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公开(公告)号：US20230282313A1
公开(公告)日：2023-09-07
申请号：US17971400
申请日：2022-10-21
Applicant: BERKELEY LIGHTS, INC.
Inventor： Darshan Thaker , Keith J. Breinlinger , Vincent Haw Tien Pai , Christoph Andreas Neyer , Thomas M. Vetterli , Hayley M. Bennett , Elisabeth Marie Walczak , Alexander Gerald Olson , Wesley Arthur Zink , John A. Tenney , Oleksandr Tokmakov , Igor Fastnacht , Yuriy Nicheporuk , Andriy Koval , Khrystyna Andres , Alona Kostenko
CPC classification number: G16B40/20 , G16B45/00 , G16B30/20 , B01L3/502784 , G01N15/1463 , B01L2200/027
Abstract: Disclosed are methods, systems, and articles of manufacture for performing a process on biological samples. An analysis of biological samples in multiple regions of interest in a microfluidic device and a timeline correlated with the analysis may be identified. One or more region-of-interest types for the multiple regions of interest may be determined; and multiple characteristics may be determined for the biological samples based at least in part upon the one or more region-of-interest types. Associated data that respectively correspond to the multiple regions of interest in a user interface for at least a portion of the biological samples in the user interface based at least in part upon the multiple identifiers and the timeline. A count of the biological samples in a region of interest may be determined based at least in part upon a class or type of data using a convolutional neural network (CNN).
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公开(公告)号：US20210272654A1
公开(公告)日：2021-09-02
申请号：US17325196
申请日：2021-05-19
Applicant: BERKELEY LIGHTS, INC.
Inventor： Darshan Thaker , Keith J. Breinlinger , Vincent Haw Tien Pai , Christoph Andreas Neyer , Thomas M. Vetterli , Hayley M. Bennett , Elisabeth Marie Walczak , Alexander Gerald Olson , Wesley Arthur Zink , John A. Tenney , Oleksandr Tokmakov , Igor Fastnacht , Yuriy Nicheporuk , Andriy Koval , Khrystyna Andres , Alona Kostenko
Abstract: Disclosed are methods, systems, and articles of manufacture for performing a process on biological samples. An analysis of biological samples in multiple regions of interest in a microfluidic device and a timeline correlated with the analysis may be identified. One or more region-of-interest types for the multiple regions of interest may be determined; and multiple characteristics may be determined for the biological samples based at least in part upon the one or more region-of-interest types. Associated data that respectively correspond to the multiple regions of interest in a user interface for at least a portion of the biological samples in the user interface based at least in part upon the multiple identifiers and the timeline. A count of the biological samples in a region of interest may be determined based at least in part upon a class or type of data using a convolutional neural network (CNN).
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公开(公告)号：USD887296S1
公开(公告)日：2020-06-16
申请号：US29681398
申请日：2019-02-25
Applicant: BERKELEY LIGHTS, INC.
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公开(公告)号：US09744533B2
公开(公告)日：2017-08-29
申请号：US14965721
申请日：2015-12-10
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Eric D. Hobbs , Daniele Malleo , J. Tanner Nevill , Mark P. White
CPC classification number: B01L3/502761 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2300/0816 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2400/0424 , B01L2400/0427 , B01L2400/0454 , B01L2400/0457 , B01L2400/086 , G01N1/4077 , G01N2001/4083
Abstract: A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity. Methods of selectively directing the movements of micro-objects in such a microfluidic apparatus using gravitational forces are also provided. The micro-objects can be biological micro-objects, such as cells, or inanimate micro-objects, such as beads.
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公开(公告)号：US10384204B2
公开(公告)日：2019-08-20
申请号：US14963759
申请日：2015-12-09
Applicant: Berkeley Lights, Inc.
Inventor： Andrew W. McFarland , Daniele Malleo , J. Tanner Nevill , Russell A. Newstrom , Keith J. Breinlinger , Paul M. Lundquist , Justin K. Valley , Jonathan Cloud Dragon Hubbard
IPC: B01L3/00 , B01L9/00 , G02B21/08 , G02B27/14 , G01N27/447 , G02B21/26 , G02B21/32 , G02B21/36 , G02B27/09 , G02B27/10 , G02B19/00
Abstract: A system for operating an electrokinetic device includes a support configured to hold and operatively couple with the electrokinetic device, an integrated electrical signal generation subsystem configured to apply a biasing voltage across a pair of electrodes in the electrokinetic device, and a light modulating subsystem configured to emit structured light onto the electrokinetic device. The system can further include a thermally controlled flow controller, and/or be configured to measure impedance across the electrokinetic device. The system can be a light microscope, including an optical train. The system can further include a light pipe, which can be part of the light modulating subsystem, and which can be configured to supply light of substantially uniform intensity to the light modulating subsystem or directly to the optical train.
