公开(公告)号：US20190257289A1

公开(公告)日：2019-08-22

申请号：US16315313

申请日：2017-07-06

Applicant: Universität Stuttgart

Inventor： David SCHLIPF ,  Holger FÜRST ,  Florian HAIZMANN ,  Steffen RAACH

IPC: F03D7/04

Abstract: Summarizing, the present invention relates to a control system for a wind turbine including—a feed forward controller having a rotor effective wind speed of the wind turbine as an input parameter and having a plurality of output parameters—a feedback controller wherein an input parameter is based on a rotor speed or a generator speed of the wind turbine and having at least one output parameter and wherein o one output parameter of the feed forward controller is provided to the feedback controller as an input parameter and o another output parameter of the feed forward controller is used as a feed-forward control parameter for controlling the wind turbine and o one output parameter of the feedback controller is used as a feed-back control parameter for controlling the wind turbine, as well as a wind turbine and a control method.

公开(公告)号：US20190194350A1

公开(公告)日：2019-06-27

申请号：US16326864

申请日：2017-09-15

Applicant: UNIVERSITÄT STUTTGART

Inventor： Roland KONTERMANN ,  Lisa SCHMITT ,  Meiko HUTT ,  Oliver SEIFERT ,  Monilola OLAYIOYE ,  Michael HUST ,  Stefan DÜBEL ,  Jonas ZANTOW

IPC: C07K16/32 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/32 ,  A61K39/39558 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

Abstract: The present invention provides an antigen-binding protein that specifically binds to a conformational epitope formed by domain III & IV of human epidermal growth factor receptor 3 (HER3) and antigen-binding proteins which compete therewith for binding, as well as fusion protein or conjugate comprising these. The present invention also provides nucleic acid molecule comprising a sequence encoding said antigen binding proteins, vectors comprising the nucleic acid, and cells and pharmaceuticals comprising the antigen binding protein, the fusion protein, the nucleic acid, or the vector. The present invention also provides the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical for use as a medicament. The present invention further provides a method of inhibiting tumor growth or treating cancer, comprising administering a therapeutically effective amount of the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical.

公开(公告)号：US20190144555A1

公开(公告)日：2019-05-16

申请号：US16091456

申请日：2017-04-04

Applicant: UNIVERSITÄT STUTTGART ,  BALIOPHARM AG

Inventor： Roland KONTERMANN ,  Klaus PFIZENMAIER ,  Fabian RICHTER ,  Kirstin ZETTLITZ ,  Peter SCHEURICH ,  Andreas HERRMANN

IPC: C07K16/28 ,  A61P37/06

CPC classification number: C07K16/2878 ,  A61P37/06 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides for an inhibitor of the huTNFRI receptor which is a human or humanized antibody construct that monovalently recognizes huTNFRI through an antigen-binding moiety, which is characterized by specific CDR sequences, a pharmaceutical preparation thereof, method of producing the inhibitor and the medical use of the inhibitor.

公开(公告)号：US10072036B2

公开(公告)日：2018-09-11

申请号：US15306521

申请日：2015-04-24

Applicant: UNIVERSITÄT STUTTGART

Inventor： Michael R. Buchmeiser ,  Suman Sen ,  Roman Schowner

IPC: C07F11/00 ,  C07C6/04 ,  C08G61/08 ,  C08G61/12 ,  C07C319/20 ,  C07C253/30 ,  C07C67/333 ,  B01J31/18 ,  B01J31/22

CPC classification number: C07F11/00 ,  B01J31/1805 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07C6/04 ,  C07C67/333 ,  C07C253/30 ,  C07C319/20 ,  C07C2531/22 ,  C07C2601/10 ,  C07C2601/16 ,  C08G61/08 ,  C08G61/12 ,  C08G2261/418 ,  C08G2261/419 ,  C07C13/20 ,  C07C11/02 ,  C07C255/46 ,  C07C321/28 ,  C07C69/74

Abstract: The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2 R2′, NR2, PR2, 0 or S, A3 stands for N or P, and C stands for a carbene carbon atom, ring B is an unsubstituted or a mono or poly-substituted 5 to 7-membered ring, substituents R2 and R2′ stand, inter alia, for a linear or branched C1-Cw-alkyl group and, if N and N each stand for NR2 or PR2, are the same or different, M in formulas I, II, III or IV stands for Cr, Mo or W, X 1 or X2 in formulas I to IV are the same or different and represent, inter alia, C1-C1s carboxylates and C1-C1s-alkoxides, Y is inter alia oxygen or sulphur, Z is inter alia a linear or branched C1-Cw-alkylenoxy group, and R 1 and R1′ in formulas I to IV are, inter alia, an aliphatic or aromatic group. These compounds are particularly suitable for use as catalysts for olefin metathesis reactions and have the advantage, compared to known Schrock carbene complexes, of displaying clearly increased tolerance to functional groups such as, in particular, aldehydes, secondary amines, nitriles, carboxylic acids and alcohols.

