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    Materials and reactor systems having humidity and gas control
    12.
    发明申请
    Materials and reactor systems having humidity and gas control 审中-公开
    具有湿度和气体控制的材料和反应堆系统

    公开(公告)号：US20070037244A1

    公开(公告)日：2007-02-15

    申请号：US11584149

    申请日：2006-10-20

    Applicant: Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    Inventor： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    IPC: C12Q1/02

    CPC classification number: C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

    Abstract: The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

    Abstract translation: 本发明涉及具有湿气和/或气体控制的材料和反应器系统。 该材料可能具有高的透氧性和/或低水蒸气渗透性。 在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。 在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。 在某些情况下，材料也可以是多孔的和/或透明的。 在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。 在一些情况下，材料可以包括两层或更多层。 每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。 在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。

    Apparatus and method for manipulating substrates
    14.
    发明申请
    Apparatus and method for manipulating substrates 失效
    用于操纵基板的装置和方法

    公开(公告)号：US20050019904A1

    公开(公告)日：2005-01-27

    申请号：US10863584

    申请日：2004-06-07

    Applicant: Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    Inventor： Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    IPC: B01F9/00 ,  B01F11/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12N15/82 ,  C12N15/87

    CPC classification number: C12M23/08 ,  B01F9/0001 ,  B01F9/002 ,  B01F11/00 ,  B01L7/00 ,  B01L9/52 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2400/0409 ,  C12M23/10 ,  C12M23/48 ,  C12M27/10 ,  C12M41/14 ,  Y10S435/809

    Abstract: This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.

    Abstract translation: 本公开总体上涉及用于在诸如培养箱的单元内操作用于化学，生物或生化样品（例如细胞培养物和其它室）的室和其它底物的系统和方法。 在某些实施例中，本发明提供了一种用于将多个基板或腔室保持在壳体内的技术，在壳体内保持预定环境，不同于壳体外部的环境，以及将基板或腔室移入和移出壳体， 一些情况下，在外壳中不会形成大的开口（例如，通过打开比基板大得多的门）。 在某些实施例中提供了一种技术，其中多个基板在壳体内以固定的，固定的关系安装在提供预定的受控环境的壳体内，并且在壳体内移动，使得它们可以均匀地暴露于任何 房屋环境差异。 在某些实施例中，本发明提供了一种用于在一个或多个腔室内的流体搅拌的技术，其可以在某些实施例中提供环境控制，而不用物理地搅拌流体，例如直接用搅拌棒或其它搅拌元件 与流体接触。 在另一个实施例中，本发明提供了一种用于围绕基本垂直和/或水平轴线旋转衬底或室的方法。 在一些情况下，任何上述系统可以以足以使物质在室或衬底内分离的速度旋转。

    Computerized factorial experimental design and control of reaction sites and arrays thereof
    15.
    发明申请
    Computerized factorial experimental design and control of reaction sites and arrays thereof 审中-公开
    计算机化因子实验设计和控制反应位点及其阵列

    公开(公告)号：US20070048863A1

    公开(公告)日：2007-03-01

    申请号：US11492445

    申请日：2006-07-25

    Applicant: Seth Rodgers ,  Fan Zhang ,  Mohamed Shaheen ,  Benjamin Alexander

    Inventor： Seth Rodgers ,  Fan Zhang ,  Mohamed Shaheen ,  Benjamin Alexander

    IPC: C12N5/06 ,  G06F19/00

    CPC classification number: C12M41/48 ,  G16B50/00

    Abstract: Computer-facilitated design of large-scale, multi-factorial cell culture experiments and the like, and control of reaction sites and/or arrays of reaction sites to perform such experiments using automated devices. In certain cases, the invention is directed to controlling a plurality of cell culture experiments, e.g., using an automated cell culture device. In one set of embodiments, a data structure or a “descriptor” for use with cell culture experiments is provided. The descriptor may be used, for instance, to control one or more cell culture experiments, to identify one or more cell culture experiments, and/or to identify or “tag” data arising from one or more cell culture experiments, e.g., for further analysis or recall.

