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214 条记录 (耗时 0.088 秒)

    Diagnostic testing process and apparatus
    13.
    发明申请
    Diagnostic testing process and apparatus 审中-公开
    诊断测试过程和设备

    公开(公告)号：US20070190667A1

    公开(公告)日：2007-08-16

    申请号：US11787523

    申请日：2007-04-17

    申请人： Robert Cole ,  Andrew Sloane ,  William Hunter

    发明人： Robert Cole ,  Andrew Sloane ,  William Hunter

    IPC分类号： G01N33/543

    CPC分类号： B01L3/5023 ,  B01L2200/0642 ,  B01L2300/0825 ,  B01L2300/16 ,  B01L2400/0406 ,  B01L2400/0633 ,  G01N33/54306 ,  G01N33/54366 ,  Y02A50/58 ,  Y10S435/81 ,  Y10S435/973 ,  Y10S436/81

    摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.

    摘要翻译： 公开了一种用于流过测定过程的方法和装置。 该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为与胶体金或荧光标签结合的抗体） 已知结合特定蛋白质的蛋白质可以结合在一起所需的时间段。 该预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。 提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。 公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。 在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。 在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

    Medical implants and anti-scarring agents
    14.
    发明申请
    Medical implants and anti-scarring agents 审中-公开
    医疗植入物和抗瘢痕形成剂

    公开(公告)号：US20060147492A1

    公开(公告)日：2006-07-06

    申请号：US11343809

    申请日：2006-01-31

    申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins

    发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins

    IPC分类号： A61F2/00 ,  A61K31/47

    CPC分类号： A61L31/16 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/1219 ,  A61F2250/0067 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/432 ,  A61N1/05

    摘要： Implants are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal. The agent may be any suitable anti-scarring agent, e.g., a cell cycle inhibitor, and may be used in conjunction with a second pharmaceutical agent, e.g., an antibiotic. Suitable implants include intravascular implants, a vascular graft or wrap implant, an implant for hemodialysis access, an implant that provides an anastomotic connection, ventricular assist implant, a prosthetic heart valve implant, an inferior vena cava filter implant, a peritoneal dialysis catheter implant, a central nervous system shunt, an intraocular lens, an implant for glaucoma drainage, a penile implant, an endotracheal tube, a tracheostomy tube, a gastrointestinal device, and a spinal implant.

    摘要翻译： 植入物与抗瘢痕形成剂组合使用以抑制当植入物置于动物体内时可能发生的瘢痕形成。 该试剂可以是任何合适的抗瘢痕形成剂，例如细胞周期抑制剂，并且可以与第二药剂如抗生素联合使用。 合适的植入物包括血管内植入物，血管移植物或包裹植入物，用于血液透析通路的植入物，提供吻合连接的植入物，心室辅助植入物，假体心脏瓣膜植入物，下腔静脉滤器植入物，腹膜透析导管植入物， 中枢神经系统分流器，眼内透镜，用于青光眼引流的植入物，阴茎植入物，气管内导管，气管造口管，胃肠装置和脊柱植入物。

    Squeeze station for automated molding machine
    16.
    发明申请
    Squeeze station for automated molding machine 有权

    公开(公告)号：US20060118267A1

    公开(公告)日：2006-06-08

    申请号：US11005642

    申请日：2004-12-06

    申请人： William Hunter

    发明人： William Hunter

    IPC分类号： B22C9/00 ,  B22C15/02

    CPC分类号： B22C15/02

    摘要： An automated matchplate molding machine includes a cope flask, a pattern plate and a drag flask for creating formed sand molds. A lock is provided to lock the drag flask to the platen table of the molding machine during desired stages of an individual sand molding sequence. The lock between the drag flask and the platen table may include actuated pins which engage corresponding detent structures such as tapered holes integral with the drag flask and prevent lateral migration of the drag flask relative to the platen table. Additionally, cope flask actuators are provided which vertically support and are operable to raise the cope flask relative to the squeeze head to facilitate release the cope mold from the cope flask.