公开(公告)号：US20240117363A1

公开(公告)日：2024-04-11

申请号：US18228251

申请日：2023-07-31

Applicant: The Scripps Research Institute

Inventor： Floyd E. ROMESBERG ,  Brian LAMB ,  Yorke ZHANG

IPC: C12N15/63 ,  C12N5/10 ,  C12N9/22 ,  C12N15/11 ,  C12N15/70

CPC classification number: C12N15/63 ,  C12N5/10 ,  C12N9/22 ,  C12N15/11 ,  C12N15/70 ,  C12N2310/20 ,  C12N2310/3519

Abstract: Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide.

公开(公告)号：US20240109956A1

公开(公告)日：2024-04-04

申请号：US18470044

申请日：2023-09-19

Applicant: International AIDS Vaccine Initiative ,  The Scripps Research Institute ,  The Texas A&M University System

Inventor： Devin SOK ,  Dennis R. BURTON ,  Vaughn V. SMIDER ,  Ian WILSON ,  Michael CRISCITIELLO ,  Waithaka MWANGI

IPC: C07K16/10 ,  C07K14/16

CPC classification number: C07K16/1063 ,  C07K14/162 ,  A61K38/00

Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab′)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

公开(公告)号：US11945806B2

公开(公告)日：2024-04-02

申请号：US17593812

申请日：2020-03-29

Applicant: The Scripps Research Institute

Inventor： Jeffery W. Kelly ,  Gareth John Morgan ,  Nicholas Lok Yan ,  Hank Michael James Petrassi

IPC: C07D471/10 ,  C07C255/30 ,  C07C311/39 ,  C07C317/24 ,  C07D207/06 ,  C07D207/48 ,  C07D215/227 ,  C07D233/72 ,  C07D235/02 ,  C07D239/47 ,  C07D311/18 ,  C07D319/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D487/10

CPC classification number: C07D405/12 ,  C07C255/30 ,  C07C311/39 ,  C07C317/24 ,  C07D207/06 ,  C07D207/48 ,  C07D215/227 ,  C07D233/72 ,  C07D235/02 ,  C07D239/47 ,  C07D311/18 ,  C07D319/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/12 ,  C07D471/10 ,  C07D487/10

Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

公开(公告)号：US20240083954A1

公开(公告)日：2024-03-14

申请号：US18449739

申请日：2023-08-15

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Leopold Kong ,  Ian A. Wilson ,  Natalia de Val ,  Andrew B. Ward ,  Dennis Burton ,  Linling He ,  Jiang Zhu

IPC: C07K14/16 ,  A61K39/21 ,  A61K47/69 ,  C07K14/005

CPC classification number: C07K14/162 ,  A61K39/21 ,  A61K47/6929 ,  C07K14/005 ,  A61K39/12 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

公开(公告)号：US20230390318A1

公开(公告)日：2023-12-07

申请号：US18233959

申请日：2023-08-15

Applicant: The Scripps Research Institute

Inventor： Arnab K. Chatterjee ,  Anil K. Gupta ,  Anders M. Eliasen ,  Sean B. Joseph

IPC: A61K31/7076 ,  A61P31/20 ,  A61P31/18 ,  A61K9/00 ,  A61K47/26 ,  A61K47/38 ,  A61K9/10 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/675 ,  C07H19/16

CPC classification number: A61K31/7076 ,  A61P31/20 ,  A61P31/18 ,  A61K9/0019 ,  A61K47/26 ,  A61K47/38 ,  A61K9/10 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/675 ,  C07H19/16

Abstract: Diesters of 4′-ethynyl-2-fluoro-2′-deoxyadenosine and aqueous parenteral suspensions thereof provide extended in vivo viral suppression of human immunodeficiency virus (HIV).