    Abstract translation: 大规模，多因素细胞培养实验等的计算机辅助设计，以及反应位点和/或反应位点阵列的控制，以使用自动化装置进行这种实验。 在某些情况下，本发明涉及控制多种细胞培养实验，例如使用自动细胞培养装置。 在一组实施例中，提供了用于细胞培养实验的数据结构或“描述符”。 描述符可以用于例如控制一个或多个细胞培养实验，以鉴定一个或多个细胞培养实验，和/或识别或“标记”由一个或多个细胞培养实验产生的数据，例如进一步 分析或召回。

    Fluid transfer device
    16.
    发明申请
    Fluid transfer device 审中-公开
    流体输送装置

    公开(公告)号：US20070015276A1

    公开(公告)日：2007-01-18

    申请号：US11474050

    申请日：2006-06-23

    Applicant: Sean LeBlanc ,  Ian MacGregor ,  Bernardo Aumond ,  George Vella ,  A. Russo ,  Seth Rodgers ,  Andrey Zarur

    Inventor： Sean LeBlanc ,  Ian MacGregor ,  Bernardo Aumond ,  George Vella ,  A. Russo ,  Seth Rodgers ,  Andrey Zarur

    IPC: C12M3/00 ,  A61M31/00

    CPC classification number: B01L3/0275 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681

    Abstract: Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 μL) with a high degree of accuracy.

    Abstract translation: 本文所述的流体输送装置可以包括主体部分和尖端部分。 流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。 在一些实施例中，流体输送装置用接合元件连接到流体分配装置。 接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。 身体能够存储从分配装置接收的流体。 尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。 有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如，1μl）。

    Control of reactor environmental conditions
    17.
    发明申请
    Control of reactor environmental conditions 审中-公开
    控制反应堆环境条件

    公开(公告)号：US20060019333A1

    公开(公告)日：2006-01-26

    申请号：US11146920

    申请日：2005-06-07

    Applicant: Seth Rodgers ,  A. Russo ,  Sean LeBlanc ,  Denis Leroux

    Inventor： Seth Rodgers ,  A. Russo ,  Sean LeBlanc ,  Denis Leroux

    IPC: C12P1/00

    CPC classification number: B01D61/002 ,  B01J19/0093 ,  B01J2219/00317 ,  B01J2219/00743 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/10 ,  B01L2300/12 ,  B01L2300/163 ,  B01L2300/1822 ,  B01L2400/046 ,  C12P1/00 ,  C40B60/14

    Abstract: The present disclosure generally relates to chemical, biological, and/or biochemical reactor chips and/or reaction systems such as microreactor systems, as well as methods for constructing and using such systems. In some cases, humidity control materials are utilized to provide beneficially high rates of gas exchange. The humidity control materials may be used, in certain instances, to provide at least adequate, and in certain embodiments superior, gas exchange for systems having small volumes. In some cases, the currently disclosed materials include certain polymers, e.g., poly(acetylene)s such as poly(alkylacetylene)s. The polymers may be at least partially halogenated (for example, fluorinated) in some instances. In certain embodiments, a chip and/or a reaction system may be constructed so as to promote cell growth within it. In some embodiments, the chips may include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In certain embodiments, a reaction system is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc., associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In certain embodiments, the present disclosure discloses materials and systems having humidity and/or gas control, for example, for use with a reaction system. Such materials may have high oxygen permeability and/or low water vapor permeability. In certain embodiments, the disclosed devices can employ light-interacting components suitable for use in reaction systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本公开一般涉及化学，生物和/或生化反应堆芯片和/或反应系统，例如微反应器系统，以及用于构建和使用这种系统的方法。 在一些情况下，使用湿度控制材料来提供有利的高比例的气体交换。 在某些情况下，可以使用湿度控制材料，以在具有小体积的系统中提供至少足够的且在某些实施方案中优异的气体交换。 在一些情况下，目前公开的材料包括某些聚合物，例如聚（乙炔）如聚（烷基乙炔）。 在某些情况下，聚合物可以至少部分卤化（例如氟化）。 在某些实施方案中，可以构建芯片和/或反应系统以促进细胞内的细胞生长。 在一些实施方案中，芯片可以包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在某些实施方案中，反应体系能够检测，测量和/或控制环境因素，例如温度，压力，CO 2浓度，O 2 O 2浓度，相对 通过使用一个或多个传感器，致动器，处理器和/或控制系统与一个或多个反应位点相关的湿度，湿度，pH等。 在某些实施方案中，本公开公开了具有例如用于反应体系的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在某些实施方案中，所公开的装置可以使用适合用于反应体系的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

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