专利检索 ap:("Bran Ferren" OR "W. Daniel Hillis" OR "Roderick A. Hyde" OR "Muriel Y. Ishikawa" OR "Edward K. Y. Jung" OR "Eric C. Leuthardt" OR "Nathan P. Myhrvold" OR "Elizabeth A. Sweeney" OR "Clarence T. Tegreene" OR "Lowell L. Wood, Jr." OR "Victoria Y. H. Wood") AND inv:"Eric C. Leuthardt" 第 2 页

11.

发明授权
Lumen-traveling biological interface device and method of use 有权

公开(公告)号：US08024036B2

公开(公告)日：2011-09-20

申请号：US12319881

申请日：2009-01-12

申请人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： A61N1/362

CPC分类号： A61B1/00156 , A61B1/00158 , A61B1/041 , A61B5/0031 , A61B5/0059 , A61B5/04001 , A61B5/05 , A61B5/07 , A61B5/14539 , A61B5/4839 , A61N1/02 , A61N1/32 , A61N1/37205

摘要： Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.

12.

发明授权
Lumen-traveling biological interface device 有权

公开(公告)号：US09801527B2

公开(公告)日：2017-10-31

申请号：US11725982

申请日：2007-03-19

申请人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： A61B1/04 , A61B1/00 , A61B10/04 , A61B17/29 , A61B17/295 , A61F2/04 , A61B34/32 , A61B34/20 , A61B34/00 , A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/03 , A61B5/04 , A61B5/145 , A61B7/00 , A61B8/12 , A61B8/00 , A61B17/22 , A61B17/3207 , A61B17/00 , A61F2/30 , A61N1/05 , A61N1/372 , A61B90/00 , A61B34/30

CPC分类号： A61B1/00156 , A61B1/00016 , A61B1/00029 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/0084 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/04 , A61B5/145 , A61B5/14539 , A61B5/415 , A61B5/418 , A61B5/4839 , A61B7/00 , A61B8/12 , A61B8/4472 , A61B8/56 , A61B10/04 , A61B17/22 , A61B17/29 , A61B17/295 , A61B17/3207 , A61B34/20 , A61B34/32 , A61B34/72 , A61B2017/00022 , A61B2017/00345 , A61B2034/2051 , A61B2034/301 , A61B2034/303 , A61B2090/064 , A61B2560/0219 , A61B2562/17 , A61F2/04 , A61F2002/30668 , A61F2002/3067 , A61F2250/0001 , A61F2250/0002 , A61F2250/0068 , A61N1/05 , A61N1/37205

摘要： Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.

13.

发明授权
Bioelectromagnetic interface system 有权
标题翻译：生物电磁接口系统

公开(公告)号：US08512219B2

公开(公告)日：2013-08-20

申请号：US11726025

申请日：2007-03-19

申请人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： A61N2/00

CPC分类号： A61B1/00156 , A61B1/00016 , A61B1/00029 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/0084 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/04 , A61B5/145 , A61B5/14539 , A61B5/415 , A61B5/418 , A61B5/4839 , A61B7/00 , A61B8/12 , A61B8/4472 , A61B8/56 , A61B10/04 , A61B17/22 , A61B17/29 , A61B17/295 , A61B17/3207 , A61B34/20 , A61B34/32 , A61B34/72 , A61B2017/00022 , A61B2017/00345 , A61B2034/2051 , A61B2034/301 , A61B2034/303 , A61B2090/064 , A61B2560/0219 , A61B2562/17 , A61F2/04 , A61F2002/30668 , A61F2002/3067 , A61F2250/0001 , A61F2250/0002 , A61F2250/0068 , A61N1/05 , A61N1/37205

摘要： Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.

摘要翻译： 描述了流明生物界面装置及相关方法和系统。能够在体腔内行进的流明的生物界面装置可以包括用于产生管腔中的内腔行进装置的运动的推进机构，用于检测生物信号的电极或其它电磁换能器以及用于传送的电极，线圈或其它电磁换能器对刺激反应组织的电磁刺激。流明生物界面装置还可以包括诸如传感器，有效部分和/或控制电路的附加部件。

14.

