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    Multilayer enzyme electrode membranes and methods of making same
    13.
    发明授权
    Multilayer enzyme electrode membranes and methods of making same 失效
    多层酶电极膜及其制备方法

    公开(公告)号：US5696314A

    公开(公告)日：1997-12-09

    申请号：US679089

    申请日：1996-07-12

    Applicant: Robert McCaffrey ,  Bonnie Dalzell ,  Katarina Tkacik ,  Susan Holbert ,  Mark Boden ,  James Flaherty ,  Michael Flanagan ,  Josef Brown ,  Kimiya Takeshita ,  Peter Edelman

    Inventor： Robert McCaffrey ,  Bonnie Dalzell ,  Katarina Tkacik ,  Susan Holbert ,  Mark Boden ,  James Flaherty ,  Michael Flanagan ,  Josef Brown ,  Kimiya Takeshita ,  Peter Edelman

    IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/26 ,  G01N33/535 ,  G01N33/66 ,  H01L29/78

    CPC classification number: C12Q1/002 ,  Y10S435/817

    Abstract: An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed. The sensor provides an electrical current output proportional to the reagent chemical interaction of the analyte with an immobilized enzyme layer during exposure of the sensor in such solution.

    Abstract translation: 电化学传感器设计用于检测样品溶液中分析物的浓度。 该传感器具有更长的使用寿命，提高了单个或多个使用应用的稳定性和改进的响应时间。 在一个方面，通过提供具有无孔和多孔层的多层酶电极膜来实现这些目标中的一些。 微孔层由聚合物粘合剂，聚合物粉末，表面活性剂和矿物粉末形成。 在另一方面，这些目标中的某些通过使用由置于聚合物基质内的酶构成的层来实现。 在某些实施方案中，多层酶电极膜包括能够溶解在样品溶液中的最外层，使得多层酶电极膜和样品溶液之间的界面不断更新。 传感器在这种溶液中曝光期间，传感器提供与分析物与固定化酶层的试剂化学相互作用成比例的电流输出。

    MEDICAL DEVICES HAVING A COATING OF BIOLOGIC MACROMOLECULES
    15.
    发明申请
    MEDICAL DEVICES HAVING A COATING OF BIOLOGIC MACROMOLECULES 有权
    具有生物大分子涂层的医疗装置

    公开(公告)号：US20100226953A1

    公开(公告)日：2010-09-09

    申请号：US12708993

    申请日：2010-02-19

    Applicant: Peter EDELMAN

    Inventor： Peter EDELMAN

    IPC: A61F2/00 ,  A61K39/395 ,  B05D1/00 ,  A61P9/00

    CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16

    Abstract: A medical device having a coating of biologic macromolecules. The coating of biologic macromolecules is protected by a temporary protective layer disposed over the biologic macromolecules. The temporary protective layer serves to protect the structure (e.g., conformation) and/or function (e.g., target binding capacity) of the biologic macromolecules during processing, storage, handling, and/or delivery (e.g., implantation or insertion into a patient) of the medical device. Upon implantation or insertion into a patient's body, the temporary protective layer may dissolve to expose the biologic macromolecules to the physiologic environment.

    Abstract translation: 具有生物大分子涂层的医疗装置。 生物大分子的涂层由位于生物大分子上的临时保护层保护。 临时保护层用于在处理，储存，处理和/或递送期间保护生物大分子的结构（例如，构象）和/或功能（例如，靶结合能力）（例如，植入或插入患者体内） 的医疗器械。 在植入或插入患者体内时，临时保护层可以溶解以将生物大分子暴露于生理环境。

    Method for controlling the power consumption of a hydrodynamic clutch by controlling the volumetric efficiency and a hydrodynamic clutch
    18.
    发明授权
    Method for controlling the power consumption of a hydrodynamic clutch by controlling the volumetric efficiency and a hydrodynamic clutch 失效
    通过控制体积效率和流体动力学离合器来控制流体动力离合器的功率消耗的方法

    公开(公告)号：US06910330B2

    公开(公告)日：2005-06-28

    申请号：US10363335

    申请日：2001-08-29

    Applicant: Werner Klement ,  Klaus Vogelsang ,  Peter Edelman ,  Heinz Höller ,  Jürgen Friedrich

    Inventor： Werner Klement ,  Klaus Vogelsang ,  Peter Edelman ,  Heinz Höller ,  Jürgen Friedrich

    IPC: F16H61/64 ,  F16D33/06 ,  F16D33/16

    CPC classification number: F16D33/16 ,  Y10T477/6333

    Abstract: A method for controlling the power consumption of a starting element (1) in the form of a hydrodynamic clutch (2). The clutch comprises an impeller (4) and a turbine wheel (5), which together form at least one toroidal working chamber (6) that can be filled with an operating medium, and is located in a drive train (3) with at least one other drive motor that can be coupled to the hydrodynamic clutch. The method is characterized in that the power consumption can be freely adjusted as a function of the volumetric efficiency of the hydrodynamic clutch and the method has the following characteristics: the supply or evacuation of the operating medium to or from the working chamber is influenced by the generation and introduction of a static superposition pressure in the closed rotating circuit; the operating medium is supplied or evacuated to or from the working chamber by the application of a superposition or influencing pressure to the operating medium level in the operating medium reservoir (40).

    Abstract translation: 一种用于控制液力离合器（2）形式的起动元件（1）的功率消耗的方法。 离合器包括叶轮（4）和涡轮机叶轮（5），它们一起形成至少一个能够填充有操作介质的环形工作室（6），并且至少位于传动系（3）中 另一个驱动马达可以联接到流体动力离合器。 该方法的特征在于，能够根据流体动力离合器的体积效率自由调节功率消耗，该方法具有以下特征：向或从工作室供给或排出操作介质受到 在闭合旋转电路中产生和引入静态叠加压力; 操作介质通过对操作介质储存器（40）中的操作介质水平施加叠加或影响的压力而被供给或抽空到工作室。

    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation
    19.
    发明授权
    Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation 有权

    公开(公告)号：US09597435B2

    公开(公告)日：2017-03-21

    申请号：US12434856

    申请日：2009-05-04

    Applicant: Peter Edelman ,  Afsar Ali

    Inventor： Peter Edelman ,  Afsar Ali

    IPC: A61F2/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16

    CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    Abstract: Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.

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