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公开(公告)号：US20110259089A1
公开(公告)日：2011-10-27
申请号：US13054195
申请日：2009-07-16
IPC分类号： G01N30/02
CPC分类号： G01N30/50 , B01D15/206 , B01D15/22 , B01J2220/86 , G01N30/6095 , G01N2030/567
摘要： The present invention features devices and methods of making such devices for performing liquid chromatography having at least one wetted surface having a composition of a polysilazane.
摘要翻译： 本发明的特征在于制备这种用于进行具有至少一个具有聚硅氮烷组成的润湿表面的液相色谱装置的装置和方法。
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公开(公告)号：US20100168457A1
公开(公告)日：2010-07-01
申请号：US12447477
申请日：2007-11-06
IPC分类号： C07F7/21
CPC分类号： F04B19/006 , C08G77/16 , C08G77/26 , C08G77/388 , C08K5/09 , C08K5/544 , C08L83/04 , G01N2030/326 , G01N2030/528
摘要： High-pressure electrokinetic (“EK”) pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer- sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required.
摘要翻译： 包括混合整料的高压电动（“EK”）泵提供高表面电荷密度和具有微米尺寸通孔的连续稳定的骨架形态。 与具有等效机械稳定性的现有技术的整料相比，本发明的混合整料具有优异的机械强度和更好的稳定性。 可以通过使用不同的化学试剂来改变和/或制备稳定的混合整料的表面电荷。 化学试剂和对整料的所得改性用于将混合整料的有用性扩展到各种泵送应用，包括基于芯片的系统和需要泵送酸性溶液的能力的其它应用。
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13.发明申请Methods, Compositions and Devices For Performing Ionization Desorption on Silicon Derivatives 审中-公开用于在硅衍生物上进行电离解吸的方法，组合物和装置公开(公告)号：US20080305555A1
公开(公告)日：2008-12-11
申请号：US12063093
申请日：2006-08-16
CPC分类号： H01J49/04 , B01L3/5085 , Y10T436/24
摘要： A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface.
摘要翻译： 用于呈现用于MALDI或DIOS离子源的样品的装置，包括具有至少一个第一表面和至少一个第二表面的半导体晶片体，所述第一表面经化学修饰以将所述水性样品排斥到所述第二表面。
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14.发明授权Device for solid phase extraction and method for purifying samples prior to analysis 有权固相萃取装置和分析前样品的纯化方法公开(公告)号：US07192525B2
公开(公告)日：2007-03-20
申请号：US11393076
申请日：2006-03-30
申请人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond P. Fisk , Pamela Carmen Iraneta , Yuri Tuvim , Edouard S. P. Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D15/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译： 固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于第一过滤器的第二过滤器，该第二过滤器位于吸附剂颗粒床之下的井内以及排出口上方。 还提供了使用该装置执行SPE的方法。
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公开(公告)号：US06952011B2
公开(公告)日：2005-10-04
申请号：US10223401
申请日：2002-08-19
申请人： Jeff Brown , Dominic Gostick , Edouard S. P. Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
发明人： Jeff Brown , Dominic Gostick , Edouard S. P. Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
CPC分类号： H01J49/0418 , B01L3/5088
摘要： A MALDI sample plate 1 is disclosed which comprises a metallic substrate 2 having a circular groove or moat 3. A hydrophobic polytetrafluoroethylene layer 4 is applied to the substrate 2 and a central portion 5 of the substrate 2 is laser etched which roughens the surface of the substrate 2. A thin polystyrene layer is then applied to the polytetrafluoroethylene layer 4 and the central portion 5.
摘要翻译： 公开了一种MALDI样品板1，其包括具有圆形凹槽或护城河3的金属基底2。 将疏水性聚四氟乙烯层4施加到基板2上，对基板2的中心部5进行激光蚀刻，使基板2的表面粗糙化。 然后将薄聚苯乙烯层施加到聚四氟乙烯层4和中心部分5。
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公开(公告)号：US5976367A
公开(公告)日：1999-11-02
申请号：US216047
申请日：1998-12-18
CPC分类号： G01N30/482 , B01D15/00 , B01D15/08 , B01J20/285 , B01J2220/54 , B01J2220/62 , B01J2220/64
摘要： A method for removing an organic solute from a solution, comprising contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.
