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11.发明授权公开(公告)号：US08422632B2
公开(公告)日：2013-04-16
申请号：US13168041
申请日：2011-06-24
Applicant: Brian Fowler , Andrew May
Inventor： Brian Fowler , Andrew May
IPC: G01N23/20
CPC classification number: G01N23/20025
Abstract: An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
Abstract translation: 集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。 第一结构被配置为提供通过多个通道的一种或多种材料的流动。 集成流体回路还包括耦合到衬底层的第二结构。 第二结构包括被配置为接收致动压力的多个控制通道。 集成流体回路的特征在于厚度小于1.5mm。
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公开(公告)号：US20130005585A1
公开(公告)日：2013-01-03
申请号：US13476911
申请日：2012-05-21
Applicant: Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
Inventor： Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
CPC classification number: C12Q1/6855 , C12N15/10 , C12N15/1065 , C12N15/65 , C12N15/66 , C12Q1/686 , C12Q1/6874
Abstract: Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.
Abstract translation: 本文所描述的方法可用于掺入一个或多个衔接子和/或核苷酸标签和/或条形码核苷酸序列，一个或多个靶核苷酸序列。 在具体实施方案中，产生具有适配器（例如适合用于高通量DNA测序）的核酸片段。 在其它实施方案中，关于反应混合物的信息被编码成反应产物。 本文还描述了可用于扩增一种或多种靶核酸以准备应用如双向核酸测序的方法和试剂盒。 在具体实施方案中，本发明的方法还需要进行双向DNA测序。 本文还描述了通过引物延伸来编码和检测和/或定量等位基因的方法。
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公开(公告)号：US20120261007A1
公开(公告)日：2012-10-18
申请号：US13295028
申请日：2011-11-11
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: F16K31/12
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造成品率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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公开(公告)号：US20120132192A1
公开(公告)日：2012-05-31
申请号：US12955006
申请日：2010-11-29
Applicant: Brian Fowler , Paul Dusky
Inventor： Brian Fowler , Paul Dusky
IPC: F24B1/192
CPC classification number: F24B1/192 , Y10T29/18 , Y10T29/496 , Y10T29/49826 , Y10T29/49888
Abstract: A fireplace screen comprising a mesh structure positionable about an outer surface of a fireplace opening. The mesh structure is shaped to cover the fireplace opening. Holes in the mesh structure are configured to promote an inflow of air external to a fireplace through the mesh structure and a vertical circulation of the air across an interior planar surface of the mesh structure located outside of the fireplace opening.
Abstract translation: 一种壁炉筛，包括可围绕壁炉开口的外表面定位的网状结构。 网状结构被成形为覆盖壁炉开口。 网状结构中的孔构造成促进通过网状结构的壁炉外部的空气的流入，以及空气横跨位于壁炉开口外部的网状结构的内部平坦表面的垂直循环。
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公开(公告)号：US20100230613A1
公开(公告)日：2010-09-16
申请号：US12688462
申请日：2010-01-15
Applicant: Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
Inventor： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC: G01J1/58
CPC classification number: G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
Abstract translation: 本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。 提供了减少使用微流体装置期间的混合时间的方法。 微流控装置和相关的制造方法具有提高的制造产率。 提供改进的装置和相关系统用于向微流体装置提供受控的压力。 提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。 微流控装置和相关方法提供了改进的样品与试剂混合比控制。 微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。 提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。 提供了用于改进微流体装置的荧光成像的方法和系统。
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Patent Agency Ranking
公开(公告)号：US07452726B2
公开(公告)日：2008-11-18
申请号：US10734963
申请日：2003-12-11
Applicant: Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
Inventor： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
CPC classification number: G01N35/00 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , G01N15/1456 , G01N15/1468 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , Y10T436/11 , Y10T436/2575
Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
Abstract translation: 本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。 本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。 本发明还提供用于进行这些操作和分析的微流体机理。 这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。 此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。 因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中 其他，串联和/或并行。 此外，这些组合可以使微流体系统能够重复使用。 此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。 因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。 这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。
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公开(公告)号：US07312085B2
公开(公告)日：2007-12-25
申请号：US10405953
申请日：2003-04-01
Applicant: Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
Inventor： Hou-Pu Chou , Antoine Daridon , Kevin Farrell , Brian Fowler , Yish-Hann Liau , Ian D. Manger , Hany Ramez Nassef , William Throndset
CPC classification number: G01N35/00 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , G01N15/1456 , G01N15/1468 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , Y10T436/11 , Y10T436/2575
Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.
