公开(公告)号：US20080075833A1

公开(公告)日：2008-03-27

申请号：US11998091

申请日：2007-11-27

Applicant: Stephen Pacetti

Inventor： Stephen Pacetti

IPC: A61L31/08 ,  A61F2/82 ,  B05D3/00 ,  C08F14/26 ,  C08F20/06 ,  C08F210/16 ,  C08F218/02

CPC classification number: A61L27/34 ,  A61F2/82 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  B05D7/586 ,  C08L53/02 ,  C08L53/025 ,  C09D129/04 ,  C09D153/02 ,  C09D153/025 ,  Y10T428/1355 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24942 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31678 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L2666/02

Abstract: A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.

Abstract translation: 公开了一种降低治疗物质从可植入医疗装置（例如支架）释放的速率的膜。

公开(公告)号：US20080021008A1

公开(公告)日：2008-01-24

申请号：US11903011

申请日：2007-09-19

Applicant: Stephen Pacetti ,  Yiwen Tang

Inventor： Stephen Pacetti ,  Yiwen Tang

IPC: A61K31/33 ,  A61P43/00

CPC classification number: C08L71/02 ,  A61L31/10 ,  A61L31/16 ,  C08L33/08 ,  C08L33/10 ,  C08L75/04 ,  C09D133/08 ,  C09D133/10 ,  C09D133/12 ,  C08L2666/04 ,  C08L2666/22

Abstract: A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.

Abstract translation: 公开了一种用于可植入医疗装置的涂层及其制造方法。 涂层包括疏水性聚合物和聚合亲水性添加剂的混合物，其中疏水性聚合物和亲水性添加剂形成物理缠结或互穿系统。

公开(公告)号：US20070249801A1

公开(公告)日：2007-10-25

申请号：US11728209

申请日：2007-03-22

Applicant: Stephen Pacetti ,  Jessica DesNoyer

Inventor： Stephen Pacetti ,  Jessica DesNoyer

IPC: C08G69/44

CPC classification number: A61L31/10 ,  Y10T428/31725 ,  Y10T428/31768 ,  C08L77/12

Abstract: Coatings for an implantable medical devices such as stents and methods of fabricating thereof are disclosed. The coatings comprise a biologically absorbable poly(ester amide), which is a polymeric product of a reaction between a diol-diamine and a dicarboxylic acid.

Abstract translation: 公开了用于诸如支架的可植入医疗装置的涂层及其制造方法。 涂层包含生物可吸收的聚（酯酰胺），其是二醇 - 二胺和二羧酸之间的反应的聚合产物。

公开(公告)号：US20070196428A1

公开(公告)日：2007-08-23

申请号：US11356696

申请日：2006-02-17

Applicant: Thierry Glauser ,  Stephen Pacetti ,  Paul Consigny

Inventor： Thierry Glauser ,  Stephen Pacetti ,  Paul Consigny

IPC: A61K31/555 ,  A61F2/02

CPC classification number: A61K33/00 ,  A61K45/06 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/606

Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide attached to the medical device and methods of treating a vascular condition using the devices are provided.

Abstract translation: 提供了具有能够催化附着于医疗装置的一氧化氮的产生的催化剂的医疗装置和使用该装置治疗血管状态的方法。

公开(公告)号：US20070185564A1

公开(公告)日：2007-08-09

申请号：US11736979

申请日：2007-04-18

Applicant: Stephen Pacetti ,  Pamela Kramer

Inventor： Stephen Pacetti ,  Pamela Kramer

IPC: A61F2/06

CPC classification number: A61L31/18 ,  A61F2/91 ,  A61F2/92 ,  A61L31/022

Abstract: The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.

Abstract translation: 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。

公开(公告)号：US20070160642A1

公开(公告)日：2007-07-12

申请号：US11332683

申请日：2006-01-12

Applicant: Stephen Pacetti

Inventor： Stephen Pacetti

IPC: A61K31/513 ,  A61K31/445 ,  A61K31/421 ,  A61K31/4015 ,  A61F2/02

CPC classification number: A61K31/513 ,  A61K31/4015 ,  A61K31/421 ,  A61K31/445 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/61 ,  A61L2420/08 ,  C08L77/12 ,  C08L33/08

Abstract: This invention relates to implantable medical devices having a coating comprising small molecule superoxide dismutase mimics bonded to biocompatible durable polymers and to uses thereof in the treatment or prevention of vascular diseases.

Abstract translation: 本发明涉及具有包含结合生物相容耐久性聚合物的小分子超氧化物歧化酶模拟物的涂层及其用于治疗或预防血管疾病的可植入医疗装置。

公开(公告)号：US20060271170A1

公开(公告)日：2006-11-30

申请号：US11141834

申请日：2005-05-31

Applicant: David Gale ,  Klaus Kleine ,  Anthony Abbate ,  Svava Atladottir ,  Stephen Pacetti

Inventor： David Gale ,  Klaus Kleine ,  Anthony Abbate ,  Svava Atladottir ,  Stephen Pacetti

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0029

Abstract: A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.

Abstract translation: 公开了一种用于在高应变区域中用柔性部分处理身体管腔的支架。 柔性部分可以选择性地定位成在使用过程中受到施加的应力时，在高应变区域中减小应变量，以抑制或防止高应变区域中的断裂。

公开(公告)号：US20060216326A1

公开(公告)日：2006-09-28

申请号：US11089774

申请日：2005-03-24

Applicant: Stephen Pacetti

Inventor： Stephen Pacetti

IPC: A61F2/06

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/50 ,  A61L31/14 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/416 ,  A61L2300/606 ,  C08L33/14

Abstract: Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了由包含具有非结垢的丙烯酸酯或甲基丙烯酸酯聚合物的聚合物的材料形成或涂覆的可植入装置。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US20060147412A1

公开(公告)日：2006-07-06

申请号：US11027955

申请日：2004-12-30

Applicant: Syed Hossainy ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Stephen Pacetti

IPC: C08L89/00 ,  A61K31/765 ,  A61K31/785

CPC classification number: C08G63/912 ,  C08B37/0072 ,  C08B37/0075 ,  C08G63/06 ,  C08G63/664 ,  C08L1/08 ,  C08L1/286 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L25/18 ,  C08L33/26 ,  C08L39/06 ,  C08L67/04 ,  C08L71/02 ,  C08L77/12 ,  C09D101/286 ,  C09D105/02 ,  C09D105/08 ,  C09D105/10 ,  C09D167/04 ,  C08L2666/04 ,  C08L2666/26 ,  C08L2666/20 ,  C08L2666/06 ,  C08L2666/22

Abstract: Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).

Abstract translation: 公开了含有聚（羟基链烷酸酯）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有聚（羟基链烷酸酯）。

公开(公告)号：US20060136048A1

公开(公告)日：2006-06-22

申请号：US11015313

申请日：2004-12-16

Applicant: Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

Inventor： Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

IPC: A61F2/82

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.