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11.发明申请公开(公告)号：US20060089334A1
公开(公告)日：2006-04-27
申请号：US10505257
申请日：2003-02-27
申请人： Richard Budhu , George Doherty , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway
发明人： Richard Budhu , George Doherty , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway
IPC分类号： A61K31/433 , A61K31/426 , A61K31/4245 , A61K31/421 , A61K31/4172 , A61K31/4152
CPC分类号： C07D257/04 , C07C229/34 , C07C309/24 , C07C311/51 , C07D233/84 , C07D249/04 , C07D249/12 , C07D257/06 , C07F9/094 , C07F9/3808 , C07F9/3826 , C07F9/3882
摘要： The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译： 本发明包括化合物或式（I）：及其药学上可接受的盐和水合物。 该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。 包括药物组合物和使用方法。
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12.发明授权Device and method for nonclinical monitoring of breathing during sleep, control of CPAP treatment and preventing apnea 失效睡眠期间非临床监测呼吸的装置和方法，控制CPAP治疗和预防呼吸暂停公开(公告)号：US06398739B1
公开(公告)日：2002-06-04
申请号：US09365643
申请日：1999-08-02
IPC分类号： A61B508
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patient may operate a CPAP system to deliver appropriate airway pressure home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译： 患者可以操作CPAP系统以在家中提供适当的气道压力。 患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。
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公开(公告)号：US06248755B1
公开(公告)日：2001-06-19
申请号：US09542617
申请日：2000-04-04
申请人： Kevin Chapman , Jeffrey Hale , Dooseop Kim , Christopher Lynch , Shrenik Shah , Kothandaraman Shankaran , Dong-Ming Shen , Christopher Willoughby , Malcolm MacCoss , Sander G. Mills , Jennifer L. Loebach , Ravindra N. Guthikonda
发明人： Kevin Chapman , Jeffrey Hale , Dooseop Kim , Christopher Lynch , Shrenik Shah , Kothandaraman Shankaran , Dong-Ming Shen , Christopher Willoughby , Malcolm MacCoss , Sander G. Mills , Jennifer L. Loebach , Ravindra N. Guthikonda
IPC分类号： A61K3150
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R14 and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I的吡咯烷化合物（其中R 1，R 2，R 3，R 4，R 5，R 6，R 14和n如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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公开(公告)号：US20070119454A1
公开(公告)日：2007-05-31
申请号：US11698894
申请日：2007-01-29
CPC分类号： A61M16/06 , A61M16/0069 , A61M16/022 , A61M16/0616 , A61M16/0633 , A61M16/0677 , A61M16/0683 , A61M16/08 , A61M16/0825 , A61M16/0833 , A61M16/0858 , A61M16/1045 , A61M2016/0039 , A61M2210/0618
摘要： A patient interface assembly adapted to be connected to a gas supply pump to deliver pressurized breathable gas to the inlet of a patient's respiratory system includes a patient interface structured to provide a seal with the patient and at least one inlet tube provided to the patient interface. Each inlet tube includes a substantially flat lower side wall to face the patient and a substantially arcuate upper side wall.
摘要翻译： 适于连接到气体供应泵以将加压的可呼吸气体输送到患者呼吸系统的入口的患者接口组件包括构造成向患者提供密封的患者接口以及提供给患者接口的至少一个入口管。 每个入口管包括面向患者的基本平坦的下侧壁和基本上弓形的上侧壁。
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公开(公告)号：US07004908B2
公开(公告)日：2006-02-28
申请号：US10050163
申请日：2002-01-18
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem ca be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
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公开(公告)号：US20050033055A1
公开(公告)日：2005-02-10
申请号：US10500895
申请日：2003-01-15
申请人： Robert Bugianesi , George Doherty , Amy Gentry , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway III
发明人： Robert Bugianesi , George Doherty , Amy Gentry , Jeffrey Hale , Christopher Lynch , Sander Mills , William Neway III
IPC分类号： A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4245 , A61K31/675 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/06 , A61P27/02 , A61P27/12 , A61P29/00 , A61P31/14 , A61P31/20 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , C07D205/04 , C07D207/16 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/14 , C07F9/572 , C07F9/6558 , C07F9/547 , C07D207/08 , C07D211/34
CPC分类号： C07D403/04 , C07D205/04 , C07D207/16 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/14 , C07F9/572 , C07F9/65586
摘要： The present invention encompasses compounds of Formula 1: as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译： 本发明包括式1的化合物及其药学上可接受的盐和水合物。 该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。 包括药物组合物和使用方法。
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17.发明授权Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient 失效用于诊断患者阻塞性睡眠呼吸暂停的方法和装置公开(公告)号：US06635021B1
公开(公告)日：2003-10-21
申请号：US08934176
申请日：1997-09-19
IPC分类号： A61B508
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CPAP system to deliver appropriate airway pressure at their home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译： 患者可以运用CPAP系统在家中提供适当的气道压力。 患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。
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18.发明授权Device and method for treating obstructed breathing having a delay/ramp feature 失效用于治疗具有延迟/斜坡特征的阻塞呼吸的装置和方法
公开(公告)号：US5522382A
公开(公告)日：1996-06-04
申请号：US371083
申请日：1995-01-10
IPC分类号： A61B5/097 , A61B7/00 , A61F5/56 , A61M16/00 , A61M16/06 , A62B7/00 , A61B5/08 , A62B7/04 , F16K31/02
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： An air flow device and a method useful for the treatment of upper airway disordered breathing. The invention provides an airflow device having a means for delivering variable pressure levels of breathable air to a patient's respiratory system with a means for controlling the time during which the delivered pressurized air rises from an initial pressure level to a higher operating pressure level. The device increases the pressure level of gas delivered to the patient over a plurality of breaths taken by the patient. This type of device is useful for treating a wide variety of sleeping and breathing disorders.
摘要翻译： 一种气流装置和用于治疗上呼吸道呼吸紊乱的方法。 本发明提供了一种气流装置，其具有用于将输送可变压力水平的透气空气传送到患者呼吸系统的装置，该装置具有用于控制输送的加压空气从初始压力水平升高到较高工作压力水平的时间的装置。 该装置增加了由患者采取的多次呼吸输送到患者的气体的压力水平。 这种类型的装置可用于治疗各种睡眠和呼吸障碍。
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公开(公告)号：US20070015787A1
公开(公告)日：2007-01-18
申请号：US11491851
申请日：2006-07-24
申请人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号： A61K31/4745 , A61K31/4412 , A61K31/277 , A61K31/198 , A61K31/18
CPC分类号： C07D233/06 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/36 , C07D277/74 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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20.发明授权Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient 失效用于诊断患者阻塞性睡眠呼吸暂停的方法和装置公开(公告)号：US07141021B2
公开(公告)日：2006-11-28
申请号：US11186695
申请日：2005-07-21
IPC分类号： A61B5/08
CPC分类号： A61B5/097 , A61B5/6814 , A61B7/003 , A61F5/56 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M2016/0024 , A61M2016/0036 , A61M2230/04 , A61M2230/10 , A61M2230/18 , A61M2230/205 , A61M2230/432 , A61M2230/60
摘要： Patients may operate a CAP system to deliver appropriate airway pressure at their home. A patient's apnea problem can be diagnosed at home without supervision with a CPAP device which delivers a continuously minimum appropriate pressure for substantially the entire period of therapy.
摘要翻译： 患者可以操作CAP系统，在家中提供适当的气道压力。 患者的呼吸暂停问题可以在家中进行诊断，而不用CPAP设备进行监督，CPAP设备在大体上整个治疗期间都能持续提供适当的压力。
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