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公开(公告)号：US08862235B1
公开(公告)日：2014-10-14
申请号：US11983674
申请日：2007-11-09
申请人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
发明人： Howard H. Stover , John C. Gord , Charles L. Byers , Joseph H. Schulman , Guangqiang Jiang , Ross Davis
CPC分类号： A61B5/0478 , A61B5/0006 , A61B5/04012 , A61B5/686 , A61N1/36003 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36082
摘要： A brain implant device includes a housing containing communication and control electronics coupled to a conduit configured for monitoring signals from a brain's motor cortex and providing stimulation signals to the brain's sensory cortex. The brain implant device is capable of wireless communication with an external communication and control signal source by means of an antenna provided in the housing. The conduit is flexible and may contain upwards of 128 electrical conductors providing electrical connections between the device electronics and related sites on the motor and/or sensory cortex by means of a plurality of electrically conductive protuberances extending from the conduit and adapted for contact with such sites.
摘要翻译： 脑植入装置包括壳体，其包含耦合到导管的通信和控制电子器件，所述导管被配置用于监测来自大脑的运动皮质的信号并向大脑的感觉皮质提供刺激信号。 脑植入装置能够通过设置在壳体中的天线与外部通信和控制信号源进行无线通信。 导管是柔性的并且可以包含上部128个电导体，其借助于从导管延伸并适于与这些部位接触的多个导电突起，在装置电子设备和电动机和/或感觉皮质之间的相关部位提供电连接 。
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公开(公告)号：US08336191B1
公开(公告)日：2012-12-25
申请号：US11833887
申请日：2007-08-03
IPC分类号： H04R31/00
CPC分类号： H03H9/54 , H01L2224/48227 , H01L2224/48465 , H03H9/1021 , H05K13/04 , Y10T29/49005 , Y10T29/49007 , Y10T29/4908 , H01L2924/00
摘要： An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.
摘要翻译： 电子滤波器电路包括直接安装到硅集成电路的表面的机电谐振器，而不是在电路板上的表面安装或引线的过滤器罐。 该滤波器电路允许集成电路电子封装显着小于常规机电谐振器封装。 机械共振器可以在加工期间和使用期间由诸如钛的材料制成的保护盖保护。 保护盖连接到集成电路芯片。
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13.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US07235350B2
公开(公告)日：2007-06-26
申请号：US10969758
申请日：2004-10-20
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at a relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括厚度小于25微米，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳25密耳面积的面积上表现出低于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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公开(公告)号：US08024022B2
公开(公告)日：2011-09-20
申请号：US11380877
申请日：2006-04-28
IPC分类号： A61N1/05
CPC分类号： A61N1/0526 , A61N1/0531
摘要： The electrode array is a device for making electrical contacts with cellular tissue or organs. The electrode array includes an assembly of electrically conductive electrodes arising from a substrate where the electrodes are hermetically bonded to the substrate. The electrodes also include an insulating layer which leaves at least one zone or at least one hole exposed for making focused electrical contact with the tissue. A hole passing completely or partially through the electrode may further provide an anchor to the living tissue, thereby stabilizing the array with respect to the tissue being examined. Also, a method of manufacture of an electrode array and associated circuitry is disclosed.
摘要翻译： 电极阵列是用于与细胞组织或器官进行电接触的装置。 电极阵列包括由电极产生的导电电极的组件，其中电极气密地结合到衬底上。 电极还包括绝缘层，其离开暴露以用于与组织聚焦的电接触的至少一个区域或至少一个孔。 完全或部分穿过电极的孔可以进一步向活组织提供锚定，从而使阵列相对于被检查的组织稳定。 此外，公开了一种制造电极阵列和相关电路的方法。
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公开(公告)号：US07555328B2
公开(公告)日：2009-06-30
申请号：US11392163
申请日：2006-03-29
IPC分类号： A61B5/145
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensor may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译： 可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。 保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。 电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。 其上形成有电子电路和电极的基板是与其上形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。 这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。 在一个实施例中，两个这样的衬底传感器可以背靠背放置，电极面向外。 根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。
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16.发明授权Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权基于植入式酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US06934572B2
公开(公告)日：2005-08-23
申请号：US10286174
申请日：2002-10-31
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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17.发明授权Alumina insulation for coating implantable components and other microminiature devices 有权用于涂层可植入组件和其他微型设备的氧化铝绝缘公开(公告)号：US06844023B2
公开(公告)日：2005-01-18
申请号：US10251633
申请日：2002-09-20
IPC分类号： A61L2/00 , A61N1/02 , B05D3/00 , B32B9/00 , C23C14/00 , C23C14/04 , G03F1/00 , G03F7/20 , H01L21/308 , H01L23/29 , H05K3/28
CPC分类号： G03F7/70641 , A61N1/02 , A61N1/375 , C23C14/042 , H01L21/308 , H01L23/291 , H01L2924/0002 , H05K3/284 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265 , H01L2924/00
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80° C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括厚度小于25微米，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳×25密耳面积的面积上表现出小于10pA的漏电流，同时在高达80℃的温度下浸入盐水溶液中 一个三个月的时间。
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18.发明授权Electrode array for use in connection with a living body and method of manufacture 失效用于与活体相关的电极阵列和制造方法
公开(公告)号：US4969468A
公开(公告)日：1990-11-13
申请号：US300859
申请日：1989-01-24
CPC分类号： A61B5/6852 , A61B5/0422 , A61B5/685 , A61N1/05 , Y10T29/49124
摘要： The electrode array is a device for making multiple electrical contacts with cellular tissue or organs. The electrode array includes a base (1), a two dimensional array of conducting protuberances (2) arising from the base and serving as electrodes, and conductors (3) embedded onto the base and connected to such protuberances for transmitting electrical signals to and/or from the protuberances. The protuberances may also include an insulating layer (15) which covers either the entire protuberance or which leaves the tips exposed for making focused electrical contact. Electrode arrays may be used used singly or in combination with a second electrode array so as to form a sandwich around a target tissue. The sandwich electrode array (16, 17) may employ indexing cones for aligning the opposing electrode arrays and for limiting their vertical proximity. The conductors of the electrode array may be electronically connected or coupled to processing circuitry which amplifies and analyzes the signal received from the tissue and/or which generates signals which are sent to the target tissue and possibly coordinates the generated signals with signals which originate with the tissue.
