利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.036 秒)

    Universal programmable process control apparatus
    11.
    发明授权
    Universal programmable process control apparatus 失效
    通用可编程控制装置

    公开(公告)号：US4102492A

    公开(公告)日：1978-07-25

    申请号：US819875

    申请日：1977-07-28

    申请人： Joseph Gold ,  Frank Farese

    发明人： Joseph Gold ,  Frank Farese

    IPC分类号： G05B19/02 ,  G05B19/045 ,  G05B19/12 ,  G06K15/00 ,  G05B5/00 ,  G06F7/38 ,  H01H43/08

    CPC分类号： G05B19/045 ,  G05B19/124

    摘要： Apparatus for selectively enabling and disabling a process depending on the instantaneous value of a measurement made during the process in accordance with a predetermined program recorded by shading adjacent segments on an area of a record means the length of which is an analog of the total range of the measurement with each of the segments representing an interval of the measurement during which the process is to be enabled or disabled. A plurality of memory cores in one to one correspondence with subsegments of the measurement range analog are caused during programming to occupy one of two bistable states in response to a light sensor responsive to the light originating from an incident source and reflected by the program record. After programming, the memory cores are interrogated in accordance with the instantaneous value of measurement and a process control switch is set to a state corresponding to the state of the last interrogated memory core.

    摘要翻译： 一种装置，用于根据在该过程期间所做的测量的瞬时值来选择性地启用和禁用一个过程，该预定程序是通过在记录装置的一个区域上的相邻区域上的阴影相隔而记录的预定程序，其长度是 每个段的测量表示在该过程被启用或禁用期间的测量间隔。 响应于响应于源自入射源并被程序记录反射的光的光传感器，在编程期间引起与测量范围模拟的子段一一对应的多个存储器核心，以占据两个双稳态之一。 在编程之后，根据测量的瞬时值询问存储器核心，并且将过程控制开关设置为与最后被询问的存储器核心的状态相对应的状态。

    Selective antibody targeting of undifferentiated stem cells
    14.
    发明申请
    Selective antibody targeting of undifferentiated stem cells 审中-公开
    未分化干细胞的选择性抗体靶向

    公开(公告)号：US20070202596A1

    公开(公告)日：2007-08-30

    申请号：US11710864

    申请日：2007-02-26

    申请人： Jim McWhir ,  Joseph Gold ,  J. Schiff

    发明人： Jim McWhir ,  Joseph Gold ,  J. Schiff

    IPC分类号： C12N5/08 ,  C12N5/00

    CPC分类号： C12N9/1276 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0606 ,  C12N9/1048 ,  C12N2502/13 ,  C12N2510/00 ,  C12N2799/022 ,  C12Y204/01087

    摘要： This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in expression of a cell-surface antigen that can be used to deplete the undifferentiated cells. Model effector sequences encode glycosyl transferases that synthesize carbohydrate xenoantigen or alloantigen, which can be used for immunoseparation or as a target for complement-mediated lysis. The differentiated cell populations produced are suitable for use in tissue regeneration and non-therapeutic applications such as drug screening.

    摘要翻译： 本发明提供了一种用于从干细胞群体产生分化细胞的系统，用于需要相对均匀细胞群体的地方。 细胞含有在转录控制元件（例如TERT启动子）的控制下的效应基因，其导致基因在群体中相对未分化的细胞中表达。 效应基因的表达导致可用于消耗未分化细胞的细胞表面抗原的表达。 模型效应序列编码糖基转移酶，其合成碳水化合物异种抗原或同种异体抗原，其可用于免疫分离或作为补体介导的裂解的靶标。 产生的分化细胞群体适用于组织再生和非治疗应用，如药物筛选。

    Differentiated cells suitable for human therapy
    15.
    发明申请
    Differentiated cells suitable for human therapy 有权
    分化细胞适合人类治疗

    公开(公告)号：US20060134782A1

    公开(公告)日：2006-06-22

    申请号：US11359341

    申请日：2006-02-21

    申请人： Joseph Gold ,  Jane Lebkowski

    发明人： Joseph Gold ,  Jane Lebkowski

    IPC分类号： C12N5/08

    CPC分类号： C12N15/85 ,  A61K35/12 ,  C12N5/0606 ,  C12N2502/13 ,  C12N2510/00

    摘要： This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in depletion of undifferentiated cells, or expression of a marker that can be used to remove them later. Suitable effector sequences encode a toxin, a protein that induces apoptosis; a cell-surface antigen, or an enzyme (such as thymidine kinase) that converts a prodrug into a substance that is lethal to the cell. The differentiated cell populations produced according to this disclosure are suitable for use in tissue regeneration, and non-therapeutic applications such as drug screening.

