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11.发明授权公开(公告)号：US08323900B2
公开(公告)日：2012-12-04
申请号：US13035725
申请日：2011-02-25
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , C12Q1/686 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2035/00881
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
摘要翻译： 本技术提供了用于检测样品中特别是生物样品中多核苷酸的装置。 该技术更特别涉及在微流体通道内对感兴趣的核苷酸进行PCR并检测这些核苷酸的微流体系统。 该装置包括被配置为接受多个样品并且可以分别对每个样品或一组或多个样品同时进行PCR的微流控盒。
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12.发明授权Integrated system for processing microfluidic samples, and method of using the same 有权用于加工微流体样品的集成系统及其使用方法公开(公告)号：US09040288B2
公开(公告)日：2015-05-26
申请号：US11728964
申请日：2007-03-26
申请人： Kalyan Handique , Sundaresh N. Brahmasandra , Karthik Ganesan , Betty Wu , Nikhil Phadke , Gene Parunak , Jeff Williams
发明人： Kalyan Handique , Sundaresh N. Brahmasandra , Karthik Ganesan , Betty Wu , Nikhil Phadke , Gene Parunak , Jeff Williams
CPC分类号： B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/06 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N2035/00881
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.
摘要翻译： 该专利申请描述了用于处理含有多核苷酸的样品并用于在其上提供诊断结果的集成设备。 该装置被配置为接收包含用于处理样品的试剂和网络的微流控盒。 还描述了使用该装置的方法。
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13.发明授权公开(公告)号：US07998708B2
公开(公告)日：2011-08-16
申请号：US11985577
申请日：2007-11-14
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , C12Q1/686 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2035/00881
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
摘要翻译： 本技术提供了用于检测样品中特别是生物样品中多核苷酸的装置。 该技术更特别涉及在微流体通道内对感兴趣的核苷酸进行PCR并检测这些核苷酸的微流体系统。 该装置包括被配置为接受多个样品并且可以分别对每个样品或一组或多个样品同时进行PCR的微流控盒。
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公开(公告)号：USD566291S1
公开(公告)日：2008-04-08
申请号：US29257030
申请日：2006-03-27
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公开(公告)号：US09186677B2
公开(公告)日：2015-11-17
申请号：US12218498
申请日：2008-07-14
申请人： Jeff Williams , Kerry Wilson , Kalyan Handique
发明人： Jeff Williams , Kerry Wilson , Kalyan Handique
CPC分类号： B01L3/502761 , B01L3/0275 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/06 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0425 , G01N2035/0436
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
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16.发明申请INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES 有权用于在多种生物样品上进行核酸提取和诊断测试的综合设备公开(公告)号：US20120171759A1
公开(公告)日：2012-07-05
申请号：US13417108
申请日：2012-03-09
申请人： Jeff Williams , Kalyan Handique , Kerry Wilson
发明人： Jeff Williams , Kalyan Handique , Kerry Wilson
CPC分类号： B01L7/52 , B01L3/5027 , B01L3/5085 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0436 , G01N2035/103
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
摘要翻译： 本文描述的技术通常涉及用于从多个样品，特别是来自生物样品中提取多核苷酸的系统，另外还涉及随后扩增和检测提取的多核苷酸的系统。 该技术更特别涉及在微流体通道内的多个目的核苷酸样品上进行PCR并检测这些核苷酸的微流体系统。
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公开(公告)号：US08182763B2
公开(公告)日：2012-05-22
申请号：US12178584
申请日：2008-07-23
申请人： Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
发明人： Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
IPC分类号： B01L9/06
CPC分类号： C12N15/1003 , B01L3/5082 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/16 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/0099 , G01N35/026 , G01N35/1002 , G01N2035/00772 , G01N2035/00801 , G01N2035/00881 , G01N2035/0493
摘要： A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.
摘要翻译： 用于容纳样品和各种试剂的支架，其中，在使用试剂之前，可以使用支架装载样品和试剂。 机架接受互补的试剂保持器，每个试剂容器包含用于进行预定处理操作的一组试剂，例如制备用于扩增和检测从样品提取的多核苷酸的生物样品。
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公开(公告)号：US09259734B2
公开(公告)日：2016-02-16
申请号：US13417108
申请日：2012-03-09
申请人： Jeff Williams , Kalyan Handique , Kerry Wilson
发明人： Jeff Williams , Kalyan Handique , Kerry Wilson
IPC分类号： B01L7/00 , B01L3/00 , B01L9/00 , F16K99/00 , B01L9/06 , G01N35/02 , G01N35/04 , G01N35/00 , G01N35/10
CPC分类号： B01L7/52 , B01L3/5027 , B01L3/5085 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0436 , G01N2035/103
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
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19.发明申请Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples 有权用于对多个生物样品进行核酸提取和诊断测试的综合装置公开(公告)号：US20090221059A1
公开(公告)日：2009-09-03
申请号：US12218498
申请日：2008-07-14
申请人： Jeff Williams , Kerry Wilson , Kalyan Handique
发明人： Jeff Williams , Kerry Wilson , Kalyan Handique
CPC分类号： B01L3/502761 , B01L3/0275 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/06 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0425 , G01N2035/0436
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
摘要翻译： 本文描述的技术通常涉及用于从多个样品，特别是来自生物样品中提取多核苷酸的系统，另外还涉及随后扩增和检测提取的多核苷酸的系统。 该技术更特别涉及在微流体通道内的多个目的核苷酸样品上进行PCR并检测这些核苷酸的微流体系统。
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公开(公告)号：US20120258463A1
公开(公告)日：2012-10-11
申请号：US13474980
申请日：2012-05-18
申请人： Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
发明人： Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
CPC分类号： C12N15/1003 , B01L3/5082 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/16 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/0099 , G01N35/026 , G01N35/1002 , G01N2035/00772 , G01N2035/00801 , G01N2035/00881 , G01N2035/0493 , Y10T436/113332
摘要： A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.
摘要翻译： 用于容纳样品和各种试剂的支架，其中，在使用试剂之前，可以使用支架装载样品和试剂。 机架接受互补的试剂保持器，每个试剂容器包含用于进行预定处理操作的一组试剂，例如制备用于扩增和检测从样品提取的多核苷酸的生物样品。
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