公开(公告)号：US20180202872A1

公开(公告)日：2018-07-19

申请号：US15572360

申请日：2016-05-20

Applicant: Universität Stuttgart

Inventor： Wolfgang Osten ,  Giancarlo Pedrini ,  Rainer Gadow ,  Klaus Körner

IPC: G01L1/06 ,  G01B11/16 ,  G01B11/24 ,  B05D1/00 ,  B05C11/00

CPC classification number: G01L1/06 ,  B05C11/00 ,  B05D1/00 ,  G01B11/16 ,  G01B11/24 ,  G01L5/0047

Abstract: The present invention relates to a method and an apparatus for establishing residual stresses in objects, in particular in coated objects, and to a method and an apparatus for coating objects. The method comprises: impinging a surface (8) of the object (5) with laser light and generating a hole or a pattern of holes and/or locally heated points in the object (5); establishing the surface deformations by an optical deforming measuring method after the object (5) is impinged by laser light; establishing the residual stresses present in the object (5) from the measured surface deformations, wherein the generation of the hole pattern is carried out by an optical scanning apparatus which comprises an optical deflection and/or modulation arrangement for controllable deflection and/or modulation of the laser light, and/or a focusing arrangement for controllable focusing of the laser light.

公开(公告)号：US20170096656A1

公开(公告)日：2017-04-06

申请号：US15110132

申请日：2015-01-12

Applicant: MATIS OHF. ,  RIJKSUNIVERSITEIT GRONINGEN ,  UNIVERSITÄT STUTTGART

Inventor： Gudmundur Oli Hreggvidsson ,  Jon Oskar Jonsson Wheat ,  Bryndis Bjornsdottir ,  Olafur Hedinn Fridjonsson ,  Josef Altenbuchner ,  Hildegard Watzlawick ,  Justyna M. Dobruchowska ,  Johannis P. Kamerling

IPC: C12N9/88 ,  C12P19/02

CPC classification number: C12N9/88 ,  C12P19/02

Abstract: The present invention relates to the identification, production and use of thermostable alginate lyase enzymes that can be used to partially degrade alginate to yield oligosaccharides or to give complete degradation of alginate to yield (unsaturated) mono-uronates.

公开(公告)号：US20160371863A1

公开(公告)日：2016-12-22

申请号：US15183189

申请日：2016-06-15

Applicant: Universität Stuttgart

Inventor： Sven Simon ,  Steffen Kieß ,  Jürgen Hillebrand ,  Jajnabalkya Guhathakurta

IPC: G06T11/00 ,  G06T7/00

CPC classification number: G06T11/006 ,  G06T2211/424

Abstract: The present invention relates to a method and a computer program product for generating an artefact-reduced voxel data record of an object. The artefact-reduced voxel data record of the object is generated with the aid of a computed tomography scanner. In some aspects of the present disclosure, a first image data record and a second image data record is generated by acquiring computed tomography images of the object. In still other aspects of the present disclosure, the artefact-reduced voxel data record of the object is generated with the aid of an image data reconstruction algorithm.

Abstract translation: 本发明涉及一种用于生成物体的假象减少体素数据记录的方法和计算机程序产品。 借助于计算机断层扫描仪生成物体的人为减少体素数据记录。 在本公开的一些方面，通过获取对象的计算机断层摄影图像来生成第一图像数据记录和第二图像数据记录。 在本公开的另外的方面中，借助于图像数据重建算法生成对象的假象减少的体素数据记录。

公开(公告)号：US20160274308A1

公开(公告)日：2016-09-22

申请号：US15074668

申请日：2016-03-18

Applicant: Universität Stuttgart

Inventor： Harald GIESSEN ,  Stefan Kedenburg ,  Timo Gissibl ,  Andy Steinmann

IPC: G02B6/38 ,  G02B6/26

CPC classification number: G02B6/3802 ,  B33Y80/00 ,  G02B6/02385 ,  G02B6/255 ,  G02B6/262 ,  G02B2006/0325

Abstract: The present invention relates to a method for connecting a solid core optical fiber (2) with another optical fiber (20), wherein the solid core optical fiber (2) comprises a joining device (10), which is created on one axial end of the solid core optical fiber (2) using a 3D printer and wherein the other optical fiber (20) is incorporated in the joining device (10) via an axial end of the other optical fiber (20), which is thus connected with the solid core optical fiber (2). In addition, the invention relates to a solid core optical fiber (2) with a joining device (10) created by a 3D-printer, and the relevant use of a 3D printer.

