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    Spin filter junction and method of fabricating the same
    11.
    发明申请
    Spin filter junction and method of fabricating the same 审中-公开
    自旋滤波器结及其制造方法

    公开(公告)号：US20110063758A1

    公开(公告)日：2011-03-17

    申请号：US12925632

    申请日：2010-10-26

    Applicant: Shan X. Wang ,  George Michael Chapline

    Inventor： Shan X. Wang ,  George Michael Chapline

    IPC: G11B5/33

    CPC classification number: H01L29/66984 ,  B82Y25/00 ,  H01L43/08

    Abstract: A magnetic tunnel junction having a first electrode separated from a second electrode by a tunneling barrier is provided. The tunneling barrier is a ferromagnetic insulator that provides a spin dependent barrier energy for tunneling. The first electrode includes a ferromagnetic, electrically conductive layer. Electrons emitted from the first electrode toward the tunneling barrier are partially or completely spin-polarized according to the magnetization of the ferromagnetic electrode layer. The electrical resistance of the tunnel junction depends on the relative orientation of the electrode layer magnetization and the tunneling barrier magnetization. Such tunnel junctions are widely applicable to spintronic devices, such as spin valves, magnetic tunnel junctions, spin switches, spin valve transistors, spin filters, and to spintronic applications such as magnetic recording, magnetic random access memory, ultrasensitive magnetic field sensing (including magnetic biosensing), spin injection and spin detection.

    Abstract translation: 提供了具有通过隧道势垒从第二电极分离的第一电极的磁性隧道结。 隧道势垒是铁磁绝缘体，其提供用于隧穿的自旋相关势垒能。 第一电极包括铁磁性导电层。 从第一电极向隧道势垒发射的电子根据铁磁性电极层的磁化而部分或完全自旋极化。 隧道结的电阻取决于电极层磁化和隧道势垒磁化的相对取向。 这种隧道结广泛适用于自旋阀，自旋阀，磁隧道结，自旋开关，自旋阀晶体管，自旋过滤器等自旋电子器件，以及磁记录，磁性随机存取存储器，超磁场感应（包括磁性） 生物传感），自旋注射和自旋检测。

    Biomolecule Immobilization on Biosensors
    13.
    发明申请
    Biomolecule Immobilization on Biosensors 有权
    生物传感器上的生物分子固定

    公开(公告)号：US20080161200A1

    公开(公告)日：2008-07-03

    申请号：US11949442

    申请日：2007-12-03

    Applicant: Heng Yu ,  Nader Pourmand ,  Shan X. Wang

    Inventor： Heng Yu ,  Nader Pourmand ,  Shan X. Wang

    IPC: C40B40/00 ,  C40B50/18

    CPC classification number: C40B60/12 ,  C40B40/08 ,  C40B40/10 ,  C40B50/18 ,  G01N33/54353

    Abstract: A highly specific and versatile surface chemistry for immobilization of amine-terminated probes is disclosed. A bi-layered polymer thin film serves as the platform for coupling the probes, which are preferably oligonucleotides. The process involves sequentially coating a substrate with polyamine and polyacid anhydride. Hydrolyzed polyacid anhydride groups may be converted to non-hydrolyzed groups at about 100° C. prior to probe attachment. The process of coating the substrate requires no harsh chemical pretreatment of substrates such as RCA or Piranha cleaning. In addition, simple thermal activation of the anhydride groups has a low requirement for storage, leading to a long shelf life of modified surfaces. The disclosed surface chemistry is especially compatible with microfabrication processes, and its effective application to magnetic biosensors is demonstrated.

    Abstract translation: 公开了用于固定胺封端的探针的高度特异性和多功能的表面化学。 双层聚合物薄膜用作耦合探针的平台，优选为寡核苷酸。 该方法包括依次用多胺和多酸酐涂覆底物。 在探针附着之前，水解的多酸酐基团可以在约100℃下转化为非水解基团。 涂覆基材的过程不需要对基材进行苛刻的化学预处理，例如RCA或Piranha清洗。 此外，酸酐基团的简单热活化对储存的要求较低，导致改性表面的保质期长。 所公开的表面化学特性与微细加工工艺特别兼容，并且证明了其在磁性生物传感器中的有效应用。

    Directly fabricated nanoparticles for raman scattering
    15.
    发明授权
    Directly fabricated nanoparticles for raman scattering 失效
    用于拉曼散射的直接制造的纳米颗粒

    公开(公告)号：US08568878B2

    公开(公告)日：2013-10-29

    申请号：US13066248

    申请日：2011-04-08

    Applicant: Robert J. Wilson ,  Jung-Sub Wi ,  Shan X. Wang ,  Edward S. Barnard ,  Mark L. Brongersma ,  Mary Tang

    Inventor： Robert J. Wilson ,  Jung-Sub Wi ,  Shan X. Wang ,  Edward S. Barnard ,  Mark L. Brongersma ,  Mary Tang

    IPC: B22F1/00 ,  G01N21/65

    CPC classification number: B22F1/0018 ,  B22F7/08 ,  B22F2001/0037 ,  B82Y30/00

    Abstract: A Raman-active nanoparticle is provided that includes a dish-shape plasmonically active metal base, and a plasmonically active metal pillar disposed on the plasmonically active metal base, where the plasmonically active metal pillar is disposed within the dish-shape plasmonically active metal base and normal to a bottom of the dish-shape plasmonically active metal base, where a circular gap is disposed between the dish-shape plasmonically active metal pillar and inner walls of the dish-shape plasmonically active metal base. In one embodiment a Raman-active nanoparticle is provided that includes a dish-shape base having a dielectric material, an electrically conductive layer disposed on the inner surface of the dish-shape base, and an electrically conductive pillar disposed on the conductive layer, and within the dish-shape and perpendicular to a bottom of the dish-shape base, where a circular gap is disposed between the conductive pillar and inner walls of the dish-shape base.