摘要翻译： 电极阵列是用于与细胞组织或器官进行多次电接触的装置。 电极阵列包括基座（1），由基座产生并用作电极的导电突起（2）的二维阵列，以及嵌入到基座上并连接到这种突起上的导体（3），用于将电信号传输到和/ 或从突起。 突起还可以包括绝缘层（15），该绝缘层覆盖整个突起，或者留下暴露的尖端用于聚焦的电接触。 电极阵列可以单独使用或与第二电极阵列组合使用，以便在靶组织周围形成三明治。 夹心电极阵列（16,17）可以使用用于对准电极阵列的分度锥并限制它们的垂直接近。 电极阵列的导体可以电连接或耦合到处理电路，放大和分析从组织接收的信号和/或产生发送到目标组织的信号，并且可能用所产生的信号来协调产生的信号 组织。
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公开(公告)号：US08632607B2
公开(公告)日：2014-01-21
申请号：US13110269
申请日：2011-05-18
IPC分类号： A61F2/78
CPC分类号： A61F2/78 , A61F2002/546 , A61F2210/009
摘要： Permanent magnets or electromagnets or a combination of such magnets are provided to retain a prosthetic device on an extremity or limb, such as an amputated arm. The prosthesis utilizes the opposing forces, which are developed by virtue of like magnetic poles being in proximity to each other, to urge the prosthesis to remain attached to the extremity. The prosthesis is prevented from rotation by virtue of a centering force that is provided by an attachment magnet in the prosthesis being placed between two implanted magnets. A removable mounting ring is placed over the prosthesis to maintain it on the extremity.
摘要翻译： 提供永磁体或电磁体或这种磁体的组合以将修复装置保持在肢体或肢体，例如截肢的臂上。 假体利用由彼此靠近的相似磁极而开发的相对的力，以促使假体保持附接到肢体。 通过由放置在两个植入的磁体之间的假体中的附接磁体提供的定心力来防止假体旋转。 可拆卸的安装环放置在假体上以将其保持在肢体上。
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20.发明授权Alumina insulation for coating implantable components and other microminiature devices 失效用于涂层可植入组件和其他微型设备的氧化铝绝缘
公开(公告)号：US6043437A
公开(公告)日：2000-03-28
申请号：US994515
申请日：1997-12-19
IPC分类号： A61L2/00 , A61N1/02 , B05D3/00 , B32B9/00 , C23C14/00 , C23C14/04 , G03F1/00 , G03F7/20 , H01L21/308 , H01L23/29 , H05K3/28 , H05K1/03
CPC分类号： G03F7/70641 , C23C14/042 , H01L21/308 , H01L23/291 , H05K3/284 , A61N1/02 , A61N1/375 , H01L2924/0002 , Y10T29/49144 , Y10T428/24802 , Y10T428/24917 , Y10T428/24926 , Y10T428/265
摘要： A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material includes a thin layer or layers of alumina, zirconia, or other ceramic, less than 25 microns thick, e.g., 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils while soaking in a saline solution at temperatures up to 80.degree. C. over a three month period.
摘要翻译： 保护性的，生物相容的涂层或包封材料保护和绝缘想要植入生物体组织的组件或装置。 涂层或包封材料包括小于25微米厚，例如5-10微米厚的氧化铝，氧化锆或其它陶瓷的薄层或多层。 氧化铝层可以在相对较低的温度下施加。 一旦施加，该层提供优异的气密性，并防止漏电。 即使非常薄，氧化铝层保持优异的绝缘特性。 在一个实施方案中，小于约6微米厚的氧化铝层提供了一种绝缘涂层，其在75密耳×25密耳的区域上表现出低于10pA的漏电流，同时在温度高达80℃的盐水溶液中浸泡 三个月的时间。
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