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    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS
    12.
    发明申请
    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS 有权
    用于顺序递送试剂的流体系统

    公开(公告)号：US20100300559A1

    公开(公告)日：2010-12-02

    申请号：US12785667

    申请日：2010-05-24

    Applicant: Jonathan Schultz ,  David Marran

    Inventor： Jonathan Schultz ,  David Marran

    IPC: F16L41/00

    CPC classification number: B01L3/502715 ,  B01J2219/00389 ,  B01J2219/00394 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502769 ,  B01L3/502776 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12Q1/6869 ,  G01N27/447 ,  G01N35/1002 ,  G01N35/1097 ,  Y10T137/0318 ,  Y10T137/0424 ,  Y10T137/85938 ,  C12Q2565/629 ,  C12Q2527/119

    Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions.

    Abstract translation: 本发明提供了一种用于将不同流体引导到公共体积（例如反应室或流动池）的无源流体回路，而不会混合或交叉污染。 通过流体回路的连接点，节点和通道的流动方向和流速由上游阀（例如打开或关闭）的状态，电路入口或上游储存器处的差分流体压力，流动阻力等来控制。 通过所选择的入口流体的流动防止流体从未选择的入口到共同的出口或其他入口处的自由扩散或泄漏，其一部分由未选择的流体的入口扫过并且通过废物端口离开流体回路 ，从而产生阻止与出口流通过泄漏或扩散的不期望的混合的屏障。 本发明在用于进行灵敏多步反应（例如基于pH的DNA测序反应）的装置中特别有利。

    Adjustable hospital gown
    14.
    发明授权
    Adjustable hospital gown 有权

    公开(公告)号：US12256793B2

    公开(公告)日：2025-03-25

    申请号：US17477264

    申请日：2021-09-16

    Applicant: Robert Schultz ,  Jonathan Schultz

    Inventor： Robert Schultz ,  Jonathan Schultz

    IPC: A41D13/12

    Abstract: An adjustable hospital gown is designed to cover the bodies of users of varying shape and size. The gown has a torso-covering garment, a pair of backflaps, and an adjustable fastener. The torso-covering garment is used to cover the front side of the user's body. The pair of backflaps are connected along backflap seams that are positioned on opposite sides of the torso-covering garment. As a result, the pair of backflaps can be transitioned between an opened and a closed configuration. The adjustable fastener is connected in between one of the backflaps and the torso-covering garment such that the backflap can be repositioned to cinch the gown around the body of the user. By connecting the adjustable fastener to various anchor points, the size of the gown can be modified to accommodate user's of varying shape.

    Models for analyzing data from sequencing-by-synthesis operations
    15.
    发明授权
    Models for analyzing data from sequencing-by-synthesis operations 有权

    公开(公告)号：US10146906B2

    公开(公告)日：2018-12-04

    申请号：US13339846

    申请日：2011-12-29

    Applicant: Todd Rearick ,  Jonathan Schultz

    Inventor： Todd Rearick ,  Jonathan Schultz

    IPC: G06F19/24 ,  C12Q1/6869

    Abstract: Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.

    Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
    16.
    发明授权
    Phase-protecting reagent flow orderings for use in sequencing-by-synthesis 有权
    用于逐段合成的相保护试剂流动顺序

    公开(公告)号：US09428807B2

    公开(公告)日：2016-08-30

    申请号：US13440849

    申请日：2012-04-05

    Applicant: Earl Hubbell ,  Jonathan Schultz

    Inventor： Earl Hubbell ,  Jonathan Schultz

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C12Q1/6874 ,  C12Q2533/101 ,  C12Q2565/301 ,  C12Q2565/607

    Abstract: A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering.

    Abstract translation: 用于核酸测序的方法包括在传感器阵列上的限定空间中设置模板多核苷酸链，至少一些模板多核苷酸链具有测序引物和与之可操作地结合的聚合酶; 将模板多核苷酸链暴露于根据预定排序流动的一系列核苷酸类型的流; 并且对于核苷酸种类的每一系列流程，确定针对该特定流出现多少个核苷酸掺入以确定对应于模板多核苷酸链的预测的核苷酸序列，其中预定顺序（a）不是一系列连续的 重复四种不同核苷酸物种的4流置换，（b）不是特定的针对待测序的特定模板多核苷酸链和特定的待测序列的特定组合而定制的，（c） 保护流量顺序。

    System and methods for making and processing emulsions
    18.
    发明授权
    System and methods for making and processing emulsions 有权
    制造和加工乳液的系统和方法

    公开(公告)号：US09017993B2

    公开(公告)日：2015-04-28

    申请号：US13442547

    申请日：2012-04-09

    Applicant: Jonathan Schultz ,  John Nobile ,  Brian Reed ,  Prasanna Thwar ,  Todd Roswech

    Inventor： Jonathan Schultz ,  John Nobile ,  Brian Reed ,  Prasanna Thwar ,  Todd Roswech

    IPC: C12M1/00 ,  C12M3/00 ,  C12M1/34 ,  C12M1/36 ,  C12M1/38 ,  B01F3/08 ,  B01F5/04 ,  B01F13/00 ,  B04B5/04 ,  B04B7/02 ,  B01L3/00

    CPC classification number: B01F5/0602 ,  B01F3/0807 ,  B01F5/0485 ,  B01F13/0059 ,  B01F2215/0037 ,  B01L3/502784 ,  B04B5/0414 ,  B04B7/02

    Abstract: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermocycling subsystem, in automated fashion. The ePCR subsystem can continuously thermocycle an inverse emulsion passed therethrough and includes static temperature zones and a consumable thermocycling plate. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

    Abstract translation: 提供了一种自动化的在线模板珠粒制备系统，包括膜基乳液生成子系统，乳液PCR（ePCR）热循环板和子系统，以及连续离心乳液破乳和模板珠收集子系统。 乳液生成子系统在制备反相乳液时提供均匀性，并可用于快速且可再现地产生大体积或小体积的反相乳液。 提供一种乳液生成装置，其能够以自动方式向逆循环子系统提供连续的反相乳液流。 ePCR子系统可以连续热循环通过的反相乳液，并包括静态温度区和可消耗的热循环板。 连续离心子系统可以连续地破坏热循环的反相乳液并收集形成在反相乳液的微量微反应器液滴中的模板珠粒。

    PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS
    20.
    发明申请
    PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS 有权
    用于按顺序合成使用的相保护试剂流动顺序

    公开(公告)号：US20120264621A1

    公开(公告)日：2012-10-18

    申请号：US13440849

    申请日：2012-04-05

    Applicant: Earl HUBBELL ,  Jonathan SCHULTZ

    Inventor： Earl HUBBELL ,  Jonathan SCHULTZ

    IPC: C40B20/04

    CPC classification number: C12Q1/6869 ,  C12Q1/6874 ,  C12Q2533/101 ,  C12Q2565/301 ,  C12Q2565/607

    Abstract: A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering.

    Abstract translation: 用于核酸测序的方法包括在传感器阵列上的限定空间中设置模板多核苷酸链，至少一些模板多核苷酸链具有测序引物和与之可操作地结合的聚合酶; 将模板多核苷酸链暴露于根据预定排序流动的一系列核苷酸类型的流; 并且对于核苷酸种类的每一系列流程，确定针对该特定流出现多少个核苷酸掺入以确定对应于模板多核苷酸链的预测的核苷酸序列，其中预定顺序（a）不是一系列连续的 重复四种不同核苷酸物种的4流置换，（b）不是特定的针对待测序的特定模板多核苷酸链和特定的待测序列的特定组合而定制的，（c） 保护流量顺序。

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