发明申请
Event-based control of a lumen traveling device 审中-公开
标题翻译：流明旅行装置的基于事件的控制

公开(公告)号：US20120035540A1

公开(公告)日：2012-02-09

申请号：US13136675

申请日：2011-08-05

申请人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y. H. Wood

发明人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y. H. Wood

IPC分类号： A61M25/098

CPC分类号： A61B1/041 , A61B1/00156 , A61B5/0022 , A61B5/0031 , A61B5/0071 , A61B5/01 , A61B5/02007 , A61B5/0215 , A61B5/026 , A61B5/03 , A61B5/062 , A61B5/07 , A61B5/073 , A61B5/076 , A61B5/082 , A61B5/14539 , A61B5/14546 , A61B5/4064 , A61B5/411 , A61B5/418 , A61B5/4839 , A61B5/6852 , A61B7/00 , A61B10/0045 , A61B10/04 , A61B17/22 , A61B17/22012 , A61B18/20 , A61B34/73 , A61B2010/0077 , A61B2010/0225 , A61B2017/00022 , A61B2017/00345 , A61F2/82 , A61N1/406 , A61N7/00 , G16H40/67

摘要： Methods of controlling the operation of a device traveling in a body tube tree, including selecting a direction of travel based on information relating to a previous event associated with a possible direction of travel, implemented with a control system located partially or fully on the lumen traveling device. Various actions can be performed by the device for, e.g., medical or therapeutic purposes. Machine-readable media including instructions for performing the methods are also described.

摘要翻译： 控制在体管树中行进的装置的操作的方法，包括基于与可能的行进方向相关联的先前事件相关的信息来选择行进方向，该控制系统部分或全部位于管腔行进设备。可以通过该设备执行各种动作，例如医疗或治疗目的。还描述了包括用于执行方法的指令的机器可读介质。

15.

发明申请
Map-based navigation of a body tube tree by a lumen traveling device 审中-公开
标题翻译：通过流明旅行装置的体管树的地图导航

公开(公告)号：US20120035439A1

公开(公告)日：2012-02-09

申请号：US13136678

申请日：2011-08-05

申请人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood

发明人： Bran Ferren , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood

IPC分类号： A61B5/07

CPC分类号： A61B1/041 , A61B1/00156 , A61B5/0022 , A61B5/0031 , A61B5/0071 , A61B5/01 , A61B5/02007 , A61B5/0215 , A61B5/026 , A61B5/03 , A61B5/062 , A61B5/07 , A61B5/073 , A61B5/076 , A61B5/082 , A61B5/14539 , A61B5/14546 , A61B5/4064 , A61B5/411 , A61B5/418 , A61B5/4839 , A61B5/6852 , A61B7/00 , A61B10/0045 , A61B10/04 , A61B17/22 , A61B17/22012 , A61B18/20 , A61B34/73 , A61B2010/0077 , A61B2010/0225 , A61B2017/00022 , A61B2017/00345 , A61F2/82 , A61N1/406 , A61N7/00 , G16H40/67

摘要： Method of controlling the operation of a device traveling in a body tube tree, including, determining the location of the device on a map of the body tube tree and planning a path of travel for the device toward a target location. Various actions can be performed by the device for, e.g., medical or therapeutic purposes. Machine-readable media including instructions for performing the methods are also described.

摘要翻译： 控制在体管树中行进的装置的操作的方法，包括：在体管树的地图上确定装置的位置并规划装置朝向目标位置的行进路径。可以通过该设备执行各种动作，例如医疗或治疗目的。还描述了包括用于执行方法的指令的机器可读介质。

16.

发明授权
Tubular nanostructure targeted to cell membrane 有权

公开(公告)号：US09617157B2

公开(公告)日：2017-04-11

申请号：US12322367

申请日：2009-01-30

申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： B82Y40/00 , C01B31/02 , B82Y30/00

CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915

摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

17.

发明授权
Method and apparatus for measuring the motion of a person 有权
标题翻译：用于测量人的运动的方法和装置

公开(公告)号：US09019149B2

公开(公告)日：2015-04-28

申请号：US12930043

申请日：2010-12-22

申请人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas A. Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Mahalaxmi Gita Bangera , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , David B. Tuckerman , Thomas A. Weaver , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： G01S13/00 , G06Q30/02

CPC分类号： G06Q30/02 , G06Q30/0269

摘要： One or more micro-impulse radars (MIRs) are configured to determine the movement of at least one person. Media can be output to the person responsive to the movement.

摘要翻译： 一个或多个微脉冲雷达（MIR）被配置为确定至少一个人的移动。可以将响应于移动的媒体输出给人。

18.

发明授权
Tubular nanostructure targeted to cell membrane 有权
标题翻译：管状纳米结构靶向细胞膜

公开(公告)号：US09187330B2

公开(公告)日：2015-11-17

申请号：US12283908

申请日：2008-09-15

申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood

IPC分类号： B82Y40/00 , C01B31/02 , B82Y30/00

CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915

摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.

摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。