公开(公告)号：US11834689B2

公开(公告)日：2023-12-05

申请号：US17196151

申请日：2021-03-09

Applicant: SYNTHORX, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Jerod Ptacin ,  Carolina Caffaro ,  Hans Aerni ,  Yorke Zhang ,  Emil C. Fischer ,  Aaron W. Feldman ,  Vivian T. Dien ,  Floyd E. Romesberg

IPC: C12N9/00 ,  C12P21/02 ,  C12N15/113 ,  C12N15/90

CPC classification number: C12N9/93 ,  C12N15/113 ,  C12N15/90 ,  C12P21/02 ,  C12Y601/01026

Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

公开(公告)号：US20230357253A1

公开(公告)日：2023-11-09

申请号：US18043649

申请日：2021-09-02

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Hank Michael James Petrassi ,  Luke L. Lairson ,  Emily Chin ,  Peter G. Schultz ,  Chenguang Yu ,  Baiyuan Yang ,  Virginia Grant ,  Yongkai Li ,  Alexander Pacheco ,  Alan Chu ,  Kristen Johnson ,  Arnab K. Chatterjee

IPC: C07D487/04 ,  C07D519/00 ,  C07D403/14 ,  C07D413/14 ,  C07F9/6558 ,  C07D409/14 ,  C07D405/14 ,  C07D401/14 ,  C07D237/24 ,  A61K45/06

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07D403/14 ,  C07D413/14 ,  C07F9/65583 ,  C07D409/14 ,  C07D405/14 ,  C07D401/14 ,  C07D237/24 ,  A61K45/06

Abstract: Disclosed herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and their pharmaceutical compositions: The compounds are useful as agonists of Stimulator of Interferon Genes (STING), such as in a method of treating a tumor.

公开(公告)号：US11802159B2

公开(公告)日：2023-10-31

申请号：US17037203

申请日：2020-09-29

Applicant: The Trustees of the University of Pennsylvania ,  The Scripps Research Institute

Inventor： Donald L. Siegel ,  Vijay Bhoj ,  Christoph Rader ,  Rebecca Goydel

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K35/17 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the glycosyl-phosphatidylinositol (GPI)-linked GDNF family protein α-receptor 4 (GFRα4).

公开(公告)号：US20230312499A1

公开(公告)日：2023-10-05

申请号：US18053582

申请日：2022-11-08

Applicant: H. Lundbeck A/S ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Micah J. NIPHAKIS ,  Jae Won CHANG ,  Kenneth M. LUM ,  Benjamin F. CRAVATT

IPC: C07D295/205 ,  C07C271/12 ,  C07D317/46 ,  C07D317/58 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D471/04 ,  C07D471/10 ,  C07D261/08 ,  C07D487/04 ,  C07D263/32 ,  C07D205/04 ,  C07D491/107 ,  C07D207/14 ,  C07D271/06 ,  C07D307/79 ,  C07D405/14 ,  C07D215/42 ,  C07D213/40 ,  A61P25/22 ,  C07D295/26 ,  C07D213/55 ,  C07D401/04 ,  C07D407/06 ,  C07D413/06 ,  C07C271/10 ,  C07D207/09 ,  C07D213/38 ,  C07D215/46 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

CPC classification number: C07D295/205 ,  C07C271/12 ,  C07D317/46 ,  C07D317/58 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D471/04 ,  C07D471/10 ,  C07D261/08 ,  C07D487/04 ,  C07D263/32 ,  C07D205/04 ,  C07D491/107 ,  C07D207/14 ,  C07D271/06 ,  C07D307/79 ,  C07D405/14 ,  C07D215/42 ,  C07D213/40 ,  A61P25/22 ,  C07D295/26 ,  C07D213/55 ,  C07D401/04 ,  C07D407/06 ,  C07D413/06 ,  C07C271/10 ,  C07D207/09 ,  C07D213/38 ,  C07D215/46 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.

公开(公告)号：US20230303667A1

公开(公告)日：2023-09-28

申请号：US18332291

申请日：2023-06-09

Applicant: Emory University ,  The Scripps Research Institute

Inventor： Rafi Ahmed ,  Carl Davis ,  Erica Ollmann Saphire

IPC: C07K16/10 ,  A61P31/14 ,  C12Q1/70

CPC classification number: C07K16/10 ,  A61P31/14 ,  C12Q1/701 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/524 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

Abstract: This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or preventing an Ebola viral infection. In certain embodiments, the antibodies and antigen binding fragments are also contemplated for diagnostic methods and compositions related thereto.