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公开(公告)号：US08680311B2
公开(公告)日：2014-03-25
申请号：US12447477
申请日：2007-11-06
IPC分类号： C07F7/00
CPC分类号： F04B19/006 , C08G77/16 , C08G77/26 , C08G77/388 , C08K5/09 , C08K5/544 , C08L83/04 , G01N2030/326 , G01N2030/528
摘要： High-pressure electrokinetic (“EK”) pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer-sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required.
摘要翻译： 包括混合整料的高压电动（“EK”）泵提供高表面电荷密度和具有微米尺寸通孔的连续稳定的骨架形态。 与具有等效机械稳定性的现有技术的整料相比，本发明的混合整料具有优异的机械强度和更好的稳定性。 可以通过使用不同的化学试剂来改变和/或制备稳定的混合整料的表面电荷。 化学试剂和对整料的所得改性用于将混合整料的有用性扩展到各种泵送应用，包括基于芯片的系统和需要泵送酸性溶液的能力的其它应用。
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公开(公告)号：US07294831B2
公开(公告)日：2007-11-13
申请号：US11196820
申请日：2005-08-03
申请人： Jeff Brown , Dominic Gostick , Edouard S. P. Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
发明人： Jeff Brown , Dominic Gostick , Edouard S. P. Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
IPC分类号： H01J49/04
CPC分类号： H01J49/0418 , B01L3/5088
摘要： A MALDI sample plate 1 is disclosed which comprises a metallic substrate 2 having a circular groove or moat 3. A hydrophobic polytetrafluoroethylene layer 4 is applied to the substrate 2 and a central portion 5 of the substrate 2 is laser etched which roughens the surface of the substrate 2. A thin polystyrene layer is then applied to the polytetrafluoroethylene layer 4 and the central portion 5.
摘要翻译： 公开了一种MALDI样品板1，其包括具有圆形凹槽或护城河3的金属基底2。 将疏水性聚四氟乙烯层4施加到基板2上，对基板2的中心部5进行激光蚀刻，使基板2的表面粗糙化。 然后将薄聚苯乙烯层施加到聚四氟乙烯层4和中心部分5。
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公开(公告)号：US06726842B2
公开(公告)日：2004-04-27
申请号：US10235608
申请日：2002-09-05
IPC分类号： B01D1508
CPC分类号： G01N30/482 , B01D15/00 , B01D15/08 , B01J20/285 , B01J2220/54 , B01J2220/62 , B01J2220/64
摘要： A method for removing an organic solute from a solution, comprising contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.
摘要翻译： 一种从溶液中除去有机溶质的方法，包括使溶液与通过共聚一种或多种疏水单体和一种或多种亲水单体形成的聚合物接触，由此将溶质吸附到聚合物上。 溶液可以包含极性溶剂如极性有机溶剂或水或水性缓冲液。 疏水性单体可以是例如二乙烯基苯。 亲水性单体可以是例如杂环单体，例如乙烯基吡啶或N-乙烯基吡咯烷酮。
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20.发明授权Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices 有权用于窄孔毛细管或微流体装置的流体流量控制冻结/解冻阀公开(公告)号：US06557575B1
公开(公告)日：2003-05-06
申请号：US09997491
申请日：2001-11-19
IPC分类号： F16K4900
CPC分类号： F16K13/10 , B01L3/502738 , B01L2400/0677 , F16L55/103 , G01N30/20 , G01N30/6004 , G01N30/6065 , G01N2030/3038 , G01N2030/6008 , G01N2035/00267 , Y10T137/0391 , Y10T137/2196 , Y10T137/4643 , G01N30/30
摘要： Methods and devices for the management of fluid flow within nanoscale analytical systems, comprising a freeze thaw valve having differing geomentries to constrict a frozen plug within the freeze thaw segment. The freeze thaw valve is directed to use in high-pressure analytical systems. The geometry of an inner diameter of a channel or tube within a freeze thaw segment is configured to cause constriction of a freeze plug when axial force is applied. The constriction is used in the flow-path of a freeze thaw valve to prevent movement of the frozen plug at high pressures to avoid valve leakage.
摘要翻译： 用于管理纳米级分析系统内的流体流动的方法和装置，包括具有不同的几何形状的冻融阀，以收缩冻融段内的冷冻塞。 冷冻解冻阀用于高压分析系统。 冻融段内的通道或管的内径的几何形状构造成当施加轴向力时引起冷冻塞的收缩。 在冷冻解冻阀的流路中使用收缩部，以防止冷冻塞在高压下移动，以避免阀泄漏。
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