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Patent Agency Ranking
公开(公告)号：US20170355595A1
公开(公告)日：2017-12-14
申请号：US15439506
申请日：2017-02-22
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
IPC: B81B7/02 , B01L3/00 , B03C5/02 , G01N33/543 , B03C5/00 , G01N33/50 , C12M1/34 , G01N27/447
CPC classification number: B81B7/02 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2200/0668 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/087 , B01L2300/0877 , B01L2400/0424 , B01L2400/0433 , B01L2400/0454 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C7/023 , B03C2201/26 , C12M23/16 , C12M41/46 , C12M47/02 , G01N27/447 , G01N27/44756 , G01N27/44791 , G01N33/5023 , G01N33/543 , G01N33/54326 , G01N35/10
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
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公开(公告)号：US20170113231A9
公开(公告)日：2017-04-27
申请号：US14520510
申请日：2014-10-22
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
CPC classification number: B81B7/02 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2200/0668 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/087 , B01L2300/0877 , B01L2400/0424 , B01L2400/0433 , B01L2400/0454 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C7/023 , B03C2201/26 , C12M23/16 , C12M41/46 , C12M47/02 , G01N27/447 , G01N27/44756 , G01N27/44791 , G01N33/5023 , G01N33/543 , G01N33/54326 , G01N35/10
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
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公开(公告)号：US20160193604A1
公开(公告)日：2016-07-07
申请号：US14963759
申请日：2015-12-09
Applicant: Berkeley Lights, Inc.
Inventor： Andrew W. McFarland , Daniele Malleo , J. Tanner Nevill , Russell A. Newstrom , Keith J. Breinlinger , Paul M. Lundquist , Justin K. Valley , Jonathan Cloud Dragon Hubbard
CPC classification number: B01L3/50273 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/0647 , B01L2200/14 , B01L2300/06 , B01L2300/0645 , B01L2300/0654 , B01L2300/12 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427 , B01L2400/0677 , G01N27/44721 , G01N27/44791 , G02B19/0028 , G02B21/082 , G02B21/26 , G02B21/32 , G02B21/361 , G02B27/0994 , G02B27/1006 , G02B27/141 , G02B27/145
Abstract: A system for operating an electrokinetic device includes a support configured to hold and operatively couple with the electrokinetic device, an integrated electrical signal generation subsystem configured to apply a biasing voltage across a pair of electrodes in the electrokinetic device, and a light modulating subsystem configured to emit structured light onto the electrokinetic device. The system can further include a thermally controlled flow controller, and/or be configured to measure impedance across the electrokinetic device. The system can be a light microscope, including an optical train. The system can further include a light pipe, which can be part of the light modulating subsystem, and which can be configured to supply light of substantially uniform intensity to the light modulating subsystem or directly to the optical train.
Abstract translation: 一种用于操作电动装置的系统包括被配置为保持和可操作地与电动装置耦合的支撑件;被配置为在电动装置中的一对电极上施加偏置电压的集成电信号产生子系统，以及光调制子系统， 将结构光发射到电动装置上。 该系统还可以包括热控流量控制器和/或被配置成测量电动装置上的阻抗。 该系统可以是光学显微镜，包括光学列车。 该系统还可以包括光管，其可以是光调制子系统的一部分，并且其可以被配置为将光强度基本上均匀的光提供给光调制子系统或者直接提供给光学列车。
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公开(公告)号：US20150151307A1
公开(公告)日：2015-06-04
申请号：US14520510
申请日：2014-10-22
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
CPC classification number: B81B7/02 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2200/0668 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/087 , B01L2300/0877 , B01L2400/0424 , B01L2400/0433 , B01L2400/0454 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C7/023 , B03C2201/26 , C12M23/16 , C12M41/46 , C12M47/02 , G01N27/447 , G01N27/44756 , G01N27/44791 , G01N33/5023 , G01N33/543 , G01N33/54326 , G01N35/10
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
Abstract translation: 微流体装置中的保持笔中的一组微物体可以被选择并移动到分段区域，微物体可以从微流体装置输出。 微流体装置可以具有多个保持笔，并且每个保持笔可以将位于保持笔中的微物体与位于另一个保持笔中的微物体或微流体装置中的其他地方隔离。 所选择的一组微物体可以包含一个或多个生物细胞，例如克隆的细胞群。 因此，本发明的实施方案可以在微流体装置中选择特定的一组克隆细胞，将克隆细胞移动到分期区域，并从微流体装置输出克隆细胞，同时保持输出组的克隆性质。
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公开(公告)号：US12220697B2
公开(公告)日：2025-02-11
申请号：US17321974
申请日：2021-05-17
Applicant: BERKELEY LIGHTS, INC.
Inventor： Keith J. Breinlinger , Johannes Paul Sluis
Abstract: Microfluidic devices having a circuit substrate with a control unit, a switching mechanism associated with a dielectrophoresis (DEP) electrode, and a memory unit are described. Switching instructions may be received, stored, and retrieved by the control unit and used to control the DEP electrode via the switching mechanism. Systems comprising the described microfluidic devices and methods of controlling the described microfluidic devices are included herein.
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