    Abstract translation: 提供了一种拉曼活性纳米颗粒，其包括盘状等离子体活性金属碱和设置在等离子体活性金属基体上的等离子体活性金属柱，其中等离子体活性金属柱设置在盘状等离子体活性金属基质内， 垂直于盘形等离子体活性金属基底的底部，其中盘形等离子体活性金属柱和盘形等离子体活性金属基底的内壁之间设置有圆形间隙。 在一个实施方案中，提供了拉曼活性纳米颗粒，其包括具有介电材料的盘形基底，设置在盘形基底的内表面上的导电层和设置在导电层上的导电柱，以及 在碟形基底中的垂直于盘形基底的底部，其中圆形间隙设置在盘形基底的导电柱和内壁之间。

    Magnetic sensor array having an analog frequency-division multiplexed output
    18.
    发明授权
    Magnetic sensor array having an analog frequency-division multiplexed output 有权
    具有模拟频分复用输出的磁传感器阵列

    公开(公告)号：US07939338B2

    公开(公告)日：2011-05-10

    申请号：US11128105

    申请日：2005-05-11

    Applicant: Shan X. Wang ,  Shu-Jen Han

    Inventor： Shan X. Wang ,  Shu-Jen Han

    IPC: G01R33/00

    CPC classification number: G01R33/09 ,  B82Y25/00 ,  G01N33/5438 ,  G01R33/093 ,  G01R33/12 ,  G01R33/1269 ,  Y10T436/13

    Abstract: A magnetic sensor array including magnetoresistive sensor elements having outputs combined by frequency division multiplexing (FDM) is provided. Each sensor element provides an input to a mixer which provides a distinct frequency shift. Preferably, time division multiplexing is also used to combine sensor element outputs. Each sensor element is typically in proximity to a corresponding sample. The sensor elements are preferably subarrays having row and column addressable sensor element pixels. This arrangement provides multiple sensor pixels for each sample under test. Multiplexing of sensor element outputs advantageously reduces readout time. A modulated external magnetic field is preferably applied during operation, to reduce the effect of 1/f noise on the sensor element signals. The effect of electromagnetic interference (EMI) induced by the magnetic field on sensor element signals is advantageously reduced by the mixing required for FDM.

    Abstract translation: 提供了包括具有通过频分复用（FDM）组合的输出的磁阻传感器元件的磁传感器阵列。 每个传感器元件为混频器提供输入，该混频器提供不同的频移。 优选地，时分复用也用于组合传感器元件输出。 每个传感器元件通常接近相应的样品。 传感器元件优选地是具有行和列可寻址传感器元件像素的子阵列。 这种布置为每个待测样品提供了多个传感器像素。 传感器元件输出的多路复用有利于减少读出时间。 在操作期间优选地施加调制的外部磁场，以减少1 / f噪声对传感器元件信号的影响。 通过FDM所需的混合有利地减少了由磁场引起的电磁干扰（EMI）对传感器元件信号的影响。

    METHODS AND DEVICES FOR DETECTING THE PRESENCE OF AN ANALYTE IN A SAMPLE
    19.
    发明申请
    METHODS AND DEVICES FOR DETECTING THE PRESENCE OF AN ANALYTE IN A SAMPLE 有权
    用于检测样品中分析物存在的方法和装置

    公开(公告)号：US20110027901A1

    公开(公告)日：2011-02-03

    申请号：US12759584

    申请日：2010-04-13

    Applicant: Richard Samuel Gaster ,  Drew Hall ,  Shan X. Wang

    Inventor： Richard Samuel Gaster ,  Drew Hall ,  Shan X. Wang

    IPC: G01N27/72 ,  G01N21/75 ,  G01N1/00 ,  G01N33/48

    CPC classification number: G01N33/54373 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/658 ,  G01N27/745 ,  G01N33/574 ,  G01N2201/0221 ,  Y10T436/25

    Abstract: Sensor assay methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include providing a sensor, e.g., a proximity sensor, in contact with an assay composition that includes a sample and a proximity label. Next, a capture probe configured to bind to the proximity label and the analyte is introduced into the assay composition to produce a labeled analyte. Following capture probe introduction, a signal is obtained from the sensor to detect the presence of the labeled analyte in the sample. Also provided are sensor devices, including hand-held devices, and kits that find use in practicing the subject methods.

    Abstract translation: 提供了用于检测样品中分析物的存在的传感器测定方法。 方法的方面包括提供与包括样品和接近标签的测定组合物接触的传感器，例如接近传感器。 接下来，将配置成与邻近标签和分析物结合的捕获探针引入测定组合物中以产生标记的分析物。 在捕获探针引入后，从传感器获得信号以检测样品中标记分析物的存在。 还提供了用于实践主题方法的传感器装置，包括手持装置和试剂盒。

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