Abstract:
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract:
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract:
The present invention relates to the prognosis, diagnosis and treatment of cancer, particularly prostate cancer. Polynucleotides having single nucleotide polymorphisms (SNPs) and haplotypes are provided which are of utility in the prognosis, diagnosis, prophylaxis and treatment of prostate and breast cancer.
Abstract:
Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including α-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
Abstract:
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract:
Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract:
Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract:
Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
Abstract:
A seat assembly for a motorcycle includes a rider seat having a forward end and a rearward end, a mounting bracket pivotally coupling the forward end of the rider seat to a frame of a motorcycle, the rider seat being pivotable to raise the rearward end of the seat, and a support arm. The seat assembly further includes a rear seat support having a first end portion and a second end portion, the first end portion being pivotally coupled to the support arm and the second end portion supporting a rear seat. The rear seat support is pivotal from a first position in which the rear seat is hidden from view below the rider seat to a second position in which the rear seat can support a passenger. The seat assembly also includes a stop feature for supporting the second end portion relative to the support arm and a lock feature for inhibiting pivoting of the rear seat support.
Abstract:
A seat assembly for a motorcycle includes a rider seat having a forward end and a rearward end, a mounting bracket pivotally coupling the forward end of the rider seat to a frame of a motorcycle, the rider seat being pivotable to raise the rearward end of the seat, and a support arm. The seat assembly further includes a rear seat support having a first end portion and a second end portion, the first end portion being pivotally coupled to the support arm and the second end portion supporting a rear seat. The rear seat support is pivotal from a first position in which the rear seat is hidden from view below the rider seat to a second position in which the rear seat can support a passenger. The seat assembly also includes a stop feature for supporting the second end portion relative to the support arm and a lock feature for inhibiting pivoting of the rear seat support.