Abstract translation: 本发明提供了用于微流体操纵和/或检测诸如细胞和/或珠粒的装置，方法和试剂盒的系统。 本发明提供了用于微粒操作和/或分析颗粒例如细胞，病毒，细胞器，珠粒和/或囊泡的装置，方法和试剂盒的系统。 本发明还提供用于进行这些操作和分析的微流体机理。 这些机制可以实现颗粒的控制输入，运动/定位，保留/定位，处理，测量，释放和/或输出。 此外，这些机制可以以任何合适的顺序组合和/或在系统内任何适当次数使用。 因此，这些组合可以允许将粒子分类，培养，混合，处理和/或测定为单粒子，粒子的混合组，粒子阵列，非均匀粒子组和/或均匀粒子组，其中 其他，串联和/或并行。 此外，这些组合可以使微流体系统能够重复使用。 此外，这些组合可以允许在比以前可能的更短的时间尺度上测量颗粒对治疗的反应。 因此，本发明的系统可以允许广泛范围的细胞和颗粒测定，例如药物筛选，细胞特征化，研究研究和/或临床分析等，以缩小到微流体大小。 这种按比例缩小的测定可能使用较少的样品和试剂，可能较少的劳动密集型和/或可能比可比较的大流控测定更具信息性。
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公开(公告)号：US07283515B2
公开(公告)日：2007-10-16
申请号：US10386527
申请日：2003-03-13
Applicant: Brian Fowler
Inventor： Brian Fowler
IPC: H04L12/66
CPC classification number: H04L65/1043 , H04L29/06027 , H04L29/12 , H04L29/12018 , H04L61/10 , H04L65/103 , H04L65/104 , H04L65/1069 , H04M7/128
Abstract: A telephony network for enabling the origination and termination of telephone calls between one or more subscriber terminals connected to a public packet network with an open addressing protocol and one or more non-subscriber terminals connected to a PSTN network. Subscribers to the telephony network have E.164 numbers mapped to their current IP address and published by a mapping server so other subscribers and non-subscribers can call the subscriber. The mapped information is published on either a HTML or XML page for direct use over the Internet by other subscribers or for use by a gateway device. The gateway device enables non-subscribers on the PSTN to directly call subscribers. Calls between subscribers completely by-pass the PSTN or the cellular network if BlueTooth or Wi-Fi enabled terminals are used. Subscribers can also call anyone with a phone number whether they are a subscriber or not.
Abstract translation: 一种电话网络，用于使连接到具有开放寻址协议的公共分组网络的一个或多个用户终端和连接到PSTN网络的一个或多个非用户终端之间的电话呼叫的发起和终止。 电话网络的订户具有映射到其当前IP地址并由映射服务器发布的E.164号码，因此其他用户和非订户可以呼叫用户。 映射的信息在HTML或XML页面上发布，供其他用户在Internet上直接使用或由网关设备使用。 网关设备使得PSTN上的非用户能够直接呼叫用户。 如果使用蓝牙或Wi-Fi终端，用户之间的呼叫将完全绕过PSTN或蜂窝网络。 用户也可以打电话给任何人，无论他们是否是用户。
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公开(公告)号：US07077949B2
公开(公告)日：2006-07-18
申请号：US10332931
申请日：2001-07-10
Applicant: Ernst Antonius Bakker , David John Bridger , Hendricus Arien Dirkse , Stephen Brian Fowler
Inventor： Ernst Antonius Bakker , David John Bridger , Hendricus Arien Dirkse , Stephen Brian Fowler
CPC classification number: C10G11/18
Abstract: A fluidized catalytic cracking reactor vessel having at its upper end means to separate catalyst particles from an effluent of a dilute phase fluidized catalytic cracking reactor riser, which separation means are fluidly connected to the downstream part of the reactor riser, fluidly connected with means to discharge the cleaned reactor riser effluent from the vessel and fluidly connected to means to discharge the separated catalyst to the lower end of the vessel, the vessel further having at its lower end means to discharge catalyst from the reactor vessel, wherein (a) between the side wall of the vessel and the separation means a shield is present, resulting in an exterior space between the vessel wall and the shield and an interior space within the shield, wherein the interior space is in open communication with the lower end of the reactor vessel at its lower end and wherein the exterior space and interior space are fluidly connected by means of one or more openings; and (b) means are present to supply a gas poor in coke precursors to the exterior space.
Abstract translation: 流化催化裂化反应器容器在其上端意味着从稀相流化催化裂化反应器提升管的流出物中分离出催化剂颗粒，该分离装置流体地连接到反应器提升管的下游部分，流体连接到排出装置 清洁的来自容器的反应器提升管流出物并且流体连接到将分离的催化剂排放到容器的下端的装置，该容器还在其下端处意味着从反应器容器排出催化剂，其中（a） 容器的壁和分离装置存在屏蔽，导致容器壁和屏蔽之间的外部空间以及屏蔽内的内部空间，其中内部空间与反应堆的下端开放连通 其下端并且其中外部空间和内部空间通过一个或多个开口流体连接; 和（b）存在的方式是将不利于焦炭前体的气体供应到外部空间。
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公开(公告)号：US20050249147A1
公开(公告)日：2005-11-10
申请号：US10838793
申请日：2004-05-04
Applicant: Brian Fowler
Inventor： Brian Fowler
IPC: H04L12/28 , H04L12/56 , H04W8/26 , H04W60/00 , H04W76/00 , H04W76/02 , H04W76/06 , H04W88/08 , H04W88/14 , H04Q7/00
Abstract: A private exchange telephone system implemented within a wireless router so as to enable wireless devices connected to the router to operate like standard telephones connected to a PBX. The router includes a softswitch that allows the router to operate as the equivalent of a PSTN central office, effectuating a gateway between a packet-switched network and wireless telephony devices, such as PDAs and other types of wireless devices, in communication with the router. The router utilizes flash memory to store and operate the kernel and root file system for the router, as well as a variety of telephony applications, such as voicemail to e-mail conversion, auto-attendant, conferencing, automatic call distribution and caller identification. The router also provides availability for administrative management, roaming extensions, and branch office support for toll bypass and remote employee integration.
Abstract translation: 在无线路由器内部实现的专用交换电话系统，以使连接到路由器的无线设备能够像连接到集团电话的标准电话一样操作。 路由器包括软交换机，其允许路由器作为等同于PSTN中心局的操作，实现与路由器通信的分组交换网络与无线电话设备（例如PDA和其他类型的无线设备）之间的网关。 路由器使用闪存来存储和操作路由器的内核和根文件系统，以及各种电话应用程序，如语音邮件到电子邮件转换，自动话务员，会议，自动呼叫分配和呼叫者识别。 路由器还提供管理管理，漫游扩展和分支机构支持可用于收费旁路和远程员工集成。
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