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公开(公告)号：US07449096B2
公开(公告)日：2008-11-11
申请号：US10915744
申请日：2004-08-11
IPC分类号： G01N27/453 , B01L3/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2300/0819 , B01L2400/0421
摘要： In a system for operation or handling of a laboratory microchip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.
摘要翻译： 在用于操作或处理用于化学处理或分析的实验室微芯片（41）的系统中，微芯片（41）安装在第一物理单元（42）中。 微芯片（41）布置在安装板上，使得其从顶部容易接近，因此微芯片的装配和移除被大大简化。 此外，第一物理单元（42）包括用于非接触式检测在微芯片上进行的化学处理结果的光学装置（43）。 微芯片操作所需的供电系统被布置在与第二物理单元具有可分离连接的模块单元中。 所提出的模块化布局使得所需供应系统的可互换性变得容易，并且因此总体而言，所提出的系统适用于各种类型的微芯片。
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公开(公告)号：US6153073A
公开(公告)日：2000-11-28
申请号：US372655
申请日：1999-08-11
IPC分类号： G01N31/20 , B01L3/00 , G01N27/447 , G01N37/00 , G01N27/26
CPC分类号： B01L3/50273 , B01L3/502753 , B01L3/502784 , G01N27/44791 , B01L2200/0605 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , Y10S366/02 , Y10S366/03
摘要： The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.
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公开(公告)号：US08545771B2
公开(公告)日：2013-10-01
申请号：US13290843
申请日：2011-11-07
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44791 , B01L3/5027 , B01L2200/0636 , B01L2200/0689 , B01L2300/021 , B01L2300/0645 , B01L2300/0861 , B01L2400/0421 , G01N27/44717
摘要： The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.
摘要翻译： 本发明提供具有并入电极的流体装置。 一个设备包括卡和第一和第二球童段。 第一个扇区段包括第一和第二电极。 第二球笼段包括设置在第二段的第一表面上的第一和第二储存器，设置在第二段的第二表面上的通道以及在第一和第二表面之间延伸的第一和第二通孔。 第一个球童段连接到第二个球童段的第一个表面。 该卡被附接到第二球童段的第二表面，使得该卡为该装置提供一个封闭的表面。
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公开(公告)号：US08518327B2
公开(公告)日：2013-08-27
申请号：US13437414
申请日：2012-04-02
申请人： Colin B. Kennedy , Syed Husain , Dale von Behren , Rick Bernal
发明人： Colin B. Kennedy , Syed Husain , Dale von Behren , Rick Bernal
IPC分类号： G01N21/00
CPC分类号： G01N1/38 , G01N13/00 , G01N33/15 , G01N35/025 , G01N2013/003 , G01N2013/006 , G01N2035/00198
摘要： The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
摘要翻译： 本发明提供了用于溶出度测试的系统和方法。 该系统包括多个溶解容器和位于溶解容器上方的剂量载体。 剂量载体保持多个可移除的转盘，其接收单独的剂量以进行溶解测试。 接收片剂或沉降片的转盘通常具有第一配置，而接收篮子的转盘通常具有第二配置。 转盘的两种不同配置可在相同的剂量环上互换。 所述系统还包括位于所述剂量载体上方的驱动头，所述驱动头具有篮状心轴和可移除地且可互换地连接的混合桨。 与系统整合的移液器将样品等分试样从溶出容器转移至50ml至1ml的范围至外部容器的孔。
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公开(公告)号：US06811668B1
公开(公告)日：2004-11-02
申请号：US09595420
申请日：2000-06-15
IPC分类号： C02F140
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2300/0819 , B01L2400/0421
摘要： In a system for operation or handling of a laboratory microchip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.
摘要翻译： 在用于操作或处理用于化学处理或分析的实验室微芯片（41）的系统中，微芯片（41）安装在第一物理单元（42）中。 微芯片（41）布置在安装板上，使得其从顶部容易接近，因此微芯片的装配和移除被大大简化。 此外，第一物理单元（42）包括用于非接触式检测在微芯片上进行的化学处理结果的光学装置（43）。 微芯片操作所需的供电系统被布置在与第二物理单元具有可分离连接的模块单元中。 所提出的模块化布局使得所需供应系统的可互换性变得容易，并且因此总体而言，所提出的系统适用于各种类型的微芯片。
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公开(公告)号：US06534013B1
公开(公告)日：2003-03-18
申请号：US09504301
申请日：2000-02-15
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
IPC分类号： B01L300
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/087 , B01L2300/0816 , B01L2400/0415 , G01N27/44791
摘要： The present invention is generally directed to improved microfluidic devices and systems, and particularly to a microfluidic device which comprises a planar body structure, at least a first channel network comprising intersecting channels disposed within the body structure wherein the first channel network is contained within an area of the planar body structure that is less than about 6 cm2; and a holder assembly configured to receive the body structure, the holder assembly having at least one aperture disposed therethrough from an upper surface to a lower surface thereof, and wherein the body structure is fixedly mounted to the holder assembly.
摘要翻译： 本发明总体上涉及改进的微流体装置和系统，特别涉及一种包括平面体结构的微流体装置，至少第一通道网络包括设置在主体结构内的交叉通道，其中第一通道网络包含在一个区域内 的平面体结构小于约6cm 2; 以及保持器组件，其构造成接收所述主体结构，所述保持器组件具有从其上表面到下表面穿过其中设置的至少一个孔，并且其中所述主体结构固定地安装到所述保持器组件。
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公开(公告)号：US06100541A
公开(公告)日：2000-08-08
申请号：US30535
申请日：1998-02-24
申请人： Robert Nagle , Colin B. Kennedy
发明人： Robert Nagle , Colin B. Kennedy
CPC分类号： B01L3/5027 , B01L3/502715 , G01N21/0303 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487
摘要： The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.
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公开(公告)号：US06086740A
公开(公告)日：2000-07-11
申请号：US182827
申请日：1998-10-29
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L3/502707 , B01L9/527
摘要： Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input elements that are connected to corresponding input elements within several or each of the microfluidic modules for use in common control and/or common detection operations for each of the modules.
摘要翻译： 复数微流体装置包括多个模块化微流体元件，所有这些都是连接到共同的框架或基底上，其本身包括一个或多个公共输入元件，其连接到几个或每个微流体模块内的相应的输入元件，用于 用于每个模块的公共控制和/或常见检测操作。
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公开(公告)号：US6048498A
公开(公告)日：2000-04-11
申请号：US190428
申请日：1998-11-12
申请人： Colin B. Kennedy
发明人： Colin B. Kennedy
IPC分类号： B01L3/00 , B01L9/00 , G01N27/447
CPC分类号： B01L3/502715 , B01L9/527 , G01N27/44791 , B01L2200/025 , B01L2200/087 , B01L2300/0816 , B01L2400/0415
摘要： Microfluidic apparatus which include a planar device and polymeric holder assembly are provided. The polymeric holder assembly includes a cavity disposed through the holder, providing optical access to the top and bottom of the planar device when the device is mounted in the polymeric holder. The planar device includes microscale channels disposed within the device.
摘要翻译： 提供了包括平面装置和聚合物保持器组件的微流体装置。 聚合物保持器组件包括通过保持器设置的空腔，当该装置安装在聚合物保持器中时，提供对平面装置的顶部和底部的光学接近。 平面装置包括设置在装置内的微细通道。
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公开(公告)号：US07033474B1
公开(公告)日：2006-04-25
申请号：US09589042
申请日：2000-06-06
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487
摘要： The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.
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