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公开(公告)号：US07619067B2
公开(公告)日：2009-11-17
申请号：US11383798
申请日：2006-05-17
申请人： Madan M. Paidhungat , Ian J. Sas , Thomas Bouquin , David Lin , Teddy Chen , Douglas Guptill , Amy Brideau-Andersen , Steven H. Bass , Phillip A. Patten
发明人： Madan M. Paidhungat , Ian J. Sas , Thomas Bouquin , David Lin , Teddy Chen , Douglas Guptill , Amy Brideau-Andersen , Steven H. Bass , Phillip A. Patten
摘要： The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译： 本发明提供了进化型干扰素-α多肽及其缀合物，以及编码多肽的核酸。 本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。
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公开(公告)号：US06541011B2
公开(公告)日：2003-04-01
申请号：US09247890
申请日：1999-02-10
IPC分类号： A61K3912
CPC分类号： C40B40/02 , A61K39/00 , A61K39/0011 , A61K39/015 , A61K39/0225 , A61K39/0258 , A61K39/0291 , A61K39/085 , A61K39/105 , A61K39/107 , A61K39/12 , A61K39/35 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/62 , C12N2710/16634 , C12N2730/10134 , C12N2740/16134 , C12N2760/12134 , C12N2770/24134 , C12N2770/24234 , C12N2770/36134 , Y02A50/472 , Y02A50/474
摘要： This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及抗原文库免疫，其提供获得治疗和其它用途具有改进性质的抗原的方法。 该方法可用于获得可诱导针对病原体，癌症和其它病症的免疫应答的改良抗原以及有效调节过敏，炎症和自身免疫性疾病的抗原。
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13.发明授权Polynucleotides encoding flavivirus and alphavirus multivalent antigenic polypeptides 失效编码黄病毒和甲病毒多价抗原多肽的多核苷酸公开(公告)号：US06576757B1
公开(公告)日：2003-06-10
申请号：US09724852
申请日：2000-11-28
IPC分类号： C07H2104
CPC分类号： C40B40/02 , A61K39/00 , A61K39/0011 , A61K39/015 , A61K39/0225 , A61K39/0258 , A61K39/0291 , A61K39/085 , A61K39/105 , A61K39/107 , A61K39/12 , A61K39/35 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/62 , C12N2710/16634 , C12N2730/10134 , C12N2740/16134 , C12N2760/12134 , C12N2770/24134 , C12N2770/24234 , C12N2770/36134 , Y02A50/472 , Y02A50/474
摘要： This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及抗原文库免疫，其提供获得治疗和其它用途具有改进性质的抗原的方法。 该方法可用于获得可诱导针对病原体，癌症和其它病症的免疫应答的改良抗原以及有效调节过敏，炎症和自身免疫性疾病的抗原。
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公开(公告)号：US06569435B1
公开(公告)日：2003-05-27
申请号：US09724969
申请日：2000-11-28
IPC分类号： A61K3912
CPC分类号： C40B40/02 , A61K39/00 , A61K39/0011 , A61K39/015 , A61K39/0225 , A61K39/0258 , A61K39/0291 , A61K39/085 , A61K39/105 , A61K39/107 , A61K39/12 , A61K39/35 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/62 , C12N2710/16634 , C12N2730/10134 , C12N2740/16134 , C12N2760/12134 , C12N2770/24134 , C12N2770/24234 , C12N2770/36134 , Y02A50/472 , Y02A50/474
摘要： This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及抗原文库免疫，其提供获得治疗和其它用途具有改进性质的抗原的方法。 该方法可用于获得可诱导针对病原体，癌症和其它病症的免疫应答的改良抗原以及有效调节过敏，炎症和自身免疫性疾病的抗原。
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15.发明申请公开(公告)号：US20120252681A1
公开(公告)日：2012-10-04
申请号：US13310332
申请日：2011-12-02
申请人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C40B10/00
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译： 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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公开(公告)号：US08029988B2
公开(公告)日：2011-10-04
申请号：US11987555
申请日：2007-11-30
申请人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P. C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , Jon E. Ness , Claes Gustafsson , Phillip A. Patten
CPC分类号： C12P21/06
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
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公开(公告)号：US07629170B2
公开(公告)日：2009-12-08
申请号：US11506215
申请日：2006-08-17
申请人： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC分类号： C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US06287862B1
公开(公告)日：2001-09-11
申请号：US09626410
申请日：2000-07-26
申请人： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus M. Krebber , Steven H. Bass
发明人： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda Castle , Claus M. Krebber , Steven H. Bass
IPC分类号： C12N1500
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US08377681B2
公开(公告)日：2013-02-19
申请号：US13310332
申请日：2011-12-02
申请人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US20100184627A1
公开(公告)日：2010-07-22
申请号：US12557829
申请日：2009-09-11
申请人： Andreas Crameri , Willem P.C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , John E. Ness , Claes Gustafsson , Phillip A. Patten
发明人： Andreas Crameri , Willem P.C. Stemmer , Jeremy Minshull , Steven H. Bass , Mark Welch , John E. Ness , Claes Gustafsson , Phillip A. Patten
IPC分类号： C40B50/00
CPC分类号： C12P21/06
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
摘要翻译： 提供重组核酸的方法，包括同源核酸。 还提供了基因改组寡核苷酸家族及其在重组过程中的应用，以及聚合酶和连接酶介导的重组方法。
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