专利检索 ap:"Nathan Brammeier" 第 2 页

11.

发明申请
SUBSTITUTED IMIDAZOLE DERIVATIVES 有权
标题翻译：取代的咪唑衍生物

公开(公告)号：US20130017196A1

公开(公告)日：2013-01-17

申请号：US13613977

申请日：2012-09-13

申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le

IPC分类号： A61K31/4174 , C07D401/12 , A61K31/454 , C07D403/12 , A61K31/496 , A61K31/4439 , C07D405/12 , A61K31/4178 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , A61K31/5377 , C07D498/10 , A61P35/00 , A61K31/4745 , A61K31/7068 , A61K39/395 , A61K33/24 , A61K31/664 , A61P35/02 , C07D233/64

CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10

摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。本发明的化合物具有以下通式：

12.

发明申请
2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones 审中-公开
标题翻译： 2-氨基-7,8-二氢-6H-吡啶并[4,3-D]嘧啶-5-酮

公开(公告)号：US20100004237A1

公开(公告)日：2010-01-07

申请号：US12462302

申请日：2009-07-31

申请人： Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe

发明人： Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe

IPC分类号： C07D471/04 , A61K31/5377 , A61K31/497 , A61K31/519

CPC分类号： C07D211/86 , C07D471/04

摘要： Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.

摘要翻译： 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物，其立体异构体，互变异构体，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物，单独或与至少一种额外的治疗剂。还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法，用于预防或治疗细胞增殖，病毒，自身免疫，心血管和中枢神经系统疾病。

13.

发明授权
Thiosemicarbazones as anti-virals and immunopotentiators 失效
标题翻译：硫代氨基脲作为抗病毒剂和免疫增强剂

公开(公告)号：US07521062B2

公开(公告)日：2009-04-21

申请号：US10748071

申请日：2003-12-29

申请人： Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner

发明人： Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner

IPC分类号： A61K39/00 , A61K31/40 , A61K31/44 , A61K31/175 , A61K39/095 , A61K45/00

CPC分类号： C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00

摘要： The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.

摘要翻译： 本发明涉及新型免疫增强剂，新型疫苗佐剂，新化合物和药物组合物，通过施用化合物治疗病毒感染（包括HCV）的新方法，以及通过施用化合物调节免疫应答的新方法。

14.

发明申请
Tetrahydrocarboline compounds as anticancer agents 失效
标题翻译：四氢咔啉化合物作为抗癌剂

公开(公告)号：US20050215580A1

公开(公告)日：2005-09-29

申请号：US11042474

申请日：2005-01-24

申请人： Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng

发明人： Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng

IPC分类号： A61K31/4745 , C07D471/02 , C07D471/04

CPC分类号： C07D471/04

摘要： Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

摘要翻译： 四氢咔啉化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物，单独或与至少一种另外的治疗剂组合。单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。