Abstract translation: 本发明涉及一种将实芯光纤（2）与另一光纤（20）连接的方法，其中固体芯光纤（2）包括接合装置（10），其在 所述实芯光纤（2）使用3D打印机，并且其中所述另一光纤（20）经由所述另一光纤（20）的轴向端部并入所述接合装置（10）中，所述另一光纤（20）因此与所述固体 芯光纤（2）。 另外，本发明涉及具有由3D打印机创建的接合装置（10）的实芯光纤（2）以及3D打印机的相关使用。

公开(公告)号：US20160143539A1

公开(公告)日：2016-05-26

申请号：US14936048

申请日：2015-11-09

Applicant: Universität Stuttgart

Inventor： Klaus Koerner ,  Daniel Claus ,  Alois Herkommer ,  Wolfgang Osten

IPC: A61B5/00 ,  G01J3/42 ,  G01J3/02

CPC classification number: A61B5/0086 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/4836 ,  A61B5/6848 ,  A61B2562/0238 ,  A61N2005/0612 ,  G01J3/0202 ,  G01J3/0213 ,  G01J3/42 ,  G01N21/552 ,  G01N21/8507 ,  G01N2021/434

Abstract: Disclosed herein is a measuring probe, an apparatus, and a method for infrared spectroscopy. In some embodiments the measuring probe may have an elongated form with a first end for coupling and decoupling infrared light into and out of the measuring probe and a second end. In other embodiments, the measuring probe may comprise an attenuated total reflection (ATR) prism arranged at the second end of the measuring probe. The ATR prism may include at least a first surface having at least one measuring portion configured to be brought in optical contact with a measured object. The ATR prism may include at least a second surface having at least one reflective portion. In some embodiments, the ATR prism may include a cutting portion for cutting through the measured object.

Abstract translation: 本文公开了一种用于红外光谱的测量探针，装置和方法。 在一些实施例中，测量探针可以具有细长形式，其具有第一端，用于将红外光耦合和分离出测量探针和从测量探针和第二端分离。 在其他实施例中，测量探针可以包括布置在测量探针的第二端处的衰减全反射（ATR）棱镜。 ATR棱镜可以包括至少一个第一表面，该第一表面具有至少一个测量部分，该测量部分被配置为与测量对象进行光学接触。 ATR棱镜可以包括具有至少一个反射部分的至少第二表面。 在一些实施例中，ATR棱镜可以包括用于切割被测物体的切割部分。

公开(公告)号：US20150380891A1

公开(公告)日：2015-12-31

申请号：US14759728

申请日：2013-01-09

Applicant: UNIVERSITÄT STUTTGART

Inventor： Johannes FRÜCHTENICHT

IPC: H01S3/101 ,  G02F1/09 ,  G02F1/03 ,  H01S3/00

CPC classification number: H01S3/101 ,  B23K26/0604 ,  B23K26/0676 ,  G02B27/09 ,  G02B27/0977 ,  G02B27/144 ,  G02B27/48 ,  G02F1/0311 ,  G02F1/093 ,  H01S3/0064 ,  H01S3/0085 ,  H01S3/105 ,  H01S3/2325 ,  H01S3/235

Abstract: An optical rotating device for injecting a laser beam may include deflection devices between which the injected laser beam may rotate in the optical rotating device, and an extraction device that may extract the laser beam after carrying out a predetermined number of rotations in the rotating device. The deflection devices may be arranged such that the position of the laser beam during extraction is dependent on the number of rotations carried out in the optical rotating device.

Abstract translation: 用于注射激光束的光学旋转装置可以包括注入的激光束可以在旋转装置内旋转的偏转装置，以及在旋转装置中执行预定转数之后可以提取激光束的提取装置。 偏转装置可以被布置成使得在提取期间激光束的位置取决于在旋转装置中执行的转数。