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11.发明申请公开(公告)号：US20160158748A1
公开(公告)日：2016-06-09
申请号：US14960010
申请日：2015-12-04
Inventor： Ming-Chiang Wu , Jodi Tsu-An Loo , Shao Ning Pei , Gaetan L. Mathieu , Jian Gong , Randall D. Lowe, JR. , Justin K. Valley
IPC: B01L3/00 , G01N27/447
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502715 , B01L3/502792 , B01L2200/06 , B01L2300/0654 , B01L2300/0816 , B01L2300/0858 , B01L2300/0877 , B01L2300/12 , B01L2300/165 , B01L2400/0427 , G01N27/44704 , G01N27/44743 , G01N27/44791
Abstract: Single-sided optoelectrowetting (SSOEW)-configured substrates are provided, as well as microfluidic devices that include such substrates. The substrates can include a planar electrode, a photoconductive (or photosensitive) layer, a dielectric layer (single-layer or composite), a mesh electrode, and a hydrophobic coating. Fluid droplets can be moved across the hydrophobic coating of such substrates in a light-actuated manner, upon the application of a suitable AC voltage potential across the substrate and the focusing of light into the photoconductive layer of the substrate in a location proximal to the droplets. Walls can be disposed upon the substrates to form the microfluidic devices. Together the walls and substrate can form a microfluidic circuit, through which droplets can be moved.
Abstract translation: 提供了单面光电注入（SSOEW）配置的基板，以及包括这种基板的微流体装置。 基板可以包括平面电极，光导（或感光）层，电介质层（单层或复合），网状电极和疏水涂层。 当在基板上施加合适的AC电压电位并且将光聚焦到基板的光电导层中时，流体液滴可以以光致致动的方式移动穿过这种基板的疏水涂层 。 壁可以设置在基底上以形成微流体装置。 壁和基底可以一起形成微流体电路，通过该微流体电路可以移动液滴。
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12.发明授权公开(公告)号：US11964275B2
公开(公告)日：2024-04-23
申请号：US17005116
申请日：2020-08-27
Applicant: Berkeley Lights, Inc.
Inventor： Randall D. Lowe, Jr. , Shao Ning Pei , Jian Gong , Alexander J. Mastroianni , Jason M. McEwen , Justin K. Valley
CPC classification number: B01L3/50273 , C12M23/16 , C12M29/10 , B01L2200/0647 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2400/0427
Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species. Also provided are microfluidic devices having an electrowetting configuration that further include a section having a dielectrophoresis configuration; systems that include microfluidic devices in combination with an aqueous droplet and a fluidic medium immiscible with the aqueous droplet; related kits; and methods of manipulating droplets within the microfluidic devices.
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公开(公告)号：US20230384573A1
公开(公告)日：2023-11-30
申请号：US18447583
申请日：2023-08-10
Applicant: BERKELEY LIGHTS, INC.
Inventor： Andrew W. McFarland , Daniele Malleo , J. Tanner Nevill , Russell A. Newstrom , Keith J. Breinlinger , Paul M. Lundquist , Justin K. Valley , Jonathan Cloud Dragon Hubbard
CPC classification number: G02B21/082 , G02B27/141 , B01L3/502715 , B01L9/527 , B01L3/50273 , G01N27/44721 , G01N27/44791 , G02B21/26 , G02B21/32 , G02B21/361 , G02B27/145 , B01L2200/027 , B01L2200/0647 , B01L2300/0645 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , B01L2400/0424 , B01L2400/0427 , B01L2400/0677 , G02B19/0028
Abstract: A system for operating an electrokinetic device includes a support configured to hold and operatively couple with the electrokinetic device, an integrated electrical signal generation subsystem configured to apply a biasing voltage across a pair of electrodes in the electrokinetic device, and a light modulating subsystem configured to emit structured light onto the electrokinetic device. The system can further include a thermally controlled flow controller, and/or be configured to measure impedance across the electrokinetic device. The system can be a light microscope, including an optical train. The system can further include a light pipe, which can be part of the light modulating system, and which can be configured to supply light of substantially uniform intensity to the light modulating system or directly to the optical train.
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Patent Agency Ranking
14.发明授权公开(公告)号：US10799865B2
公开(公告)日：2020-10-13
申请号：US15336768
申请日：2016-10-27
Applicant: Berkeley Lights, Inc.
Inventor： Randall D. Lowe, Jr. , Shao Ning Pei , Jian Gong , Alexander J. Mastroianni , Jason M. McEwen , Justin K. Valley
Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode, optionally included in a cover, configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species. Also provided are microfluidic devices having an electrowetting configuration that further include a section or module having a dielectrophoresis configuration; systems that include any of the microfluidic devices in combination with an aqueous droplet and a fluidic medium immiscible with the medium of the aqueous droplet; related kits; and methods of manipulating droplets, optionally containing micro-objects such as biological cells, within the microfluidic devices.
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公开(公告)号：US20200078785A1
公开(公告)日：2020-03-12
申请号：US16509414
申请日：2019-07-11
Applicant: Berkeley Lights, Inc.
Inventor： Eric D. Hobbs , Justin K. Valley
IPC: B01L3/00 , H01L27/146 , B03C5/02 , B03C5/00
Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.
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公开(公告)号：US10350594B2
公开(公告)日：2019-07-16
申请号：US15912164
申请日：2018-03-05
Applicant: Berkeley Lights, Inc.
Inventor： Eric D. Hobbs , Justin K. Valley
IPC: G01N1/10 , G01N1/00 , G01N35/00 , G01N33/48 , B01L3/00 , B03C5/00 , B03C5/02 , H01L27/146 , H01L29/732
Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.
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公开(公告)号：US20180193835A1
公开(公告)日：2018-07-12
申请号：US15912164
申请日：2018-03-05
Applicant: Berkeley Lights, Inc.
Inventor： Eric D. Hobbs , Justin K. Valley
IPC: B01L3/00 , B03C5/00 , B03C5/02 , H01L27/146 , H01L29/732
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0819 , B01L2400/0415 , B01L2400/0424 , B03C5/005 , B03C5/026 , H01L27/14681 , H01L29/732
Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.
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公开(公告)号：US09908115B2
公开(公告)日：2018-03-06
申请号：US14961215
申请日：2015-12-07
Applicant: Berkeley Lights, Inc.
Inventor： Eric D. Hobbs , Justin K. Valley
IPC: G01N15/06 , B01L3/00 , H01L21/00 , G01N25/18 , B03C5/00 , B03C5/02 , H01L27/146 , H01L29/732
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0819 , B01L2400/0415 , B01L2400/0424 , B03C5/005 , B03C5/026 , H01L27/14681 , H01L29/732
Abstract: A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium. The base can include an array of individually controllable transistor structures each of which can comprise both a lateral transistor and a vertical transistor. The transistor structures can be light activated, and the lateral and vertical transistors can thus be photo transistors. Each transistor structure can be activated to create a temporary electrical connection from a region of the outer surface of the base (and thus fluidic medium in the enclosure) to a common electrical conductor. The temporary electrical connection can induce a localized electrokinetic force generally at the region, which can be sufficiently strong to move a nearby micro-object in the enclosure.
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