公开(公告)号：US20120208840A1

公开(公告)日：2012-08-16

申请号：US13498499

申请日：2010-09-28

Applicant: Wenkiu K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha-Bin Im

Inventor： Wenkiu K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha-Bin Im

IPC: A61K31/437 ,  A61K31/4375 ,  C07D215/38 ,  A61K31/47 ,  A61P43/00 ,  A61K31/4709 ,  A61P27/02 ,  A61P9/00 ,  A61P37/08 ,  A61P29/00 ,  C07D471/04 ,  C07D401/12

CPC classification number: C07D471/04 ,  C07D215/38

Abstract: The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.

Abstract translation: 本发明提供由式I表示的化合物，其中每一种化合物可具有鞘氨醇-1-磷酸受体激动剂和/或拮抗剂生物活性，其中这些化合物选自其中A，B，C，D，X， Y，Z和R3在本说明书中定义。 所述化合物可用于治疗选自眼部疾病的哺乳动物的疾病或病症; 全身血管屏障相关疾病; 过敏等炎症疾病; 心脏疾病或病症; 纤维化; 疼痛和伤口。

公开(公告)号：US20120208821A1

公开(公告)日：2012-08-16

申请号：US13500501

申请日：2010-10-06

Applicant: Ken Chow ,  Liming Wang ,  Wenkui K. Fang ,  Evelyn G. Corpuz ,  Santosh C. Sinha ,  Daniel W. Gil ,  Mohammad I. Dibas ,  John E. Donello

Inventor： Ken Chow ,  Liming Wang ,  Wenkui K. Fang ,  Evelyn G. Corpuz ,  Santosh C. Sinha ,  Daniel W. Gil ,  Mohammad I. Dibas ,  John E. Donello

IPC: A61K31/40 ,  C07D403/12 ,  A61K31/4184 ,  C07D401/12 ,  A61K31/435 ,  A61K31/498 ,  A61K31/4709 ,  A61P25/00 ,  A61P17/00 ,  A61P29/00 ,  A61P17/10 ,  A61P17/06 ,  A61P27/06 ,  A61P27/02 ,  C07D207/22

CPC classification number: A61K31/498 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4709 ,  C07D207/22 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  Y10S514/913

Abstract: Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

Abstract translation: 本文描述的化合物可用于通过调节一种或多种α-肾上腺素能受体来治疗疾病和病症。 化合物可以包括萘，喹啉，苯并咪唑或异喹啉作为核心结构。 描述制备，使用和配制这些化合物的方法。

公开(公告)号：US20120183061A1

公开(公告)日：2012-07-19

申请号：US13429611

申请日：2012-03-26

Applicant: Teruhiko Suzuki ,  Liming Wang ,  Yoichi Yagasaki

Inventor： Teruhiko Suzuki ,  Liming Wang ,  Yoichi Yagasaki

IPC: H04N7/32

CPC classification number: H04N19/51 ,  H04N19/37 ,  H04N19/61

Abstract: A decoding apparatus for decoding two encoded field data obtained by hierarchically encoding two field data associated with each of a plurality of picture data composing a moving picture image. The decoding apparatus comprising: a first decoding unit configured to decode one of the two encoded field data and obtain information associated with the two encoded field data; a conversion unit configured to interpolate first predicted image data generated by decoding by the first decoding unit according to the information and generate second predicted image data of a scanning position of the other encoded field data of the two encoded field data; and a second decoding unit configured to decode the other encoded field data of the two encoded field data based on the second predicted image data generated by the conversion unit.

Abstract translation: 一种解码装置，用于对通过对构成运动图像图像的多个图像数据中的每一个相关联的两个场数据进行分层编码获得的两个编码场数据进行解码。 所述解码装置包括：第一解码单元，被配置为对所述两个编码场数据中的一个进行解码并获得与所述两个编码场数据相关联的信息; 转换单元，被配置为根据所述信息内插由所述第一解码单元进行的解码产生的第一预测图像数据，并生成所述两个编码场数据的其他编码场数据的扫描位置的第二预测图像数据; 以及第二解码单元，被配置为基于由转换单元生成的第二预测图像数据来解码两个编码场数据的其他编码场数据。

公开(公告)号：US20120142739A1

公开(公告)日：2012-06-07

申请号：US13294520

申请日：2011-11-11

Applicant: Wenkui K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha Bin Im

