ,  A61K9/10 ,  A61P35/00 ,  A61P31/00 ,  A61K47/24

Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.

公开(公告)号：US10758566B2

公开(公告)日：2020-09-01

申请号：US16069762

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US20190022133A1

公开(公告)日：2019-01-24

申请号：US16050651

申请日：2018-07-31

Applicant: AMORPHICAL LTD.

Inventor： Amir SAGI ,  Assaf SHECHTER ,  Galit SHALTIEL-GOLD ,  Michal DANIELY ,  Oren MEIRON

IPC: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

公开(公告)号：US10125262B2

公开(公告)日：2018-11-13

申请号：US15370623

申请日：2016-12-06

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C01F11/18 ,  C09C1/02 ,  B82Y30/00 ,  A61K33/10 ,  C08K3/26 ,  C08K5/092 ,  C08K5/17 ,  C08K5/521 ,  C08K5/5399 ,  C08L5/00 ,  D21H17/00 ,  A23L33/16 ,  C09D17/00 ,  C09J11/04

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

公开(公告)号：US20170208827A1

公开(公告)日：2017-07-27

申请号：US15329664

申请日：2015-07-30

Applicant: AMORPHICAL LTD.

Inventor： Ali Abo Riziq ,  Sharon Hershkovitz ,  Yosef Ben ,  Yigal Blum

IPC: A23C9/13 ,  A23L33/16 ,  C01F11/18

CPC classification number: A61K33/10 ,  A23C9/1322 ,  A23C9/1522 ,  A23C11/00 ,  A23C13/12 ,  A23C19/0684 ,  A23C19/0765 ,  A23C19/0921 ,  A23L33/16 ,  A23V2002/00 ,  A23V2250/032 ,  A23V2250/1578 ,  A23V2250/1886 ,  A23V2250/192 ,  A23V2250/5482 ,  A61K9/0014 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  C01F11/18 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72

Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.

公开(公告)号：US20170081520A1

公开(公告)日：2017-03-23

申请号：US15370623

申请日：2016-12-06

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C09C1/02 ,  C09D17/00 ,  A61K33/10 ,  C08K3/26 ,  A23L33/16 ,  C08K5/092 ,  C08K5/17 ,  C09J11/04 ,  D21H17/00 ,  C01F11/18 ,  C08K5/521

CPC classification number: C09C1/021 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/10 ,  B82Y30/00 ,  C01F11/182 ,  C01F11/183 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/30 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/22 ,  C01P2006/36 ,  C01P2006/82 ,  C08K3/26 ,  C08K5/092 ,  C08K5/175 ,  C08K5/521 ,  C08K5/5399 ,  C08K2003/265 ,  C08L5/00 ,  C09D17/004 ,  C09J11/04 ,  D21H17/74

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.