公开(公告)号：US10231985B2

公开(公告)日：2019-03-19

申请号：US15028139

申请日：2014-10-08

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE POITIERS ,  UNIVERSITY OF EXETER

Inventor： Miroslava Spanova ,  Thierry Ferreira ,  Romain Clement ,  Shalinee Dhayal ,  Noël Morgan

IPC: A61K31/231 ,  A61K31/357 ,  A61K31/7032 ,  A61K31/661 ,  A61K31/232 ,  A61K31/7024 ,  A61K31/201 ,  A61K45/06 ,  A23L33/12 ,  A61K31/164

Abstract: The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.

公开(公告)号：US10146007B2

公开(公告)日：2018-12-04

申请号：US14760306

申请日：2014-01-23

Applicant: President and Fellows of Harvard College ,  University of Exeter

Inventor： Joanna Aizenberg ,  Mathias Kolle ,  Peter Vukusic ,  Robert D. Howe

IPC: G02B6/00 ,  G02B6/02 ,  G01L1/24 ,  G02B1/00 ,  G02B6/028 ,  G02B6/036

Abstract: The rolled photonic fibers presents two codependent, technologically exploitable features for light and color manipulation: regularity on the nanoscale that is superposed with microscale cylindrical symmetry, resulting in wavelength selective scattering of light in a wide range of directions. The bio-inspired photonic fibers combine the spectral filtering capabilities and color brilliance of a planar Bragg stack compounded with a large angular scattering range introduced by the microscale curvature, which also decreases the strong directional chromaticity variation usually associated with flat multilayer reflectors. Transparent and elastic synthetic materials equip the multilayer interference fibers with high reflectance that is dynamically tuned by longitudinal mechanical strain. A two-fold elongation of the elastic fibers results in a shift of reflection peak center wavelength of over 200 nm.

公开(公告)号：US20180317793A1

公开(公告)日：2018-11-08

申请号：US15773735

申请日：2016-11-03

Applicant: University of Exeter

Inventor： John TERRY ,  Harry GREEN

IPC: A61B5/0468 ,  A61B5/046 ,  A61B5/0402 ,  G16H50/50

CPC classification number: A61B5/0468 ,  A61B5/04028 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/6852 ,  A61B5/6856 ,  A61B5/7282 ,  A61B18/1492 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2505/05 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: A system adapted to detect one or more conduction gaps in a pulmonary vein of a patient, the system including a device configured to receive or obtain a plurality of pulmonary vein recordings in respect of said patient, each pulmonary vein recording being representative of electrical signals detected or predicted at respective electrodes or between respective pairs of electrodes located or simulated within said pulmonary vein, a device configured to determine a respective activation time for each of said plurality of pulmonary vein recordings and generating curve data representative of said activation times, and a device configured to determine the presence of one or more conduction gaps by identifying one or more respective earliest activation times.

公开(公告)号：US10053772B2

公开(公告)日：2018-08-21

申请号：US15026437

申请日：2014-09-26

Applicant: University of Exeter

Inventor： Saverio Russo ,  Monica Craciun ,  Thomas Hardisty Bointon

IPC: C23C16/26 ,  C01B32/194 ,  C01B32/188 ,  C01B32/186 ,  H01B1/04 ,  B82Y40/00

CPC classification number: C23C16/26 ,  B82Y40/00 ,  C01B32/186 ,  C01B32/188 ,  C01B32/194 ,  H01B1/04

Abstract: Methods of producing a uniformly or substantially uniformly doped relatively large area multi-layered graphene element are described comprising the steps of placing the graphene element and a dopant under low pressure conditions, and holding the graphene element and dopant at an elevated temperature for a period of time while under the low pressure conditions. In one arrangement, openings are formed in a multi-layered graphene element of relatively large area prior to doping. In another arrangement, a relatively large area multi-layered graphene element formed by an epitaxial growth technique is used. The invention also relates to an element produced using the aforementioned techniques.