Inventor： Wenkui K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha Bin Im

IPC: A61K31/4439 ,  C07D413/14 ,  A61P27/02 ,  A61P9/10 ,  A61P29/00 ,  A61P11/00 ,  A61P35/04 ,  A61P37/06 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00 ,  A61P17/06 ,  A61P13/12 ,  A61P17/00 ,  A61P37/08 ,  A61P11/06 ,  A61P31/12 ,  A61P17/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/28 ,  C07D413/04

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract translation: 本发明涉及新的恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

公开(公告)号：US20120142642A1

公开(公告)日：2012-06-07

申请号：US13300805

申请日：2011-11-21

Applicant: Wenkui K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha-Bin Im

Inventor： Wenkui K. Fang ,  Liming Wang ,  Evelyn G. Corpuz ,  Ken Chow ,  Wha-Bin Im

IPC: A61K31/195 ,  C07F9/38 ,  A61K31/662 ,  C07C321/28 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P11/00 ,  A61P37/00 ,  A61P35/04 ,  A61P9/10 ,  A61P7/10 ,  A61P37/06 ,  A61P1/00 ,  A61P5/16 ,  A61P25/00 ,  A61P21/04 ,  A61P17/06 ,  A61P1/04 ,  A61P17/00 ,  A61P37/08 ,  A61P11/06 ,  A61P9/00 ,  A61P17/02 ,  A61P19/00 ,  A61P19/10 ,  C07C251/40

CPC classification number: C07F9/3834 ,  C07C229/34 ,  C07F9/3808

Abstract: The present invention relates to novel oxime derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract translation: 本发明涉及新颖的肟衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

公开(公告)号：US08144765B2

公开(公告)日：2012-03-27

申请号：US12063713

申请日：2006-08-17

Applicant: Teruhiko Suzuki ,  Liming Wang ,  Yoichi Yagasaki

Inventor： Teruhiko Suzuki ,  Liming Wang ,  Yoichi Yagasaki

IPC: H04N7/12

CPC classification number: H04N19/51 ,  H04N19/37 ,  H04N19/61

Abstract: A coding apparatus for hierarchically (layering) coding top field data and bottom field data divided from each of a plurality of picture data composing a moving picture image has a first coding unit (12) configured to encode one field data between two field data of the top field data and the bottom field data divided from the picture data, a conversion unit (13) configured to interpolate first predicted image data generated by the first coding unit encoding above one field data and generate a second predicted image data of a scanning position of the other field data between the two field data, and a second coding unit (14) configured to encode the other field data between the two field data based on the second predicted image data generated by the conversion unit.

Abstract translation: 一种编码装置，用于对从构成运动图像图像的多个图像数据中的每一个划分的顶场数据和底场数据进行分层编码（分层）编码，具有第一编码单元（12），其被配置为对一个场数据进行编码， 顶视场数据和从图像数据分割的底场数据，转换单元（13），其被配置为内插由第一编码单元生成的第一预测图像数据，编码在一个场数据之上，并生成第二预测图像数据的扫描位置 两个场数据之间的其他场数据和第二编码单元（14），被配置为基于由转换单元生成的第二预测图像数据对两场数据之间的其他场数据进行编码。

公开(公告)号：US08105848B2

公开(公告)日：2012-01-31

申请号：US12900826

申请日：2010-10-08

Applicant: Xing Su ,  Kenneth Schwartz ,  Liming Wang ,  David Schwartz ,  Mineo Yamakawa

Inventor： Xing Su ,  Kenneth Schwartz ,  Liming Wang ,  David Schwartz ,  Mineo Yamakawa

IPC: G01N33/53

CPC classification number: G01N1/4044 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0638 ,  B01L2400/086 ,  G01N35/0098 ,  G01N35/08 ,  G01N2015/0038 ,  G01N2015/0092 ,  H01F7/20 ,  H01F7/206 ,  H01F2007/068 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T29/49117 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T436/25

Abstract: An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.

Abstract translation: 本发明的实施例涉及一种装置，包括（1）包括线圈，金属芯和金属芯头的电磁元件阵列，以及（2）适于一个或多个线圈分别控制电流的控制器， 单独地改变所述一个或多个线圈的电流，以单独地反转一个或多个线圈的电流，并且跨越两个或更多个线圈产生特定的磁通分布和梯度; 其中所述金属芯头位于所述线圈的一端，并且所述金属芯头具有几何形状以在两个相邻线圈之间的感兴趣区域中产生期望的磁通量，强度和梯度; 其中所述装置在功能上耦合到流体装置以将流体中的磁性颗粒集中并输送到流体中而不流体流动。

公开(公告)号：US08080570B2

公开(公告)日：2011-12-20

申请号：US12433953

申请日：2009-05-01

Applicant: Janet A. Takeuchi ,  Ken Chow ,  Ling Li ,  Liming Wang

Inventor： Janet A. Takeuchi ,  Ken Chow ,  Ling Li ,  Liming Wang

IPC: A01N43/76 ,  A61K31/42 ,  C07D413/00 ,  C07D263/00

CPC classification number: A61K31/421 ,  C07D263/28

Abstract: Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2B and α2C adrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.

