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公开(公告)号：US11613554B2
公开(公告)日：2023-03-28
申请号：US16382692
申请日：2019-04-12
Inventor： Michael Anthony Schmidt , Bin Zheng , Kyle Knouse , Justine deGruyter , Martin D. Eastgate , Phil Baran , William R. Ewing , Richard E. Olson , Ivar M. McDonald
IPC: C07H21/00
Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
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公开(公告)号：US11479581B2
公开(公告)日：2022-10-25
申请号：US16618847
申请日：2018-06-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gardner S. Creech , Mahboubeh Kheirabadi , Martin D. Eastgate , David S. Nirschl , Percy H. Carter
IPC: C07K1/04 , C07K1/113 , C07K7/64 , C07C309/75 , C07C309/77 , C07D225/08 , C07K1/107 , C07K17/08
Abstract: The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving the capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.
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公开(公告)号：US20160130260A1
公开(公告)日：2016-05-12
申请号：US14896995
申请日：2014-06-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Tamas Benkovics , Martin D. Eastgate
IPC: C07D407/04
CPC classification number: C07D407/04 , C07C315/04 , C07C319/14 , C07C319/20 , C07C317/18 , C07C323/65
Abstract: Tert-butyl sulphoxide method for producing festinavir is set forth.
Abstract translation: 阐述了用于制备节食者的叔丁基亚砜方法。
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14.发明申请Pyrazolopyrimidine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication 有权吡唑并嘧啶大环化合物作为人类免疫缺陷病毒复制的抑制剂公开(公告)号：US20150232481A1
公开(公告)日：2015-08-20
申请号：US14619728
申请日：2015-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： B. Narasimhulu Naidu , Michael A. Walker , Margaret E. Sorenson , Manoj Patel , Zhizhen Barbara Zheng , John F. Kadow , Bin Zheng , Martin D. Eastgate , Ke Chen , Francisco Gonzalez-Bobes
IPC: C07D498/22
CPC classification number: C07D498/22 , C07D211/48
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US20150038716A1
公开(公告)日：2015-02-05
申请号：US14516641
申请日：2014-10-17
Applicant: Bristol-Myers Squibb Company
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07D405/04 , C07D207/333
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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Patent Agency Ranking
公开(公告)号：US10106560B2
公开(公告)日：2018-10-23
申请号：US15623570
申请日：2017-06-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Adrian Ortiz , Carlos A. Guerrero , Bin Zheng , Jason J. Zhu , Michael Anthony Schmidt , Michael R. Luzung , Martin D. Eastgate
IPC: C07D417/12 , C07F7/18 , C07D211/28 , C07F7/08
Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
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17.发明授权Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权制备HIV附着抑制剂哌嗪前药化合物的方法公开(公告)号：US09394322B2
公开(公告)日：2016-07-19
申请号：US14516661
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D405/06 , C07F9/09 , C07F9/6561 , C07D471/04 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
Abstract translation: 使用原料制备化合物的方法
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18.发明授权Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication 有权吡唑并嘧啶大环化合物作为人类免疫缺陷病毒复制的抑制剂公开(公告)号：US09273067B2
公开(公告)日：2016-03-01
申请号：US14619728
申请日：2015-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： B. Narasimhulu Naidu , Michael A. Walker , Margaret E. Sorenson , Manoj Patel , Zhizhen Barbara Zheng , John F. Kadow , Bin Zheng , Martin D. Eastgate , Ke Chen , Francisco Gonzalez-Bobes
IPC: C07D498/22 , C07D211/48
CPC classification number: C07D498/22 , C07D211/48
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US09249168B2
公开(公告)日：2016-02-02
申请号：US14516669
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07F9/09 , C07F9/6561 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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20.发明授权Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权制备HIV附着抑制剂哌嗪前药化合物的方法公开(公告)号：US09243010B2
公开(公告)日：2016-01-26
申请号：US14516641
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07F9/09 , C07F9/6561 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A process for the preparation of the compound of Formula I is set forth utilizing the starting compound 1 and the acid chloride compound
Abstract translation: 使用起始化合物1和酰氯化合物来阐述制备式I化合物的方法
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