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    DEVICES FOR SURGICAL APPLICATIONS
    11.
    发明申请
    DEVICES FOR SURGICAL APPLICATIONS 审中-公开
    手术应用装置

    公开(公告)号：US20130030452A1

    公开(公告)日：2013-01-31

    申请号：US13558483

    申请日：2012-07-26

    申请人： Joseph ITSKOVITZ-ELDOR ,  Eyal Zussman ,  Lior Lowenstein ,  Naama Zeevi-Levin ,  Liron Eldor

    发明人： Joseph ITSKOVITZ-ELDOR ,  Eyal Zussman ,  Lior Lowenstein ,  Naama Zeevi-Levin ,  Liron Eldor

    IPC分类号： A61B17/03

    CPC分类号： A61L27/34 ,  A61F2/0063 ,  A61L27/50 ,  A61L2420/02 ,  A61L2430/34

    摘要： Provided is a device comprising at least two layers, said at least two layers being at least partially overlapping (e.g., superposed) and contacting one another, wherein a first layer of said at least two layers comprises a non-biodegradable mesh, and wherein a second layer of the at least two layers comprises an electrospun element, and wherein the device is devoid of an extracellular matrix generated by mesenchymal progenitor cells, which are characterized by a reduced differentiation potential into an adipogenic lineage by at least about 50% as compared to differentiation potential of mesenchymal stem cells from an adult adipose source under identical assay conditions, and by an increased osteogenic differentiation potential by at least about 20% as compared to the osteogenic differentiation potential of adipose-derived MSCs under identical assays conditions.

    摘要翻译： 提供了一种包括至少两层的装置，所述至少两层至少部分重叠（例如重叠）并彼此接触，其中所述至少两层的第一层包括不可生物降解的网，并且其中 所述至少两层的第二层包含电纺丝元件，并且其中所述装置没有由间充质祖细胞产生的细胞外基质，其特征在于与脂肪形成谱系分化潜力降低至少约50％，与 在相同的测定条件下，来自成年脂肪源的间充质干细胞的分化潜能以及在相同测定条件下与脂肪来源的MSC的成骨分化潜能相比，成骨分化潜能增加至少约20％。

    NONWOVEN STRUCTURE AND METHOD OF FABRICATING THE SAME
    14.
    发明申请
    NONWOVEN STRUCTURE AND METHOD OF FABRICATING THE SAME 审中-公开
    非织造结构及其制造方法

    公开(公告)号：US20110082565A1

    公开(公告)日：2011-04-07

    申请号：US12996776

    申请日：2009-06-08

    申请人： Roey Tzezana ,  Shulamit Levenberg ,  Eyal Zussman

    发明人： Roey Tzezana ,  Shulamit Levenberg ,  Eyal Zussman

    IPC分类号： A61F2/02 ,  B32B7/02 ,  D04H3/02 ,  B32B37/16

    CPC分类号： D01D5/0046 ,  A61L27/14 ,  A61L27/38 ,  D04H1/728 ,  Y10T156/10

    摘要： A method for fabricating a nonwoven structure is disclosed. The method comprises: forming a nonwoven layer of polymer fibers on the collector liquid surface, transferring the layer to a solid surface, and repeating the formation and the transfer in a layerwise manner. The method is generally effected by spinning liquefied polymer, in particular by employing electrostatic or hydrostatic forces. The nonwoven structure formed comprises of plurality of nonwoven layers: the average thickness of the nonwoven structure is at least 0.5 mm and the structure has an overall porosity of at least 90%. The nonwoven structure an be used in forming a scaffold for tissue engineering, in particular a cell-scaffold composition, suitable for implanting in a patient, wherein at least one cell population is seeded on at least one of the plurality of layers.

    摘要翻译： 公开了一种用于制造非织造结构的方法。 该方法包括：在收集器液体表面上形成聚合物纤维的非织造层，将层转移到固体表面，并以分层方式重复形成和转移。 该方法通常通过旋转液化聚合物，特别是通过使用静电或静水力来实现。 形成的非织造结构包括多个非织造层：非织造结构的平均厚度至少为0.5mm，并且该结构的总孔隙率至少为90％。 非织造结构用于形成组织工程用支架，特别是适用于植入患者的细胞支架组合物，其中至少一个细胞群体接种在多个层中的至少一个层上。

    Electrospun Scaffolds And Methods Of Generating And Using Same
    20.
    发明申请
    Electrospun Scaffolds And Methods Of Generating And Using Same 有权
    电纺脚手架及其使用方法

    公开(公告)号：US20100172952A1

    公开(公告)日：2010-07-08

    申请号：US12449262

    申请日：2008-01-31

    申请人： Samer Srouji ,  Eyal Zussman ,  Erella Livne

    发明人： Samer Srouji ,  Eyal Zussman ,  Erella Livne

    IPC分类号： A61K33/42 ,  A61F2/00 ,  A61K35/12 ,  A61P19/00 ,  A61P43/00

    CPC分类号： A61L27/56 ,  A61L27/46 ,  A61L2400/12 ,  Y10S977/795 ,  C08L67/04

    摘要： A porous scaffold is disclosed, the porous scaffold comprising electrospun polymeric nanofibers, wherein an average diameter of a pore of the porous scaffold is about 300 μm is disclosed. An average diameter of the polymeric nanofibers ranges from about 100 to 400 nm. The scaffold may comprise a plurality of particles, the particles being greater than about 1 μm in diameter. Methods of fabricating scaffolds, methods for generating tissue and methods of using scaffolds for tissue reconstruction are also disclosed.

    摘要翻译： 公开了多孔支架，所述多孔支架包括电纺聚合物纳米纤维，其中所述多孔支架的孔的平均直径为约300μm。 聚合物纳米纤维的平均直径为约100至400nm。 支架可以包括多个颗粒，颗粒直径大于约1μm。 还公开了制造支架的方法，用于产生组织的方法和使用支架用于组织重建的方法。