Abstract translation: 本文描述的是可用作生物活性剂的化合物。 更具体地，本文所述的化合物可用作α2B和α2C肾上腺素能激动剂。 还公开了化合物的合成和给药方法。

公开(公告)号：US20110268391A1

公开(公告)日：2011-11-03

申请号：US12925304

申请日：2010-10-19

Applicant: Buck Wang ,  Liming Wang

Inventor： Buck Wang ,  Liming Wang

IPC: G02B6/36

CPC classification number: G02B6/00 ,  B82Y20/00 ,  G02B6/0008 ,  G02B6/3825 ,  G02B6/3897 ,  G02B6/4292

Abstract: The present invention discloses an optical fiber connection device, comprising: a base plate; at least one adapter for receiving optical fiber connectors; a rotating and fixing mechanism being provided on the base plate and being connected with the adapters, the rotating and fixing mechanism comprising: a fixing portion for fixedly connecting with the adapter; and a rotating portion being rotatably connected to the base plate, through which the mechanism can rotate between an operation position and a receiving/releasing position; and a positioning member for stably holding the rotating and fixing mechanism in the operation position or the receiving/releasing position, and limiting the rotation angle of the mechanism and that of the adapter within a predetermined angle range.

Abstract translation: 本发明公开了一种光纤连接装置，包括：基板; 用于接收光纤连接器的至少一个适配器; 旋转和固定机构设置在基板上并与适配器连接，旋转和固定机构包括：用于与适配器固定连接的固定部分; 以及旋转部分，其可旋转地连接到所述基板，所述机构可以通过所述旋转部分在操作位置和接收/释放位置之间旋转; 以及用于将旋转和固定机构稳定地保持在操作位置或接收/释放位置的定位构件，并将机构的旋转角度和适配器的旋转角度限制在预定角度范围内。

公开(公告)号：US20100297392A1

公开(公告)日：2010-11-25

申请号：US12470595

申请日：2009-05-22

Applicant: Jonathan Chen ,  Timothy Michael Gross ,  David Alan Tammaro ,  Liming Wang

Inventor： Jonathan Chen ,  Timothy Michael Gross ,  David Alan Tammaro ,  Liming Wang

IPC: B32B17/06 ,  B05D5/02

CPC classification number: B65D85/48 ,  B32B17/065 ,  B32B2255/12 ,  B65G49/069 ,  C03C17/002 ,  C03C17/006 ,  C03C17/28 ,  C03C19/00 ,  C03C2217/20 ,  C03C2217/40 ,  C03C2217/775 ,  C03C2217/78 ,  C03C2218/10 ,  C03C2218/11 ,  C03C2218/30 ,  C03C2218/355 ,  C03C2218/365 ,  Y10T428/24355 ,  Y10T428/24926 ,  Y10T428/273

Abstract: This disclosure features use of a paper or polymer film that includes a slip agent that can transfer to its surfaces. Once the paper or film is pressed against a glass sheet, this will leave a thin surface roughness of slip agent that can prevent or reduce glass surface scratches from other surfaces or particles during shipping or finishing (e.g., cutting to size, conveyance of glass), thereby improving the yield of glass shipments between glass forming plants and customers. The thin discontinuous layer of slip agent remaining on the glass surface can be washed off easily in subsequent washing processes. The paper or film can have the slip agent imbibed within the paper or coated on it as a surface member.

Abstract translation: 该公开内容特征在于使用纸或聚合物膜，其包括可以转移到其表面的滑爽剂。 一旦纸张或胶片被压在玻璃板上，这将留下滑爽剂的薄的表面粗糙度，可以防止或减少在运输或整理期间其他表面或颗粒的玻璃表面划痕（例如，切割成尺寸，输送玻璃） ，从而提高玻璃成型厂和客户之间的玻璃出货量。 保留在玻璃表面上的薄的不连续的滑爽剂层可以在随后的洗涤过程中容易地洗掉。 纸或薄膜可以使滑动剂吸收在纸内或涂覆在其上作为表面构件。