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    Cyclic amine phenyl beta-3 adrenergic receptor agonists
    11.
    发明授权
    Cyclic amine phenyl beta-3 adrenergic receptor agonists 失效
    环胺苯基β-3肾上腺素能受体激动剂

    公开(公告)号：US07022716B2

    公开(公告)日：2006-04-04

    申请号：US10330576

    申请日：2002-12-27

    Applicant: Baihua Hu ,  Fuk-Wah Sum ,  Michael Sotirios Malamas

    Inventor： Baihua Hu ,  Fuk-Wah Sum ,  Michael Sotirios Malamas

    IPC: A61K31/4468 ,  C07D213/72

    CPC classification number: C07D401/10 ,  C07D211/58 ,  C07D223/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/10 ,  C07D417/14

    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

    Abstract translation: 本发明提供具有以下结构的式I化合物：其中R 1，R 2，R 3，R 4， >，R 5，T，T 1，T 2和X如上所定义，或其药学上可接受的盐，它们是 可用于治疗或抑制与胰岛素抵抗或高血糖相关的代谢紊乱（通常与肥胖或葡萄糖不耐受相关），动脉粥样硬化，胃肠道疾病，神经源性炎症，青光眼，高眼压症和尿频; 并且特别可用于治疗或抑制II型糖尿病。

    PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS
    14.
    发明申请
    PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权
    含有蛋白质的化合物作为蛋白激酶抑制剂

    公开(公告)号：US20120220551A1

    公开(公告)日：2012-08-30

    申请号：US13402335

    申请日：2012-02-22

    Applicant: Baihua Hu ,  Kan He ,  Minsheng Zhang

    Inventor： Baihua Hu ,  Kan He ,  Minsheng Zhang

    IPC: A61K31/675 ,  A61P35/00 ,  C07F9/6509 ,  C07F9/58 ,  C07F9/6558

    CPC classification number: C07F9/58 ,  C07F9/650952 ,  C07F9/65583

    Abstract: The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.

    Abstract translation: 本发明涉及可以调节蛋白激酶活性的由式​​（I）表示的化合物。 本发明还涉及包含式（I）化合物的组合物，以及用于合成和使用该化合物以预防或治疗ALK或cMet介导的病症或病症的方法。

    Substituted sulfonamide-indoles
    17.
    发明授权
    Substituted sulfonamide-indoles 失效
    取代磺酰胺 - 吲哚

    公开(公告)号：US07442805B2

    公开(公告)日：2008-10-28

    申请号：US10947839

    申请日：2004-09-23

    Applicant: Baihua Hu

    Inventor： Baihua Hu

    IPC: C07D209/02 ,  C07D209/42 ,  A61K31/405

    CPC classification number: C07D209/42 ,  C07D403/04

    Abstract: The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.

    Abstract translation: 本发明一般涉及取代磺酰胺吲哚如取代磺酰胺吲哚，以及使用它们的方法。

    Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia
    18.
    发明授权
    Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia 失效
    可用于治疗胰岛素抵抗和高血糖症的嘧啶衍生物

    公开(公告)号：US07423044B2

    公开(公告)日：2008-09-09

    申请号：US10655471

    申请日：2003-09-04

    Applicant: Baihua Hu

    Inventor： Baihua Hu

    IPC: C07D239/34 ,  A61K31/505

    CPC classification number: C07D471/04 ,  C07D239/34 ,  C07D239/70 ,  C07D401/04

    Abstract: This invention provides compounds of Formula I having the structure: wherein: B is alkyl of 1-4 carbons or alkoxy of 1-4 carbons; R1 is aryl or Het optionally substituted with R6; R2 and R3 are each independently, alkyl of 1-4 carbons, CF3, aryl or Het substituted with R6, or R2 and R3 are combined to form a cycloalkyl or heterocyclic ring optionally substituted with alkyl, benzyl, or acyl; R4, and R5 are each independently, hydrogen, halogen, alkyl of 1-4 carbons, CO2R7, SO2NHR7, CONHR7, CN, NO2 or CF3; R6 is hydrogen, halogen, NO2, alkyl of 1-4 carbons, alkoxy of 1-4 carbons, alkylcarbonyloxy of 2-7 carbon atoms, alkylcarbonyl of 2-7 carbon atoms, CF3, or COOH; and R7 is hydrogen, alkyl of 1-4 carbons, or alkylaryl where aryl group is substituted with R6; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

    Abstract translation: 本发明提供具有以下结构的式I化合物：其中：B为1-4个碳的烷基或1-4个碳的烷氧基; R 1是任选被R 6取代的芳基或Het; R 2和R 3各自独立地为1-4个碳的烷基，CF 3，被R 6取代的芳基或Het 或R 2和R 3 3结合形成任选被烷基，苄基或酰基取代的环烷基或杂环; R 4和R 5各自独立地为氢，卤素，1-4个碳的烷基，CO 2 R 7， SO 2，NH 2，NH 2，NH 3，CONHR 7，CN，NO 2或CF 3 R 6是氢，卤素，NO 2，1-4个碳的烷基，1-4个碳的烷氧基，2-7个碳原子的烷基羰基氧基，2- 7个碳原子，CF 3 3或COOH; R 7是氢，1-4个碳的烷基或芳基，其中芳基被R 6取代; 或其药学上可接受的盐，其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。

    Substituted indoles
    19.
    发明授权
    Substituted indoles 失效
    取代的吲哚

    公开(公告)号：US07332521B2

    公开(公告)日：2008-02-19

    申请号：US10947903

    申请日：2004-09-23

    Applicant: Baihua Hu

    Inventor： Baihua Hu

    IPC: A61K31/404 ,  C07D209/04

    CPC classification number: C07D409/12 ,  C07D209/42

    Abstract: The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them.

    Abstract translation: 本发明一般涉及取代的吲哚如取代的1H-吲哚-2-羧酸衍生物及其使用方法。

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