公开(公告)号：US09919049B2

公开(公告)日：2018-03-20

申请号：US15315699

申请日：2015-06-02

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott Wood ,  Paul Graham Winyard ,  Daniel Colin Jeremy Ferguson ,  Matthew Whiteman ,  Alison Curnow ,  Alexis Perry

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

公开(公告)号：US09720151B1

公开(公告)日：2017-08-01

申请号：US14048665

申请日：2013-10-08

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  University of Exeter

Inventor： Ganapathi Subramanian Subramania ,  Igal Brener ,  Stavroula Foteinopoulou

IPC: G02B5/20 ,  G02B5/00 ,  G02B6/10 ,  G02B1/00

CPC classification number: G02B5/208 ,  G02B1/002 ,  G02B5/008 ,  G02B6/107 ,  G02F2202/30

Abstract: A structure for broadband light funneling comprises a two-dimensional periodic array of connected ultrasubwavelength apertures, each aperture comprising a large sub-aperture that aids in the coupling of the incoming incident light and a small sub-aperture that funnels a significant fraction of the incident light power. The structure possesses all the capabilities of prior extraordinary optical transmission platforms, yet operates nonresonantly on a distinctly different mechanism. The structure demonstrates efficient ultrabroadband funneling of optical power confined in an area as small as ˜(λ/500)2, where optical fields are enhanced, thus exhibiting functional possibilities beyond resonant platforms.

公开(公告)号：US20170202966A1

公开(公告)日：2017-07-20

申请号：US15315699

申请日：2015-06-02

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott WOOD ,  Paul Graham WINYARD ,  Daniel Colin Jeremy FERGUSON ,  Matthew WHITEMAN ,  Alison CURNOW ,  Alexis PERRY

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy

公开(公告)号：US20140311244A1

公开(公告)日：2014-10-23

申请号：US14319342

申请日：2014-06-30

Applicant: UNIVERSITY OF EXETER

Inventor： Peter Robert Armitage

IPC: G01N29/04

CPC classification number: G01N29/04 ,  G01N29/043 ,  G01N29/12 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4445 ,  G01N2291/014 ,  G01N2291/106 ,  G01N2291/2694

Abstract: Device and method for detecting a defect in a workpiece with a broadband transducer (10), a driving circuit connected to the transducer to operate the transducer in a actuator mode, a signal output circuit connectable to operate in a sensor mode, a control for selectively connecting the transducer to the driving circuit or signal output circuit wherein the driving circuit includes at least a pair of oscillators for generating signals of at least frequencies F1 and F2 and a summer for summing the signals to provide a driving circuit for the transducer.

Abstract translation: 用于使用宽带传感器（10）检测工件中的缺陷的装置和方法，连接到换能器以在致动器模式下操作换能器的驱动电路，可连接以传感器模式操作的信号输出电路，用于选择性地 将所述换能器连接到所述驱动电路或信号输出电路，其中所述驱动电路至少包括一对用于产生至少频率F1和F2的信号的振荡器，以及用于对所述信号求和以提供所述换能器的驱动电路的加法器。

公开(公告)号：US20240288042A1

公开(公告)日：2024-08-29

申请号：US18573768

申请日：2022-06-29

Applicant: UNIVERSITY OF EXETER

Inventor： Luke SAVAGE ,  Zoltan GOMBOS

IPC: F16D65/092 ,  F16D69/02 ,  F16D69/04

CPC classification number: F16D65/092 ,  F16D69/026 ,  F16D69/0408 ,  F16D2200/0086 ,  F16D2200/0091

Abstract: A brake pad unit for a disc brake assembly. The brake pad unit comprises a backing plate and a friction pad. The backing plate comprises a first side and a second side having a length L, a width W, and an edge wall which defines a thickness T of the backing plate. The first side defines an engagement surface for engaging with the disc brake assembly. The second side defines a friction material mounting surface. The backing plate is formed from a composite material comprising reinforcement fibres, wherein the composite material extends throughout of the backing plate. The backing plate comprises a layer of reinforcement fibres which are provided as continuous fibres which extend from a first point on the edge wall to a second point on the edge wall. The friction pad comprises a friction material provided on the friction material mounting surface of the backing plate.

公开(公告)号：US20240079973A1

公开(公告)日：2024-03-07

申请号：US18262446

申请日：2022-02-11

Applicant: UNIVERSITY OF EXETER

Inventor： Zheng Jun CHEW ,  Yang KUANG ,  Tingwen RUAN ,  Meiling ZHU

IPC: H02N2/18

CPC classification number: H02N2/186 ,  H02N2/181

Abstract: An energy harvesting device is described comprising a piezoelectric material element (22), a proof mass (18) moveable relative to the piezoelectric material element (22) and coupled to the piezoelectric material element (22) by a coupling arrangement such that movement of the proof mass (18) causes compression of the piezoelectric material element (22), wherein the proof mass (18) defines a cavity (20), the piezoelectric material element (22) being located, at least in part, within the cavity (20). A power management circuit (50) suitable for use therewith is also described, the circuit (50) comprising a configurable voltage amplification and rectification circuit and a mode control circuit operable to configure the configurable circuit to operate in a voltage amplification mode or in a rectification mode, the mode control circuit selecting the operating mode depending upon the input or output of the configurable circuit.