    摘要翻译： 本发明提供了一种用于从干细胞群体产生分化细胞的系统，用于需要相对均匀细胞群体的地方。 细胞含有在转录控制元件（例如TERT启动子）的控制下的效应基因，其导致基因在群体中相对未分化的细胞中表达。 效应基因的表达导致未分化细胞的消耗或可以用于稍后去除它们的标记物的表达。 合适的效应序列编码毒素，诱导细胞凋亡的蛋白质; 细胞表面抗原或将前药转化为对细胞致死的物质的酶（例如胸苷激酶）。 根据本公开生产的分化细胞群体适用于组织再生和非治疗应用，例如药物筛选。

    Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
    16.
    发明申请
    Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function 审中-公开
    心脏体：用于再生心脏功能的自发收缩细胞簇

    公开(公告)号：US20050214938A1

    公开(公告)日：2005-09-29

    申请号：US11085899

    申请日：2005-03-21

    申请人： Joseph Gold ,  Chunhui Xu

    发明人： Joseph Gold ,  Chunhui Xu

    IPC分类号： C12N5/077 ,  C12N5/08

    CPC分类号： C12N5/0657 ,  C12N2500/33 ,  C12N2501/33 ,  C12N2506/02 ,  C12N2533/50 ,  C12N2533/90

    摘要： This disclosure describes clusters of cardiomyocyte lineage cells referred to as cardiac bodies. They can be obtained by differentiating human embryonic stem cells into cells that express cardiomyocyte markers, and separating cells according to their density. Single suspended cells are removed, leaving self-aggregating clusters that can be propagated and enriched in further separation steps. The resulting cardiac bodies express cardiomyocyte markers at levels ˜100-fold above the starting cell population, and undergo spontaneous periodic contraction. The clusters can be used intact or dispersed into single-cell suspensions for use in research, drug screening or the preparation of pharmaceutical compositions for the treatment of cardiac disease.

    摘要翻译： 本公开描述了称为心脏体的心肌细胞谱系细胞簇。 它们可以通过将人胚胎干细胞分化成表达心肌细胞标记的细胞，并根据其密度分离细胞来获得。 去除单个悬浮细胞，留下可以进一步分离步骤繁殖和富集的自聚集簇。 所产生的心脏体表达高于起始细胞群高100倍的心肌细胞标志物，并经历自发性周期性收缩。 这些簇可以完整使用或分散在单细胞悬浮液中，用于研究，药物筛选或用于治疗心脏病的药物组合物的制备。

    Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
    19.
    发明申请
    Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells 有权
    灵长类动物多能干细胞分化为心肌细胞谱系细胞

    公开(公告)号：US20070010012A1

    公开(公告)日：2007-01-11

    申请号：US11471916

    申请日：2006-06-20

    申请人： Joseph Gold ,  Mohammad Hassanipour

    发明人： Joseph Gold ,  Mohammad Hassanipour

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0657 ,  C12N2500/90 ,  C12N2501/105 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2506/02 ,  C12N2533/54

    摘要： The present application describes the new methods for the differentiation of primate pluripotent stem cells into cardiomyocyte-lineage cells. The methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce cardiomyocyte-lineage cells. In certain embodiments of the invention, the population of cells produced by the sequential culturing is further enriched for cardiomyocyte-lineage cells so as to produce a higher percentage of those cells.

    摘要翻译： 本申请描述了将灵长动物多能干细胞分化为心肌细胞谱系细胞的新方法。 该方法利用灵长动物多能干细胞在某些生长因子中的顺序培养来产生心肌细胞谱系细胞。 在本发明的某些实施方案中，通过顺序培养产生的细胞群进一步富集心肌细胞谱系细胞，从而产生较高百分比的这些细胞。